• Gene id: 9578

Gene Summary

• Gene Symbol: CDC42BPB   Gene   UCSC   Ensembl
• Aliases: MRCKB
• Gene name: CDC42 binding protein kinase beta
• Alternate names: serine/threonine-protein kinase MRCK beta, CDC42 binding protein kinase beta (DMPK-like), CDC42BP-beta, DMPK-like beta, MRCK beta, myotonic dystrophy kinase-related CDC42-binding kinase beta, myotonic dystrophy protein kinase-like beta,
• Gene location: 14q32.32 (103057548: 102932379)     Exons: 39     NC_000014.9
• Gene summary(Entrez): This gene encodes a member of the serine/threonine protein kinase family. The encoded protein contains a Cdc42/Rac-binding p21 binding domain resembling that of PAK kinase. The kinase domain of this protein is most closely related to that of myotonic dyst
• OMIM: 602673

Protein Summary

• Protein general information: Q9Y5S2  
  • Name: Serine/threonine protein kinase MRCK beta (EC 2.7.11.1) (CDC42 binding protein kinase beta) (CDC42BP beta) (DMPK like beta) (Myotonic dystrophy kinase related CDC42 binding kinase beta) (MRCK beta) (Myotonic dystrophy protein kinase like beta)
  • Length: 1711  
  • Mass: 194315
  • Tissue specificity: Expressed in all tissues examined, with high levels in heart, brain, placenta and lung. {ECO
• Sequence:

  MSAKVRLKKLEQLLLDGPWRNESALSVETLLDVLVCLYTECSHSALRRDKYVAEFLEWAKPFTQLVKEMQLHRED
  FEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQWITALHYAFQDENHLY
  LVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKM
  NDDGTVQSSVAVGTPDYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERF
  QFPSHVTDVSEEAKDLIQRLICSRERRLGQNGIEDFKKHAFFEGLNWENIRNLEAPYIPDVSSPSDTSNFDVDDD
  VLRNTEILPPGSHTGFSGLHLPFIGFTFTTESCFSDRGSLKSIMQSNTLTKDEDVQRDLEHSLQMEAYERRIRRL
  EQEKLELSRKLQESTQTVQSLHGSSRALSNSNRDKEIKKLNEEIERLKNKIADSNRLERQLEDTVALRQEREDST
  QRLRGLEKQHRVVRQEKEELHKQLVEASERLKSQAKELKDAHQQRKLALQEFSELNERMAELRAQKQKVSRQLRD
  KEEEMEVATQKVDAMRQEMRRAEKLRKELEAQLDDAVAEASKERKLREHSENFCKQMESELEALKVKQGGRGAGA
  TLEHQQEISKIKSELEKKVLFYEEELVRREASHVLEVKNVKKEVHDSESHQLALQKEILMLKDKLEKSKRERHNE
  MEEAVGTIKDKYERERAMLFDENKKLTAENEKLCSFVDKLTAQNRQLEDELQDLAAKKESVAHWEAQIAEIIQWV
  SDEKDARGYLQALASKMTEELEALRSSSLGSRTLDPLWKVRRSQKLDMSARLELQSALEAEIRAKQLVQEELRKV
  KDANLTLESKLKDSEAKNRELLEEMEILKKKMEEKFRADTGLKLPDFQDSIFEYFNTAPLAHDLTFRTSSASEQE
  TQAPKPEASPSMSVAASEQQEDMARPPQRPSAVPLPTTQALALAGPKPKAHQFSIKSFSSPTQCSHCTSLMVGLI
  RQGYACEVCSFACHVSCKDGAPQVCPIPPEQSKRPLGVDVQRGIGTAYKGHVKVPKPTGVKKGWQRAYAVVCDCK
  LFLYDLPEGKSTQPGVIASQVLDLRDDEFSVSSVLASDVIHATRRDIPCIFRVTASLLGAPSKTSSLLILTENEN
  EKRKWVGILEGLQSILHKNRLRNQVVHVPLEAYDSSLPLIKAILTAAIVDADRIAVGLEEGLYVIEVTRDVIVRA
  ADCKKVHQIELAPREKIVILLCGRNHHVHLYPWSSLDGAEGSFDIKLPETKGCQLMATATLKRNSGTCLFVAVKR
  LILCYEIQRTKPFHRKFNEIVAPGSVQCLAVLRDRLCVGYPSGFCLLSIQGDGQPLNLVNPNDPSLAFLSQQSFD
  ALCAVELESEEYLLCFSHMGLYVDPQGRRARAQELMWPAAPVACSCSPTHVTVYSEYGVDVFDVRTMEWVQTIGL
  RRIRPLNSEGTLNLLNCEPPRLIYFKSKFSGAVLNVPDTSDNSKKQMLRTRSKRRFVFKVPEEERLQQRREMLRD
  PELRSKMISNPTNFNHVAHMGPGDGMQVLMDLPLSAVPPSQEERPGPAPTNLARQPPSRNKPYISWPSSGGSEPS
  VTVPLRSMSDPDQDFDKEPDSDSTKHSTPSNSSNPSGPPSPNSPHRSQLPLEGLEQPACDT

