• Gene id: 9446

Gene Summary

• Gene Symbol: GSTO1   Gene   UCSC   Ensembl
• Aliases: GSTO 1-1, GSTTLp28, HEL-S-21, P28, SPG-R
• Gene name: glutathione S-transferase omega 1
• Alternate names: glutathione S-transferase omega-1, MMA(V) reductase, S-(Phenacyl)glutathione reductase, epididymis secretory protein Li 21, glutathione S-transferase omega 1-1, glutathione-S-transferase like, glutathione-dependent dehydroascorbate reductase, monomethylarsonic a,
• Gene location: 10q25.1 (104254193: 104267463)     Exons: 7     NC_000010.11
• Gene summary(Entrez): The protein encoded by this gene is an omega class glutathione S-transferase (GST) with glutathione-dependent thiol transferase and dehydroascorbate reductase activities. GSTs are involved in the metabolism of xenobiotics and carcinogens. The encoded prot
• OMIM: 605482

Protein Summary

• Protein general information: P78417  
  • Name: Glutathione S transferase omega 1 (GSTO 1) (EC 2.5.1.18) (Glutathione S transferase omega 1 1) (GSTO 1 1) (Glutathione dependent dehydroascorbate reductase) (EC 1.8.5.1) (Monomethylarsonic acid reductase) (MMA(V) reductase) (EC 1.20.4.2) (S (Phenacyl)glut
  • Length: 241  
  • Mass: 27566
  • Tissue specificity: Ubiquitous. Highest expression in liver, pancreas, skeletal muscle, spleen, thymus, colon, blood leukocyte and heart. Lowest expression in brain, placenta and lung. {ECO
• Sequence:

  MSGESARSLGKGSAPPGPVPEGSIRIYSMRFCPFAERTRLVLKAKGIRHEVININLKNKPEWFFKKNPFGLVPVL
  ENSQGQLIYESAITCEYLDEAYPGKKLLPDDPYEKACQKMILELFSKVPSLVGSFIRSQNKEDYAGLKEEFRKEF
  TKLEEVLTNKKTTFFGGNSISMIDYLIWPWFERLEAMKLNECVDHTPKLKLWMAAMKEDPTVSALLTSEKDWQGF
  LELYLQNSPEACDYGL

• Structural information:
  • Protein Domains: (22..10-)
    (/note="GST-N-terminal)
    (106..23-)
    (/note="GST-C-terminal")
  • Interpro: IPR010987  IPR036282  IPR004045  IPR004046  IPR005442   IPR036249  
  • Prosite: PS50405 PS50404
  • PDB: 1EEM 3LFL 3VLN 4IS0 4YQM 4YQU 4YQV 5UEH 5V3Q 5YVN 5YVO 6MHB 6MHC 6MHD 6PNM 6PNN 6PNO
  • PDBsum: 1EEM 3LFL 3VLN 4IS0 4YQM 4YQU 4YQV 5UEH 5V3Q 5YVN 5YVO 6MHB 6MHC 6MHD 6PNM 6PNN 6PNO
  • STRING: ENSP00000358727
• Other Databases: GeneCards:  GSTO1  Malacards:  GSTO1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0045174	glutathione dehydrogenase (ascorbate) activity	IBA	molecular function
GO:0055114	oxidation-reduction process	IBA	biological process
GO:0045174	glutathione dehydrogenase (ascorbate) activity	IDA	molecular function
GO:0019852	L-ascorbic acid metabolic process	IDA	biological process
GO:0071243	cellular response to arsenic-containing substance	IDA	biological process
GO:0042178	xenobiotic catabolic process	IDA	biological process
GO:0016491	oxidoreductase activity	IDA	molecular function
GO:0005737	cytoplasm	IDA	cellular component
GO:0004364	glutathione transferase activity	IDA	molecular function
GO:0004364	glutathione transferase activity	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0016740	transferase activity	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0016491	oxidoreductase activity	IEA	molecular function
GO:0045174	glutathione dehydrogenase (ascorbate) activity	IEA	molecular function
GO:0004364	glutathione transferase activity	IEA	molecular function
GO:0050610	methylarsonate reductase activity	IEA	molecular function
GO:0035722	interleukin-12-mediated signaling pathway	TAS	biological process
GO:1901687	glutathione derivative biosynthetic process	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0032259	methylation	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	IDA	biological process
GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	IC	biological process
GO:0014810	positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion	IC	biological process
GO:0060316	positive regulation of ryanodine-sensitive calcium-release channel activity	IDA	biological process
GO:0060315	negative regulation of ryanodine-sensitive calcium-release channel activity	IDA	biological process
GO:0005829	cytosol	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0098869	cellular oxidant detoxification	IEA	biological process
GO:0098869	cellular oxidant detoxification	IEA	biological process
GO:0098869	cellular oxidant detoxification	IEA	biological process
GO:0070062	extracellular exosome	HDA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa05200	Pathways in cancer
hsa05225	Hepatocellular carcinoma
hsa05418	Fluid shear stress and atherosclerosis
hsa00983	Drug metabolism - other enzymes
hsa05204	Chemical carcinogenesis
hsa00980	Metabolism of xenobiotics by cytochrome P450
hsa00982	Drug metabolism - cytochrome P450
hsa01524	Platinum drug resistance
hsa00480	Glutathione metabolism

Diseases

Associated diseases	References
Alzheimer's disease	PMID:14570706
Alzheimer's disease	PMID:20818931
Parkinson's disease	PMID:14570706
Teratozoospermia	MIK: 17327269
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray