• Gene id: 94033

Gene Summary

• Gene Symbol: FTMT   Gene   UCSC   Ensembl
• Aliases: MTF
• Gene name: ferritin mitochondrial
• Alternate names: ferritin, mitochondrial, ferritin H subunit, mitochondrial ferritin,
• Gene location: 5q23.1 (121851881: 121852832)     Exons: 8     NC_000005.10
• OMIM: 608847

Protein Summary

• Protein general information: Q8N4E7  
  • Name: Ferritin, mitochondrial (EC 1.16.3.1)
  • Length: 242  
  • Mass: 27538
  • Tissue specificity: Detected in testis and erythroleukemia. Expression is very low or not detectable in brain, colon, heart, kidney, liver, lung, muscle, placental, spleen and small intestine. {ECO
• Sequence:

  MLSCFRLLSRHISPSLASLRPVRCCFALPLRWAPGRPLDPRQIAPRRPLAAAASSRDPTGPAAGPSRVRQNFHPD
  SEAAINRQINLELYASYVYLSMAYYFSRDDVALNNFSRYFLHQSREETEHAEKLMRLQNQRGGRIRLQDIKKPEQ
  DDWESGLHAMECALLLEKNVNQSLLELHALASDKGDPHLCDFLETYYLNEQVKSIKELGDHVHNLVKMGAPDAGL
  AEYLFDTHTLGNENKQN

• Structural information:
  • Protein Domains: (70..21-)
    (/note="Ferritin-like-diiron)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00085"-)
  • Interpro: IPR001519  IPR012347  IPR009040  IPR009078  IPR014034   IPR008331  
  • Prosite: PS00204 PS50905
  • PDB: 1R03 5Z8J 5Z8S 5Z8U 5Z91
  • PDBsum: 1R03 5Z8J 5Z8S 5Z8U 5Z91
  • STRING: ENSP00000313691
• Other Databases: GeneCards:  FTMT  Malacards:  FTMT

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0008198	ferrous iron binding	IBA	molecular function
GO:0006880	intracellular sequestering of iron ion	IBA	biological process
GO:0005737	cytoplasm	IBA	cellular component
GO:0008199	ferric iron binding	IBA	molecular function
GO:0005506	iron ion binding	IBA	molecular function
GO:0004322	ferroxidase activity	IBA	molecular function
GO:0006826	iron ion transport	IEA	biological process
GO:0006879	cellular iron ion homeostasis	IEA	biological process
GO:0008199	ferric iron binding	IEA	molecular function
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0006879	cellular iron ion homeostasis	IEA	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0005739	mitochondrion	IEA	cellular component
GO:0016491	oxidoreductase activity	IEA	molecular function
GO:0004322	ferroxidase activity	IEA	molecular function
GO:0005759	mitochondrial matrix	TAS	cellular component
GO:0006879	cellular iron ion homeostasis	TAS	biological process
GO:1904234	positive regulation of aconitate hydratase activity	IGI	biological process
GO:1904231	positive regulation of succinate dehydrogenase activity	IGI	biological process
GO:0006879	cellular iron ion homeostasis	IDA	biological process
GO:0008284	positive regulation of cell population proliferation	IDA	biological process
GO:0051349	positive regulation of lyase activity	IDA	biological process
GO:0005739	mitochondrion	IEA	cellular component
GO:0005634	nucleus	HDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa04216	Ferroptosis

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200
Non obstructive azoospermia	MIK: 24012201
Sertoli cell only syndrome	MIK: 23869807

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
24012201	Non obstructive azoospermia			31 (4 controls, 27 cases)	Male infertility	GSE45885 analyzed by GEO2R (cutoff 1.5 fold)
23869807	Non obstructive azoospermia, Sertoli cell only syndrome			20 (4 controls, 16 cases)	Male infertility	GSE45887 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq