• Gene id: 9543

Gene Summary

• Gene Symbol: IGDCC3   Gene   UCSC   Ensembl
• Aliases: HsT18880, PUNC
• Gene name: immunoglobulin superfamily DCC subclass member 3
• Alternate names: immunoglobulin superfamily DCC subclass member 3, putative neuronal cell adhesion molecule,
• Gene location: 15q22.31 (65378001: 65327126)     Exons: 16     NC_000015.10
• OMIM: 604184

Protein Summary

• Protein general information: Q8IVU1  
  • Name: Immunoglobulin superfamily DCC subclass member 3 (Putative neuronal cell adhesion molecule)
  • Length: 814  
  • Mass: 86724
• Sequence:

  MAVQRAASPRRPPAPLWPRLLLPLLLLLLPAPSEGLGHSAELAFAVEPSDDVAVPGQPIVLDCRVEGTPPVRITW
  RKNGVELPESTHSTLLANGSLMIRHFRLEPGGSPSDEGDYECVAQNRFGLVVSRKARIQAATMSDFHVHPQATVG
  EEGGVARFQCQIHGLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRISHGARL
  TVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGVEGIQVLGTGNLIISDVTVQ
  HSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGH
  VRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTVLWAEGLPGPPRNVRAVSVSSTEVRVSWSEPLAN
  TKEIIGYVLHIRKAADPPELEYQEAVSKSTFQHLVSDLEPSTAYSFYIKAYTPRGASSASVPTLASTLGEAPAPP
  PLSVRVLGSSSLQLLWEPWPRLAQHEGGFKLFYRPASKTSFTGPILLPGTVSSYNLSQLDPTAVYEVKLLAYNQH
  GDGNATVRFVSLRGASERTALSPPCDCRKEEAANQTSTTGIVIGIHIGVTCIIFCVLFLLFGQRGRVLLCKDVEN
  QLSPPQGPRSQRDPGILALNGARRGQRGQLGRDEKRVDMKELEQLFPPASAAGQPDPRPTQDPAAPAPCEETQLS
  VLPLQGCGLMEGKTTEAKTTEATAPCAGLAAAPPPPDGGPGLLSEGQASRPAAARVTQPAHSEQ

• Structural information:
  • Protein Domains: (36..13-)
    1 (/note="Ig-like-C2-type)
    (140..22-)
    2 (/note="Ig-like-C2-type)
    (238..32-)
    3 (/note="Ig-like-C2-type)
    (329..41-)
    4 (/note="Ig-like-C2-type)
    (426..52-)
    1 (/note="Fibronectin-type-III)
    (/evidence="ECO:0000255|PR-)
  • Interpro: IPR003961  IPR036116  IPR007110  IPR036179  IPR013783   IPR013098  IPR003599  IPR003598  
  • Prosite: PS50853 PS50835
  • CDD: cd00063
  • STRING: ENSP00000332773
• Other Databases: GeneCards:  IGDCC3  Malacards:  IGDCC3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0016021	integral component of membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0050885	neuromuscular process controlling balance	IEA	biological process
GO:0005887	integral component of plasma membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq