• Gene id: 93408

Gene Summary

• Gene Symbol: MYL10   Gene   UCSC   Ensembl
• Aliases: MYLC2PL, PLRLC
• Gene name: myosin light chain 10
• Alternate names: myosin regulatory light chain 10, myosin light chain 2, lymphocyte-specific, myosin light chain 2, precursor lymphocyte-specific, myosin, light chain 10, regulatory, precursor lymphocyte-specific regulatory light chain,
• Gene location: 7q22.1 (101629295: 101613329)     Exons: 9     NC_000007.14
• OMIM: 617177

Protein Summary

• Protein general information: Q9BUA6  
  • Name: Myosin regulatory light chain 10 (Myosin light chain 2, lymphocyte specific) (Precursor lymphocyte specific regulatory light chain)
  • Length: 226  
  • Mass: 25308
• Sequence:

  MLLRLVSNSWPQVILPPRPPKVLGLQAPRRARKRAEGTASSNVFSMFDQSQIQEFKESLALSPRLERNGMISAHC
  NLCLTGSSNSPASASQAFTIMDQNRDGFIDKEDLRDTFAALGRINVKNEELEAMVKEAPGPINFTVFLTMFGEKL
  KGTDPEETILHAFKVFDTEGKGFVKADVIKEKLMTQADRFSEEEVKQMFAAFPPDVCGNLDYRNLCYVITHGEEK
  D

• Structural information:
  • Protein Domains: (84..11-)
    (/note="EF-hand-1)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00448-)
    (154..18-)
    (/note="EF-hand-2)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00448-)
    (190..22-)
    (/note="EF-hand-3)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU-)
  • Interpro: IPR011992  IPR018247  IPR002048  
  • Prosite: PS00018 PS50222
  • STRING: ENSP00000223167
• Other Databases: GeneCards:  MYL10  Malacards:  MYL10

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005509	calcium ion binding	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0006936	muscle contraction	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005739	mitochondrion	IDA	cellular component
GO:0005515	protein binding	IPI	molecular function

KEGG pathways

Pathway id	Pathway name
hsa05131	Shigellosis
hsa04810	Regulation of actin cytoskeleton
hsa04510	Focal adhesion
hsa04670	Leukocyte transendothelial migration

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq