• Gene id: 9536

Gene Summary

• Gene Symbol: PTGES   Gene   UCSC   Ensembl
• Aliases: MGST-IV, MGST1-L1, MGST1L1, MPGES, PGES, PIG12, PP102, PP1294, TP53I12, mPGES-1
• Gene name: prostaglandin E synthase
• Alternate names: prostaglandin E synthase, MGST1-like 1, glutathione S-transferase 1-like 1, microsomal glutathione S-transferase 1-like 1, microsomal prostaglandin E synthase-1, p53-induced apoptosis protein 12, p53-induced gene 12 protein, tumor protein p53 inducible protein 1,
• Gene location: 9q34.11 (129753041: 129738348)     Exons: 3     NC_000009.12
• Gene summary(Entrez): The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor pr
• OMIM: 605172

Protein Summary

• Protein general information: O14684  
  • Name: Prostaglandin E synthase (EC 5.3.99.3) (Microsomal glutathione S transferase 1 like 1) (MGST1 L1) (Microsomal prostaglandin E synthase 1) (MPGES 1) (p53 induced gene 12 protein)
  • Length: 152  
  • Mass: 17102
• Sequence:

  MPAHSLVMSSPALPAFLLCSTLLVIKMYVVAIITGQVRLRKKAFANPEDALRHGGPQYCRSDPDVERCLRAHRND
  METIYPFLFLGFVYSFLGPNPFVAWMHFLVFLVGRVAHTVAYLGKLRAPIRSVTYTLAQLPCASMALQILWEAAR
  HL

• Structural information:
  • Interpro: IPR023352  IPR001129  IPR040162  
  • PDB: 3DWW 4AL0 4AL1 4BPM 4WAB 4YK5 4YL0 4YL1 4YL3 5BQG 5BQH 5BQI 5K0I 5T36 5T37 5TL9
  • PDBsum: 3DWW 4AL0 4AL1 4BPM 4WAB 4YK5 4YL0 4YL1 4YL3 5BQG 5BQH 5BQI 5K0I 5T36 5T37 5TL9
  • STRING: ENSP00000342385
• Other Databases: GeneCards:  PTGES  Malacards:  PTGES

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0055114	oxidation-reduction process	IBA	biological process
GO:0050220	prostaglandin-E synthase activity	IBA	molecular function
GO:0016021	integral component of membrane	IBA	cellular component
GO:0001516	prostaglandin biosynthetic process	IBA	biological process
GO:0050220	prostaglandin-E synthase activity	IDA	molecular function
GO:0043295	glutathione binding	IDA	molecular function
GO:0016021	integral component of membrane	IDA	cellular component
GO:0001516	prostaglandin biosynthetic process	IDA	biological process
GO:0006693	prostaglandin metabolic process	IEA	biological process
GO:0006633	fatty acid biosynthetic process	IEA	biological process
GO:0016853	isomerase activity	IEA	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0006629	lipid metabolic process	IEA	biological process
GO:0006631	fatty acid metabolic process	IEA	biological process
GO:0016021	integral component of membrane	IEA	cellular component
GO:0001516	prostaglandin biosynthetic process	IEA	biological process
GO:0006693	prostaglandin metabolic process	TAS	biological process
GO:0007165	signal transduction	NAS	biological process
GO:0016020	membrane	TAS	cellular component
GO:0050220	prostaglandin-E synthase activity	IEA	molecular function
GO:0005789	endoplasmic reticulum membrane	TAS	cellular component
GO:0019371	cyclooxygenase pathway	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0004667	prostaglandin-D synthase activity	IEA	molecular function
GO:0006693	prostaglandin metabolic process	IEA	biological process
GO:0008285	negative regulation of cell population proliferation	IEA	biological process
GO:0002544	chronic inflammatory response	IEA	biological process
GO:0014070	response to organic cyclic compound	IEA	biological process
GO:0034097	response to cytokine	IEA	biological process
GO:0043231	intracellular membrane-bounded organelle	IEA	cellular component
GO:0048471	perinuclear region of cytoplasm	IEA	cellular component
GO:0050220	prostaglandin-E synthase activity	IEA	molecular function
GO:0051592	response to calcium ion	IEA	biological process
GO:0001516	prostaglandin biosynthetic process	IEA	biological process
GO:0005641	nuclear envelope lumen	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0001516	prostaglandin biosynthetic process	IEA	biological process
GO:0002526	acute inflammatory response	IEA	biological process
GO:0032496	response to lipopolysaccharide	IEA	biological process
GO:0032526	response to retinoic acid	IEA	biological process
GO:0016020	membrane	IEA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa00590	Arachidonic acid metabolism

Diseases

Associated diseases	References
Ductal carcinoma in situ	PMID:16353170
penile neoplasm	PMID:14871981
ovary epithelial cancer	PMID:17107625
Transitional cell carcinoma	PMID:14499677
Endometrial adenocarcinoma	PMID:11592775
Endometriosis	PMID:17295901
lung non-small cell carcinoma	PMID:20592629
in situ carcinoma	PMID:14871981
in situ carcinoma	PMID:14499677
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881