• Gene id: 9349

Gene Summary

• Gene Symbol: RPL23   Gene   UCSC   Ensembl
• Aliases: L23, rpL17
• Gene name: ribosomal protein L23
• Alternate names: 60S ribosomal protein L23, 60S ribosomal protein L17, large ribosomal subunit protein uL14, ribosomal protein L17,
• Gene location: 17q12 (38853720: 38847859)     Exons: 5     NC_000017.11
• Gene summary(Entrez): Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal pro
• OMIM: 614442

Protein Summary

• Protein general information: P62829  
  • Name: 60S ribosomal protein L23 (60S ribosomal protein L17) (Large ribosomal subunit protein uL14)
  • Length: 140  
  • Mass: 14865
• Sequence:

  MSKRGRGGSSGAKFRISLGLPVGAVINCADNTGAKNLYIISVKGIKGRLNRLPAAGVGDMVMATVKKGKPELRKK
  VHPAVVIRQRKSYRRKDGVFLYFEDNAGVIVNNKGEMKGSAITGPVAKECADLWPRIASNAGSIA

• Structural information:
  • Interpro: IPR036853  IPR000218  IPR019972  
  • Prosite: PS00049
  • PDB: 4UG0 4V6X 5AJ0 5LKS 5T2C 6EK0 6IP5 6IP6 6IP8 6QZP
  • PDBsum: 4UG0 4V6X 5AJ0 5LKS 5T2C 6EK0 6IP5 6IP6 6IP8 6QZP
  • DIP: 33156
  • STRING: ENSP00000420311
• Other Databases: GeneCards:  RPL23  Malacards:  RPL23

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0003735	structural constituent of ribosome	IBA	molecular function
GO:0022625	cytosolic large ribosomal subunit	IBA	cellular component
GO:0070180	large ribosomal subunit rRNA binding	IBA	molecular function
GO:0005840	ribosome	IEA	cellular component
GO:0006412	translation	IEA	biological process
GO:0003735	structural constituent of ribosome	IEA	molecular function
GO:0005840	ribosome	IEA	cellular component
GO:0006413	translational initiation	TAS	biological process
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	TAS	biological process
GO:0019083	viral transcription	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005730	nucleolus	IEA	cellular component
GO:0022625	cytosolic large ribosomal subunit	IEA	cellular component
GO:0005840	ribosome	IEA	cellular component
GO:0014069	postsynaptic density	IEA	cellular component
GO:0001223	transcription coactivator binding	IPI	molecular function
GO:0008284	positive regulation of cell population proliferation	IMP	biological process
GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process	IDA	biological process
GO:0032991	protein-containing complex	IMP	cellular component
GO:1904667	negative regulation of ubiquitin protein ligase activity	IDA	biological process
GO:0005737	cytoplasm	IDA	cellular component
GO:0010628	positive regulation of gene expression	IMP	biological process
GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	biological process
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005730	nucleolus	IDA	cellular component
GO:0005730	nucleolus	IDA	cellular component
GO:1901798	positive regulation of signal transduction by p53 class mediator	IMP	biological process
GO:0050821	protein stabilization	IMP	biological process
GO:0050821	protein stabilization	IMP	biological process
GO:0071157	negative regulation of cell cycle arrest	IMP	biological process
GO:0071158	positive regulation of cell cycle arrest	IMP	biological process
GO:0072717	cellular response to actinomycin D	IMP	biological process
GO:0032991	protein-containing complex	IDA	cellular component
GO:0031625	ubiquitin protein ligase binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:1990948	ubiquitin ligase inhibitor activity	IDA	molecular function
GO:0032986	protein-DNA complex disassembly	IDA	biological process
GO:0003735	structural constituent of ribosome	NAS	molecular function
GO:0016020	membrane	HDA	cellular component
GO:0006412	translation	NAS	biological process
GO:0005840	ribosome	NAS	cellular component
GO:0003723	RNA binding	HDA	molecular function
GO:0005925	focal adhesion	HDA	cellular component
GO:0022625	cytosolic large ribosomal subunit	HDA	cellular component
GO:0006610	ribosomal protein import into nucleus	NAS	biological process
GO:0070062	extracellular exosome	HDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa03010	Ribosome

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881