• Structural information:
  • Protein Domains: (76..34-)
    (/note="Protein-kinase)
    (/evidence="ECO:0000250|UniProtKB:Q5VT25,-ECO:0000255|PROSITE-ProRule:PRU00159)
    (343..41-)
    (/note="AGC-kinase-C-terminal)
    (1095..121-)
    (/note="PH-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00145-)
    (-)
  • Interpro: IPR000961  IPR001180  IPR000095  IPR020454  IPR031597   IPR011009  IPR033232  IPR042718  IPR014930  IPR002219  IPR011993  IPR001849  IPR000719  IPR017441  IPR008271  
  • Prosite: PS51285 PS50219 PS50108 PS50003 PS00107 PS50011 PS00108 PS00479 PS50081
  • CDD: cd00029 cd05624
  • PDB: 3QFV 3TKU 4UAK 4UAL 5OTE 5OTF
  • PDBsum: 3QFV 3TKU 4UAK 4UAL 5OTE 5OTF
  • STRING: ENSP00000355237
• Other Databases: GeneCards:  CDC42BPB  Malacards:  CDC42BPB

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0042641	actomyosin	IBA	cellular component
GO:0031032	actomyosin structure organization	IBA	biological process
GO:0018107	peptidyl-threonine phosphorylation	IBA	biological process
GO:0005856	cytoskeleton	IBA	cellular component
GO:0005737	cytoplasm	IBA	cellular component
GO:0004674	protein serine/threonine kinase activity	IBA	molecular function
GO:0042641	actomyosin	IDA	cellular component
GO:0006468	protein phosphorylation	IDA	biological process
GO:0004672	protein kinase activity	IDA	molecular function
GO:0031032	actomyosin structure organization	IMP	biological process
GO:0016477	cell migration	IMP	biological process
GO:0030027	lamellipodium	ISS	cellular component
GO:0016477	cell migration	IEA	biological process
GO:0030036	actin cytoskeleton organization	IEA	biological process
GO:0004672	protein kinase activity	IEA	molecular function
GO:0004674	protein serine/threonine kinase activity	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0006468	protein phosphorylation	IEA	biological process
GO:0035556	intracellular signal transduction	IEA	biological process
GO:0016740	transferase activity	IEA	molecular function
GO:0030054	cell junction	IEA	cellular component
GO:0046872	metal ion binding	IEA	molecular function
GO:0042995	cell projection	IEA	cellular component
GO:0016301	kinase activity	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005524	ATP binding	IEA	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0016310	phosphorylation	IEA	biological process
GO:0005886	plasma membrane	IEA	cellular component
GO:0000166	nucleotide binding	IEA	molecular function
GO:0004674	protein serine/threonine kinase activity	IEA	molecular function
GO:0004672	protein kinase activity	TAS	molecular function
GO:0005856	cytoskeleton	TAS	cellular component
GO:0007163	establishment or maintenance of cell polarity	TAS	biological process
GO:0007165	signal transduction	TAS	biological process
GO:0007010	cytoskeleton organization	TAS	biological process
GO:0006468	protein phosphorylation	IEA	biological process
GO:0004674	protein serine/threonine kinase activity	IEA	molecular function
GO:0042641	actomyosin	IEA	cellular component
GO:0031032	actomyosin structure organization	IEA	biological process
GO:0030036	actin cytoskeleton organization	IEA	biological process
GO:0017048	Rho GTPase binding	IEA	molecular function
GO:0016477	cell migration	IEA	biological process
GO:0030054	cell junction	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0030027	lamellipodium	IEA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component
GO:0000287	magnesium ion binding	ISS	molecular function
GO:0031532	actin cytoskeleton reorganization	ISS	biological process
GO:0031252	cell leading edge	ISS	cellular component
GO:0006468	protein phosphorylation	ISS	biological process
GO:0005524	ATP binding	ISS	molecular function
GO:0004674	protein serine/threonine kinase activity	ISS	molecular function
GO:0005911	cell-cell junction	ISS	cellular component
GO:0044877	protein-containing complex binding	IPI	molecular function

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200
Spermatogenic defects	MIK: 31037746
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
31037746	Spermatogenic defects			28 men with azoospermia	Male infertility	Microarray
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray