• Gene id: 93550

Gene Summary

• Gene Symbol: ZFAND4   Gene   UCSC   Ensembl
• Aliases: ANUBL1
• Gene name: zinc finger AN1-type containing 4
• Alternate names: AN1-type zinc finger protein 4, AN1, ubiquitin-like, homolog, AN1-type zinc finger and ubiquitin domain-containing protein 1, AN1-type zinc finger and ubiquitin domain-containing protein-like 1, zinc finger, AN1-type domain 4,
• Gene location: 10q11.22 (45672961: 45614566)     Exons: 18     NC_000010.11
• OMIM: 0

Protein Summary

• Protein general information: Q86XD8  
  • Name: AN1 type zinc finger protein 4 (AN1 type zinc finger and ubiquitin domain containing protein like 1)
  • Length: 727  
  • Mass: 80358
• Sequence:

  MDNRKEPPFFNDDNMGPFYYRLHFCDTMELFIETLTGTCFELRVSPFETVISVKAKIRRLEGIPICRQHLIWNNM
  ELENDYCLNDYNISEGCTLKLVLAMRGGPINTRRVPTDDPLRKMAEYLDSSRVEVWEKTSCSKQVTFLVYQEGDQ
  LNFFPAVDRGDGTLTPLSDSSKKIDFHLHVLRRKGEHRMSGGSMYNSDTDEDEETEPSSSGQQIIENSITMNKMK
  LLKAKMKNMNLSKKPKKAVKIKPHPPVAPRPSSGSTAPSRHRLLRVLPNIGQSCSPAFGNAYPPEISRNGISSLA
  TQLSAERYISSITGEFLKEDNSWENNTLSHFSSNVKLPPQIPHLELGNDQELADSVLHLGSSLPRQTKHFLGNLP
  SSNGNIVLPSEECVTEQSLLPKVGSLASFAEGNADEQSSGLEGACKVNLELLLTNADKGLKAPEQHLKHVAGVLN
  GESVETSVLNYRELSPHKNRLLSPLRCSAPMSLHNSLVKPERQSKCFEFGKLQPSSSQSLDVQNITDSSFSRTTC
  FQGVKVDSLGKRSDVISKVEARDITEMTNKASKEPVGCVNNISFLASLAGSTSRNRLQSTRGAGRLQNSGTGLST
  NLQHFQEENFRKSSPQLEHTGVFLSTHGVGMNGNNAAAGKSVGECTTHHLPPVKAPLQTKKKTTNHCFLCGKKTG
  LASSYECRCGNNFCASHRYAETHGCTYDYKSAGRRYLHEANPVVNAPKLPKI

• Structural information:
  • Protein Domains: (28..10-)
    (/note="Ubiquitin-like-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00214"-)
  • Interpro: IPR035896  IPR000626  IPR029071  IPR019956  IPR000058  
  • Prosite: PS50053 PS51039
  • STRING: ENSP00000339484
• Other Databases: GeneCards:  ZFAND4  Malacards:  ZFAND4

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0008270	zinc ion binding	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
31037746	Spermatogenic defects			28 men with azoospermia	Male infertility	Microarray
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R