• Gene id: 9453

Gene Summary

• Gene Symbol: GGPS1   Gene   UCSC   Ensembl
• Aliases: GGPPS, GGPPS1
• Gene name: geranylgeranyl diphosphate synthase 1
• Alternate names: geranylgeranyl pyrophosphate synthase, (2E,6E)-farnesyl diphosphate synthase, GGPP synthase, GGPPSase, dimethylallyltranstransferase, farnesyl diphosphate synthase, farnesyltranstransferase, geranyltranstransferase,
• Gene location: 1q42.3 (235328437: 235344531)     Exons: 5     NC_000009.12
• Gene summary(Entrez): This gene is a member of the prenyltransferase family and encodes a protein with geranylgeranyl diphosphate (GGPP) synthase activity. The enzyme catalyzes the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. GGPP is an important mo
• OMIM: 606982

Protein Summary

Gene ontology

GO accession	Term name	Evidence code	Go category

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa01100	Metabolic pathways
hsa00900	Terpenoid backbone biosynthesis

Diseases

Associated diseases	References
Sertoli cell only syndrome (SCOS)	MIK: 27374985
Male factor infertility	MIK: 27374985
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Sertoli-cell-only syndrome	MIK: 27374985
Male infertility	MIK: 27374985
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
27374985	Sertoli-cell-only syndrome, Male infertility				Male infertility
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
31037746	Spermatogenic defects			28 men with azoospermia	Male infertility	Microarray
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R