Gene id |
9466 |
Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed |
Gene Summary
|
Gene Symbol |
IL27RA Gene UCSC Ensembl |
Aliases |
CRL1, IL-27RA, IL27R, TCCR, WSX1, zcytor1 |
Gene name |
interleukin 27 receptor subunit alpha |
Alternate names |
interleukin-27 receptor subunit alpha, IL-27 receptor subunit alpha, IL-27R subunit alpha, IL-27R-alpha, T-cell cytokine receptor type 1, class I cytokine receptor, cytokine receptor WSX-1, cytokine receptor-like 1, interleukin 27 receptor, alpha, type I T-cell cy, |
Gene location |
19p13.12 (14031761: 14053217) Exons: 14 NC_000019.10
|
Gene summary(Entrez) |
In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most a
|
OMIM |
607110 |
Protein Summary
|
Protein general information
| Q6UWB1
Name: Interleukin 27 receptor subunit alpha (IL 27 receptor subunit alpha) (IL 27R subunit alpha) (IL 27R alpha) (IL 27RA) (Cytokine receptor WSX 1) (Cytokine receptor like 1) (Type I T cell cytokine receptor) (TCCR) (ZcytoR1)
Length: 636 Mass: 69474
Tissue specificity: Highly expressed in lymphoid tissues such as spleen, lymph nodes and peripheral blood leukocytes. Weakly expressed in other tissues examined including heart, brain, fetal and adult lung, liver, skeletal muscle, kidney, pancreas, prosta
|
Sequence |
MRGGRGAPFWLWPLPKLALLPLLWVLFQRTRPQGSAGPLQCYGVGPLGDLNCSWEPLGDLGAPSELHLQSQKYRS NKTQTVAVAAGRSWVAIPREQLTMSDKLLVWGTKAGQPLWPPVFVNLETQMKPNAPRLGPDVDFSEDDPLEATVH WAPPTWPSHKVLICQFHYRRCQEAAWTLLEPELKTIPLTPVEIQDLELATGYKVYGRCRMEKEEDLWGEWSPILS FQTPPSAPKDVWVSGNLCGTPGGEEPLLLWKAPGPCVQVSYKVWFWVGGRELSPEGITCCCSLIPSGAEWARVSA VNATSWEPLTNLSLVCLDSASAPRSVAVSSIAGSTELLVTWQPGPGEPLEHVVDWARDGDPLEKLNWVRLPPGNL SALLPGNFTVGVPYRITVTAVSASGLASASSVWGFREELAPLVGPTLWRLQDAPPGTPAIAWGEVPRHQLRGHLT HYTLCAQSGTSPSVCMNVSGNTQSVTLPDLPWGPCELWVTASTIAGQGPPGPILRLHLPDNTLRWKVLPGILFLW GLFLLGCGLSLATSGRCYHLRHKVLPRWVWEKVPDPANSSSGQPHMEQVPEAQPLGDLPILEVEEMEPPPVMESS QPAQATAPLDSGYEKHFLPTPEELGLLGPPRPQVLA
|
Structural information | Protein Domains
|
(131..23-) 1 (/note="Fibronectin-type-III) (/evidence="ECO:0000255|PROSITE-ProRule:PRU00316-) (322..41-) 2 (/note="Fibronectin-type-III) (/evidence="ECO:0000255|PROSITE-ProRule:PRU00316-) (419..51-) 3 (/note="Fibronectin-type-III) (/e-)
|
Interpro: |
IPR003961 IPR036116 IPR013783 |
Prosite: |
PS50853 |
CDD: |
cd00063 |
STRING: |
ENSP00000263379 |
|
Other Databases |
GeneCards: IL27RA Malacards: IL27RA |
|
GO accession | Term name | Evidence code | Go category |
---|
GO:0019221 |
cytokine-mediated signali ng pathway
|
IBA |
biological process |
GO:0019955 |
cytokine binding
|
IBA |
molecular function |
GO:0043235 |
receptor complex
|
IBA |
cellular component |
GO:0004896 |
cytokine receptor activit y
|
IBA |
molecular function |
GO:0009897 |
external side of plasma m embrane
|
IBA |
cellular component |
GO:0042531 |
positive regulation of ty rosine phosphorylation of STAT protein
|
IBA |
biological process |
GO:0045509 |
interleukin-27 receptor a ctivity
|
IBA |
molecular function |
GO:0016021 |
integral component of mem brane
|
IEA |
cellular component |
GO:0016020 |
membrane
|
IEA |
cellular component |
GO:0004888 |
transmembrane signaling r eceptor activity
|
TAS |
molecular function |
GO:0005887 |
integral component of pla sma membrane
|
TAS |
cellular component |
GO:0006955 |
immune response
|
TAS |
biological process |
GO:0007166 |
cell surface receptor sig naling pathway
|
TAS |
biological process |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0070106 |
interleukin-27-mediated s ignaling pathway
|
TAS |
biological process |
GO:0070757 |
interleukin-35-mediated s ignaling pathway
|
TAS |
biological process |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:1900165 |
negative regulation of in terleukin-6 secretion
|
IEA |
biological process |
GO:0050830 |
defense response to Gram- positive bacterium
|
IEA |
biological process |
GO:0002829 |
negative regulation of ty pe 2 immune response
|
IEA |
biological process |
GO:0002827 |
positive regulation of T- helper 1 type immune resp onse
|
IEA |
biological process |
GO:2000408 |
negative regulation of T cell extravasation
|
IEA |
biological process |
GO:2000317 |
negative regulation of T- helper 17 type immune res ponse
|
IEA |
biological process |
GO:1905077 |
negative regulation of in terleukin-17 secretion
|
IEA |
biological process |
GO:1904468 |
negative regulation of tu mor necrosis factor secre tion
|
IEA |
biological process |
GO:0048302 |
regulation of isotype swi tching to IgG isotypes
|
IEA |
biological process |
GO:0045509 |
interleukin-27 receptor a ctivity
|
IEA |
molecular function |
GO:0032729 |
positive regulation of in terferon-gamma production
|
IEA |
biological process |
GO:0002692 |
negative regulation of ce llular extravasation
|
IEA |
biological process |
GO:0016020 |
membrane
|
IEA |
cellular component |
|
|
Pathway id | Pathway name |
hsa04060 | Cytokine-cytokine receptor interaction | hsa04630 | JAK-STAT signaling pathway | hsa04659 | Th17 cell differentiation | |
|
Associated diseases |
References |
systemic scleroderma | PMID:20705635 |
Cryptorchidism | MIK: 28606200 |
|
|
PMID |
Condition |
Mutation |
Ethnicity |
Population details |
Infertility_type |
Associated_genes |
Abstract |
28606200 |
Cryptorchi dism
|
|
|
Monozgotic twin s (1 control, I cwith cryptorc hidism)
|
Male infertility |
MeDIP-Seq
|
Show abstract |
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