• Gene id: 9328

Gene Summary

• Gene Symbol: GTF3C5   Gene   UCSC   Ensembl
• Aliases: TFIIIC63, TFIIICepsilon, TFiiiC2-63
• Gene name: general transcription factor IIIC subunit 5
• Alternate names: general transcription factor 3C polypeptide 5, TF3C-epsilon, TFIIIC 63 kDa subunit, general transcription factor IIIC, polypeptide 5, 63kDa, transcription factor IIIC 63 kDa subunit, transcription factor IIIC subunit epsilon, transcription factor IIIC, 63 kD,
• Gene location: 9q34.13 (133030674: 133058502)     Exons: 11     NC_000009.12

SNPs

rs10762738

Strand:    Allele origin:   Allele change:   Mutation type: snv

NC_000010.11   g.76935709A>G
NC_000010.10   g.78695467A>G
NG_012270.1   g.707111T>C|SEQ=[A/G]|GENE=KCNMA1
KCNMA1-AS1   101929328

Protein Summary

• Protein general information: Q9Y5Q8  
  • Name: General transcription factor 3C polypeptide 5 (TF3C epsilon) (Transcription factor IIIC 63 kDa subunit) (TFIIIC 63 kDa subunit) (TFIIIC63) (Transcription factor IIIC subunit epsilon)
  • Length: 519  
  • Mass: 59571
• Sequence:

  MAAEAADLGLGAAVPVELRRERRMVCVEYPGVVRDVAKMLPTLGGEEGVSRIYADPTKRLELYFRPKDPYCHPVC
  ANRFSTSSLLLRIRKRTRRQKGVLGTEAHSEVTFDMEILGIISTIYKFQGMSDFQYLAVHTEAGGKHTSMYDKVL
  MLRPEKEAFFHQELPLYIPPPIFSRLDAPVDYFYRPETQHREGYNNPPISGENLIGLSRARRPHNAIFVNFEDEE
  VPKQPLEAAAQTWRRVCTNPVDRKVEEELRKLFDIRPIWSRNAVKANISVHPDKLKVLLPFIAYYMITGPWRSLW
  IRFGYDPRKNPDAKIYQVLDFRIRCGMKHGYAPSDLPVKAKRSTYNYSLPITVKKTSSQLVTMHDLKQGLGPSGT
  SGARKPASSKYKLKDSVYIFREGALPPYRQMFYQLCDLNVEELQKIIHRNDGAENSCTERDGWCLPKTSDELRDT
  MSLMIRQTIRSKRPALFSSSAKADGGKEQLTYESGEDEEDEEEEEEEEEDFKPSDGSENEMETEILDYV

• Structural information:
  • Interpro: IPR019136  IPR040454  IPR041499  IPR042536  
  • DIP: 50823
  • STRING: ENSP00000361180
• Other Databases: GeneCards:  GTF3C5  Malacards:  GTF3C5

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0006383	transcription by RNA polymerase III	IC	biological process
GO:0003677	DNA binding	IC	contributes to
GO:0042797	tRNA transcription by RNA polymerase III	IC	biological process
GO:0000127	transcription factor TFIIIC complex	IDA	cellular component
GO:0042791	5S class rRNA transcription by RNA polymerase III	IC	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0000127	transcription factor TFIIIC complex	IBA	cellular component
GO:0000127	transcription factor TFIIIC complex	IEA	cellular component
GO:0006384	transcription initiation from RNA polymerase III promoter	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0003677	DNA binding	IEA	molecular function
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0035914	skeletal muscle cell differentiation	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Hypospermatogenesis	MIK: 28361989

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
28361989	Hypospermatogenesis			6 (3 controls, 3 Klienfelter syndrome	Male infertility	Microarray