• Gene id: 93974

Gene Summary

• Gene Symbol: ATP5IF1   Gene   UCSC   Ensembl
• Aliases: ATPI, ATPIF1, ATPIP, IP
• Gene name: ATP synthase inhibitory factor subunit 1
• Alternate names: ATPase inhibitor, mitochondrial, ATP synthase F1 subunit epsilon, ATP synthase inhibitor protein, ATPase inhibitor protein, ATPase inhibitory factor 1, IF(1), IF1, inhibitor of F(1)F(o)-ATPase,
• Gene location: 1p35.3 (28236090: 28238104)     Exons: 3     NC_000001.11
• Gene summary(Entrez): This gene encodes a mitochondrial ATPase inhibitor. Alternative splicing occurs at this locus and three transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
• OMIM: 614981

Protein Summary

• Protein general information: Q9UII2  
  • Name: ATPase inhibitor, mitochondrial (ATP synthase F1 subunit epsilon) (Inhibitor of F(1)F(o) ATPase) (IF(1)) (IF1)
  • Length: 106  
  • Mass: 12249
• Sequence:

  MAVTALAARTWLGVWGVRTMQARGFGSDQSENVDRGAGSIREAGGAFGKREQAEEERYFRAQSREQLAALKKHHE
  EEIVHHKKEIERLQKEIERHKQKIKMLKHDD

• Structural information:
  • Interpro: IPR007648  
  • STRING: ENSP00000335203
• Other Databases: GeneCards:  ATP5IF1  Malacards:  ATP5IF1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0042803	protein homodimerization activity	TAS	molecular function
GO:1904925	positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization	IMP	biological process
GO:1903578	regulation of ATP metabolic process	IMP	biological process
GO:0042030	ATPase inhibitor activity	IMP	molecular function
GO:0032780	negative regulation of ATPase activity	IMP	biological process
GO:1903214	regulation of protein targeting to mitochondrion	IMP	biological process
GO:1903052	positive regulation of proteolysis involved in cellular protein catabolic process	IMP	biological process
GO:0051882	mitochondrial depolarization	IMP	biological process
GO:0005739	mitochondrion	IBA	cellular component
GO:0006783	heme biosynthetic process	IBA	biological process
GO:0042030	ATPase inhibitor activity	IBA	molecular function
GO:0051117	ATPase binding	IBA	molecular function
GO:0032780	negative regulation of ATPase activity	IBA	biological process
GO:0030218	erythrocyte differentiation	IMP	biological process
GO:0006783	heme biosynthetic process	IMP	biological process
GO:0032780	negative regulation of ATPase activity	IEA	biological process
GO:0005739	mitochondrion	IEA	cellular component
GO:0042030	ATPase inhibitor activity	IEA	molecular function
GO:0005739	mitochondrion	IEA	cellular component
GO:0004857	enzyme inhibitor activity	TAS	molecular function
GO:0005739	mitochondrion	TAS	cellular component
GO:0006091	generation of precursor metabolites and energy	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0042030	ATPase inhibitor activity	IEA	molecular function
GO:0005739	mitochondrion	IEA	cellular component
GO:0072593	reactive oxygen species metabolic process	IEA	biological process
GO:0006783	heme biosynthetic process	IEA	biological process
GO:1901030	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	IEA	biological process
GO:0030218	erythrocyte differentiation	IEA	biological process
GO:0005739	mitochondrion	IEA	cellular component
GO:0005739	mitochondrion	IDA	cellular component
GO:0019899	enzyme binding	IPI	molecular function
GO:0019899	enzyme binding	IPI	molecular function
GO:0043532	angiostatin binding	IDA	molecular function
GO:0001937	negative regulation of endothelial cell proliferation	IDA	biological process
GO:0051346	negative regulation of hydrolase activity	IDA	biological process
GO:0051117	ATPase binding	IDA	molecular function
GO:0140260	mitochondrial proton-transporting ATP synthase complex binding	IDA	molecular function
GO:0005739	mitochondrion	IDA	cellular component
GO:0042030	ATPase inhibitor activity	IDA	molecular function
GO:0042030	ATPase inhibitor activity	IDA	molecular function
GO:0009986	cell surface	IDA	cellular component
GO:0042802	identical protein binding	ISS	molecular function
GO:0051117	ATPase binding	ISS	molecular function
GO:0042030	ATPase inhibitor activity	ISS	molecular function
GO:0005516	calmodulin binding	ISS	molecular function
GO:0032991	protein-containing complex	ISS	cellular component
GO:0001525	angiogenesis	TAS	biological process
GO:0005739	mitochondrion	HDA	cellular component
GO:0051346	negative regulation of hydrolase activity	ISS	biological process
GO:0005739	mitochondrion	ISS	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Hypospermatogenesis	MIK: 28361989
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28361989	Hypospermatogenesis			6 (3 controls, 3 Klienfelter syndrome	Male infertility	Microarray
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R