• Gene id: 9379

Gene Summary

• Gene Symbol: NRXN2   Gene   UCSC   Ensembl
• Gene name: neurexin 2
• Alternate names: neurexin-2-beta, neurexin II,
• Gene location: 11q13.1 (64723196: 64606173)     Exons: 28     NC_000011.10
• Gene summary(Entrez): This gene encodes a member of the neurexin gene family. The products of these genes function as cell adhesion molecules and receptors in the vertebrate nervous system. These genes utilize two promoters. The majority of transcripts are produced from the up
• OMIM: 600566

Protein Summary

• Protein general information: P58401  
  • Name: Neurexin 2 beta (Neurexin II beta)
  • Length: 666  
  • Mass: 70927
• Sequence:

  MPPGGSGPGGCPRRPPALAGPLPPPPPPPPPPLLPLLPLLLLLLLGAAEGARVSSSLSTTHHVHHFHSKHGTVPI
  AINRMPFLTRGGHAGTTYIFGKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHID
  QGTVGVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGNFDNERLAIARQRIPYRL
  GRVVDEWLLDKGRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYYNGLKVLALAAESDPNVRTEGHLRLVGEGPSV
  LLSAETTATTLLADMATTIMETTTTMATTTTRRGRSPTLRDSTTQNTDDLLVASAECPSDDEDLEECEPSTGGEL
  ILPIITEDSLDPPPVATRSPFVPPPPTFYPFLTGVGATQDTLPPPAARRPPSGGPCQAERDDSDCEEPIEASGFA
  SGEVFDSSLPPTDDEDFYTTFPLVTDRTTLLSPRKPAPRPNLRTDGATGAPGVLFAPSAPAPNLPAGKMNHRDPL
  QPLLENPPLGPGAPTSFEPRRPPPLRPGVTSAPGFPHLPTANPTGPGERGPPGAVEVIRESSSTTGMVVGIVAAA
  ALCILILLYAMYKYRNRDEGSYQVDQSRNYISNSAQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV

• Structural information:
  • Protein Domains: (91..29-)
    (/note="Laminin-G-like)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00122"-)
  • Interpro: IPR013320  IPR001791  IPR003585  IPR027789  
  • Prosite: PS50025
  • PDB: 4NXR
  • PDBsum: 4NXR
• Other Databases: GeneCards:  NRXN2  Malacards:  NRXN2
• Protein general information: Q9P2S2  
  
  Name: Neurexin 2 (Neurexin II alpha) (Neurexin 2 alpha)
  
