• Gene id: 9352

Gene Summary

• Gene Symbol: TXNL1   Gene   UCSC   Ensembl
• Aliases: HEL-S-114, TRP32, TXL-1, TXNL, Txl
• Gene name: thioredoxin like 1
• Alternate names: thioredoxin-like protein 1, 32 kDa thioredoxin-related protein, epididymis secretory protein Li 114, thioredoxin-related 32 kDa protein, thioredoxin-related protein 1,
• Gene location: 18q21.31 (56638634: 56597208)     Exons: 46     NC_000018.10
• OMIM: 603049

Protein Summary

• Protein general information: O43396  
  • Name: Thioredoxin like protein 1 (32 kDa thioredoxin related protein)
  • Length: 289  
  • Mass: 32251
  • Tissue specificity: Ubiquitous.
• Sequence:

  MVGVKPVGSDPDFQPELSGAGSRLAVVKFTMRGCGPCLRIAPAFSSMSNKYPQAVFLEVDVHQCQGTAATNNISA
  TPTFLFFRNKVRIDQYQGADAVGLEEKIKQHLENDPGSNEDTDIPKGYMDLMPFINKAGCECLNESDEHGFDNCL
  RKDTTFLESDCDEQLLITVAFNQPVKLYSMKFQGPDNGQGPKYVKIFINLPRSMDFEEAERSEPTQALELTEDDI
  KEDGIVPLRYVKFQNVNSVTIFVQSNQGEEETTRISYFTFIGTPVQATNMNDFKRVVGKKGESH

• Structural information:
  • Protein Domains: (2..10-)
    (/note="Thioredoxin-)
    (115..28-)
    (/note="PITH-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00864"-)
  • Interpro: IPR008979  IPR010400  IPR037047  IPR036249  IPR017937   IPR013766  
  • Prosite: PS51532 PS00194
  • PDB: 1GH2 1WWY
  • PDBsum: 1GH2 1WWY
  • STRING: ENSP00000217515
• Other Databases: GeneCards:  TXNL1  Malacards:  TXNL1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0045454	cell redox homeostasis	IEA	biological process
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0000502	proteasome complex	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0015036	disulfide oxidoreductase activity	IDA	molecular function
GO:0005737	cytoplasm	IDA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881