• Gene id: 9470

Gene Summary

• Gene Symbol: EIF4E2   Gene   UCSC   Ensembl
• Aliases: 4E-LP, 4EHP, EIF4EL3, IF4e, h4EHP
• Gene name: eukaryotic translation initiation factor 4E family member 2
• Alternate names: eukaryotic translation initiation factor 4E type 2, eIF-4E type 2, eIF4E-like cap-binding protein, eIF4E-like protein 4E-LP, eukaryotic translation initiation factor 4E homologous protein, eukaryotic translation initiation factor 4E-like 3, mRNA cap-binding pro,
• Gene location: 2q37.1 (232550586: 232583644)     Exons: 15     NC_000002.12
• OMIM: 605895

Protein Summary

• Protein general information: O60573  
  • Name: Eukaryotic translation initiation factor 4E type 2 (eIF 4E type 2) (eIF4E type 2) (Eukaryotic translation initiation factor 4E homologous protein) (Eukaryotic translation initiation factor 4E like 3) (eIF4E like protein 4E LP) (mRNA cap binding protein 4E
  • Length: 245  
  • Mass: 28362
• Sequence:

  MNNKFDALKDDDSGDHDQNEENSTQKDGEKEKTERDKNQSSSKRKAVVPGPAEHPLQYNYTFWYSRRTPGRPTSS
  QSYEQNIKQIGTFASVEQFWRFYSHMVRPGDLTGHSDFHLFKEGIKPMWEDDANKNGGKWIIRLRKGLASRCWEN
  LILAMLGEQFMVGEEICGAVVSVRFQEDIISIWNKTASDQATTARIRDTLRRVLNLPPNTIMEYKTHTDSIKMPG
  RLGPQRLLFQNLWKPRLNVP

• Structural information:
  • Interpro: IPR023398  IPR001040  IPR019770  
  • Prosite: PS00813
  • PDB: 2JGB 2JGC 5NVK 5NVL 5NVM 5NVN 5XLN
  • PDBsum: 2JGB 2JGC 5NVK 5NVL 5NVM 5NVN 5XLN
  • DIP: 32578
  • STRING: ENSP00000258416
• Other Databases: GeneCards:  EIF4E2  Malacards:  EIF4E2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0003743	translation initiation factor activity	IBA	molecular function
GO:0000340	RNA 7-methylguanosine cap binding	IBA	molecular function
GO:0016281	eukaryotic translation initiation factor 4F complex	IBA	cellular component
GO:0005845	mRNA cap binding complex	IDA	cellular component
GO:0031625	ubiquitin protein ligase binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0003743	translation initiation factor activity	IEA	molecular function
GO:0003723	RNA binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0006413	translational initiation	IEA	biological process
GO:0003743	translation initiation factor activity	IEA	molecular function
GO:0006412	translation	IEA	biological process
GO:0006417	regulation of translation	IEA	biological process
GO:0003723	RNA binding	IEA	molecular function
GO:0006413	translational initiation	IEA	biological process
GO:0008135	translation factor activity, RNA binding	TAS	molecular function
GO:0000339	RNA cap binding	TAS	molecular function
GO:0017148	negative regulation of translation	IMP	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0001701	in utero embryonic development	IEA	biological process
GO:0003723	RNA binding	HDA	molecular function

KEGG pathways

Pathway id	Pathway name
hsa04151	PI3K-Akt signaling pathway
hsa03013	RNA transport
hsa04150	mTOR signaling pathway
hsa04910	Insulin signaling pathway
hsa04066	HIF-1 signaling pathway
hsa04211	Longevity regulating pathway
hsa01521	EGFR tyrosine kinase inhibitor resistance

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)