  Length: 1712  Mass: 184982
  
  Tissue specificity: Predominantly expressed in brain.
• Sequence: MASGSRWRPTPPPLLLLLLLALAARADGLEFGGGPGQWARYARWAGAASSGELSFSLRTNATRALLLYLDDGGDC
  DFLELLLVDGRLRLRFTLSCAEPATLQLDTPVADDRWHMVLLTRDARRTALAVDGEARAAEVRSKRREMQVASDL
  FVGGIPPDVRLSALTLSTVKYEPPFRGLLANLKLGERPPALLGSQGLRGATADPLCAPARNPCANGGLCTVLAPG
  EVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEVGSLLFSEGGAGRGGAGDVHQPTKGKEEFVATFKGNEFFCY
  DLSHNPIQSSTDEITLAFRTLQRNGLMLHTGKSADYVNLSLKSGAVWLVINLGSGAFEALVEPVNGKFNDNAWHD
  VRVTRNLRQHAGIGHAMVNKLHYLVTISVDGILTTTGYTQEDYTMLGSDDFFYIGGSPNTADLPGSPVSNNFMGC
  LKDVVYKNNDFKLELSRLAKEGDPKMKLQGDLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTE
  PNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRKG
  SISVNSRSTPFLATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDLRGLAE
  AQGAVGVAPFCSRETLKQCASAPCRNGGVCREGWNRFICDCIGTGFLGRVCEREATVLSYDGSMYMKIMLPNAMH
  TEAEDVSLRFMSQRAYGLMMATTSRESADTLRLELDGGQMKLTVNLDCLRVGCAPSKGPETLFAGHKLNDNEWHT
  VRVVRRGKSLQLSVDNVTVEGQMAGAHMRLEFHNIETGIMTERRFISVVPSNFIGHLSGLVFNGQPYMDQCKDGD
  ITYCELNARFGLRAIVADPVTFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNSGNGNDFIVIELVKGYI
  HYVFDLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDSRTVTQHSNGARNLDLKGELYIGGLSKNMFS
  NLPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCDGPSTTCTEESCANQGVCLQQWDGFTCDCTMT
  SYGGPVCNDPGTTYIFGKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGTV
  GVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGNFDNERLAIARQRIPYRLGRVV
  DEWLLDKGRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYYNGLKVLALAAESDPNVRTEGHLRLVGEGPSVLLSA
  ETTATTLLADMATTIMETTTTMATTTTRRGRSPTLRDSTTQNTDDLLVASAECPSDDEDLEECEPSTGGELILPI
  ITEDSLDPPPVATRSPFVPPPPTFYPFLTGVGATQDTLPPPAARRPPSGGPCQAERDDSDCEEPIEASGFASGEV
  FDSSLPPTDDEDFYTTFPLVTDRTTLLSPRKPAPRPNLRTDGATGAPGVLFAPSAPAPNLPAGKMNHRDPLQPLL
  ENPPLGPGAPTSFEPRRPPPLRPGVTSAPGFPHLPTANPTGPGERGPPGAVEVIRESSSTTGMVVGIVAAAALCI
  LILLYAMYKYRNRDEGSYQVDQSRNYISNSAQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV
• Structural information:

  Protein Domains	(29..20-) 1 (/note="Laminin-G-like) (/evidence="ECO:0000255|PROSITE-ProRule:PRU00122-) (202..24-) (/note="EGF-like-1) (/evidence="ECO:0000255|PROSITE-ProRule:PRU00076-) (289..48-) 2 (/note="Laminin-G-like) (/evidence="ECO:0000255|PROS-)
  Interpro:	IPR013320  IPR000742  IPR001791  IPR003585  IPR027789
  Prosite:	PS50026 PS50025
  MINT:
  STRING:	ENSP00000265459

• Other Databases: GeneCards:  NRXN2  Malacards:  NRXN2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0046872	metal ion binding	IEA	molecular function
GO:0016021	integral component of membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0007155	cell adhesion	IEA	biological process
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0007165	signal transduction	ISS	biological process
GO:0007269	neurotransmitter secretion	ISS	biological process
GO:0097118	neuroligin clustering involved in postsynaptic membrane assembly	ISS	biological process
GO:0004888	transmembrane signaling receptor activity	ISS	molecular function
GO:0050839	cell adhesion molecule binding	ISS	molecular function
GO:0097104	postsynaptic membrane assembly	ISS	biological process
GO:0005246	calcium channel regulator activity	ISS	molecular function
GO:0097109	neuroligin family protein binding	ISS	molecular function
GO:0007158	neuron cell-cell adhesion	TAS	biological process
GO:0035176	social behavior	IMP	biological process
GO:0030534	adult behavior	IMP	biological process
GO:0042297	vocal learning	IMP	biological process
GO:0071625	vocalization behavior	IMP	biological process
GO:0007268	chemical synaptic transmission	ISS	biological process
GO:0097119	postsynaptic density protein 95 clustering	ISS	biological process
GO:0007416	synapse assembly	ISS	biological process
GO:0097116	gephyrin clustering involved in postsynaptic density assembly	ISS	biological process
GO:0016020	membrane	IEA	cellular component
GO:0098793	presynapse	IEA	cellular component
GO:0045202	synapse	IEA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa04514	Cell adhesion molecules

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq