|
Gene id |
9576 |
| Gene Summary Protein Summary Gene ontology Diseases PubMed |
Gene Summary
|
|
Gene Symbol |
SPAG6 Gene UCSC Ensembl |
|
Aliases |
CT141, Repro-SA-1, pf16 |
|
Gene name |
sperm associated antigen 6 |
|
Alternate names |
sperm-associated antigen 6, axoneme central apparatus protein, protein PF16 homolog, sperm flagellar protein, testicular tissue protein Li 176, |
|
Gene location |
10p12.2 (22345444: 22417609) Exons: 15 NC_000073.6
|
|
Gene summary(Entrez) |
The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targete
|
|
OMIM |
605730 |
Protein Summary
|
|
| GO accession | Term name | Evidence code | Go category |
|---|
|
|
| Associated diseases |
References |
| Alzheimer's disease | GAD: 16385451 |
| Asthenozoospermia | MIK: 29726644 |
| Asthenoteratospermia | MIK: 32124190 |
| Cryptorchidism | MIK: 28606200 |
| Athenozoospermia | MIK: 29726644 |
| Male infertility | MIK: 29726644 |
| Spermatogenic defects | MIK: 31037746 |
| Teratozoospermia | MIK: 17327269 |
|
|
| PMID |
Condition |
Mutation |
Ethnicity |
Population details |
Infertility_type |
Associated_genes |
Abstract |
| 29726644 |
Idiopathic
asthenozo
ospermia,
Male infer
tility
|
|
|
100 (50 idiopat
hic asthenozoos
permia patients
, 50 normal spe
rm donors)
|
Male infertility |
|
Show abstract |
| 32124190 |
Asthenoter
atospermia
|
c.143_145del: p.48_49del, c.585delA: p.Lys196Serfs*6 |
|
215 oligo-asthe
nospermia (OAT)
patients
|
Male infertility |
|
Show abstract |
| 17327269 |
Teratozoos
permia
|
|
|
19 (6 controls
, 13 cases)
|
Male infertility |
GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
|
Show abstract |
| 28606200 |
Cryptorchi
dism
|
|
|
Monozgotic twin
s (1 control, I
cwith cryptorc
hidism)
|
Male infertility |
MeDIP-Seq
|
Show abstract |
| 31037746 |
Spermatoge
nic defect
s
|
|
|
28 men with az
oospermia
|
Male infertility |
Microarray
|
Show abstract |
| 31037746 |
Spermatoge
nic defect
s
|
|
|
16 (1 control,
15 cases)
|
Male infertility |
GSE6023 analyzed using GEO2R
|
Show abstract |
|