• Gene id: 93492

Gene Summary

• Gene Symbol: TPTE2   Gene   UCSC   Ensembl
• Aliases: TPIP
• Gene name: transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
• Alternate names: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2, PTEN-like inositol lipid phosphatase, TPIP lipid phosphatase, TPTE and PTEN homologous inositol lipid phosphatase, lipid phosphatase TPIP, transmembrane phosphoinositide 3-phosphatase and tensin 2-l,
• Gene location: 13q12.11 (19561573: 19422876)     Exons: 26     NC_000013.11
• Gene summary(Entrez): TPIP is a member of a large class of membrane-associated phosphatases with substrate specificity for the 3-position phosphate of inositol phospholipids.[supplied by OMIM, Jul 2002]

Protein Summary

• Protein general information: Q6XPS3  
  • Name: Phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase TPTE2 (EC 3.1.3.67) (Lipid phosphatase TPIP) (TPTE and PTEN homologous inositol lipid phosphatase)
  • Length: 522  
  • Mass: 61112
  • Tissue specificity: Isoform 3 is expressed in testis, brain and stomach while isoform 4 seems to be testis-specific. {ECO
• Sequence:

  MNESPQTNEFKGTTEEAPAKESPHTSEFKGAALVSPISKSMLERLSKFEVEDAENVASYDSKIKKIVHSIVSSFA
  FGIFGVFLVLLDVTLLLADLIFTDSKLYIPLEYRSISLAIGLFFLMDVLLRVFVEGRQQYFSDLFNILDTAIIVI
  PLLVDVIYIFFDIKLLRNIPRWTHLVRLLRLIILIRIFHLLHQKRQLEKLMRRLVSENKRRYTRDGFDLDLTYVT
  ERIIAMSFPSSGRQSFYRNPIEEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVSRIMIDDHNVPTLHEMVVF
  TKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCALLIASEIFLTAEESLYYFGERRTNKTHSNKFQGVETPSQNRY
  VGYFAQVKHLYNWNLPPRRILFIKRFIIYSIRGDVCDLKVQVVMEKKVVFSSTSLGNCSILHDIETDKILINVYD
  GPPLYDDVKVQFFSSNLPKYYDNCPFFFWFNTSFIQNNRLCLPRNELDNPHKQKAWKIYPPEFAVEILFGEK

• Structural information:
  • Protein Domains: (210..38-)
    (/note="Phosphatase-tensin-type)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00590-)
    (393..52-)
    (/note="C2-tensin-type)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00589"-)
  • Interpro: IPR000340  IPR029021  IPR014020  IPR029023  IPR016130   IPR027359  
  • Prosite: PS51182 PS51181
  • STRING: ENSP00000383089
• Other Databases: GeneCards:  TPTE2  Malacards:  TPTE2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005829	cytosol	IBA	cellular component
GO:0016311	dephosphorylation	IBA	biological process
GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	IBA	molecular function
GO:0004725	protein tyrosine phosphatase activity	IEA	molecular function
GO:0016311	dephosphorylation	IEA	biological process
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0005794	Golgi apparatus	IEA	cellular component
GO:0005783	endoplasmic reticulum	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	IEA	molecular function
GO:0006661	phosphatidylinositol biosynthetic process	TAS	biological process
GO:0000139	Golgi membrane	TAS	cellular component
GO:0000139	Golgi membrane	IEA	cellular component
GO:0005789	endoplasmic reticulum membrane	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0035335	peptidyl-tyrosine dephosphorylation	IEA	biological process
GO:0006470	protein dephosphorylation	IEA	biological process

Diseases

Associated diseases	References
Spermatogenic defects	MIK: 31037746

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
31037746	Spermatogenic defects			28 men with azoospermia	Male infertility	Microarray