• Gene id: 9321

Gene Summary

• Gene Symbol: TRIP11   Gene   UCSC   Ensembl
• Aliases: ACG1A, CEV14, GMAP-210, GMAP210, ODCD, TRIP-11, TRIP230
• Gene name: thyroid hormone receptor interactor 11
• Alternate names: thyroid receptor-interacting protein 11, Golgi-microtubule-associated protein of 210 kDa, TR-interacting protein 11, clonal evolution-related gene on chromosome 14 protein, golgi-associated microtubule-binding protein 210,
• Gene location: 14q32.12 (92040133: 91965990)     Exons: 15     NC_000014.9
• Gene summary(Entrez): This gene was identified based on the interaction of its protein product with thyroid hormone receptor beta. This protein is associated with the Golgi apparatus. The N-terminal region of the protein binds Golgi membranes and the C-terminal region binds th
• OMIM: 604505

Protein Summary

• Protein general information: Q15643  
  • Name: Thyroid receptor interacting protein 11 (TR interacting protein 11) (TRIP 11) (Clonal evolution related gene on chromosome 14 protein) (Golgi associated microtubule binding protein 210) (GMAP 210) (Trip230)
  • Length: 1979  
  • Mass: 227586
  • Tissue specificity: Highly expressed in pancreas, muscle, heart, testis, peripheral blood leukocytes, and in several leukemia cell lines. Detected at intermediate levels in placenta and kidney, and at low levels in brain and lung. Isoform 1 and isoform 2
• Sequence:

  MSSWLGGLGSGLGQSLGQVGGSLASLTGQISNFTKDMLMEGTEEVEAELPDSRTKEIEAIHAILRSENERLKKLC
  TDLEEKHEASEIQIKQQSTSYRNQLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGI
  SHHPSAFHDDDMDFGDIISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQNIIKELKQNR
  SQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIETDLSKIYEMQKTIQVLQIE
  KVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKE
  RILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNN
  EYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEG
  DSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNV
  SIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDV
  KMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNAR
  NLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSS
  KLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQ
  LNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQI
  KTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLS
  KDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDI
  VAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVN
  SNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYE
  QNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELE
  ELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLS
  SNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFEC
  HSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEF
  RSNQELERLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSK
  QRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECLDE
  ANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKLMSLANSSEGKVDKVLMRNLFIGHFHTPKNQRH
  EVLRLMGSILGVRREEMEQLFHDDQGGVTRWMTGWLGGGSKSVPNTPLRPNQQSVVNSSFSELFVKFLETESHPS
  IPPPKLSVHDMKPLDSPGRRKRDTNAPESFKDTAESRSGRRTDVNPFLAPRSAAVPLINPAGLGPGGPGHLLLKP
  ISDVLPTFTPLPALPDNSAGVVLKDLLKQ

• Structural information:
  • Protein Domains: (1774..182-)
    (/note="GRIP-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00250"-)
  • Interpro: IPR000237  
  • Prosite: PS50913
  • DIP: 40357
  • STRING: ENSP00000267622
• Other Databases: GeneCards:  TRIP11  Malacards:  TRIP11

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	IDA	cellular component
GO:0099041	vesicle tethering to Golgi	IMP	biological process
GO:0090161	Golgi ribbon formation	IMP	biological process
GO:0051216	cartilage development	IMP	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005794	Golgi apparatus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005856	cytoskeleton	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0003713	transcription coactivator activity	TAS	molecular function
GO:0006366	transcription by RNA polymerase II	TAS	biological process
GO:0030133	transport vesicle	TAS	cellular component
GO:0035735	intraciliary transport involved in cilium assembly	TAS	biological process
GO:0000139	Golgi membrane	TAS	cellular component
GO:0002081	outer acrosomal membrane	IEA	cellular component
GO:0060122	inner ear receptor cell stereocilium organization	IEA	biological process
GO:0006486	protein glycosylation	IEA	biological process
GO:0005801	cis-Golgi network	IEA	cellular component
GO:0002079	inner acrosomal membrane	IEA	cellular component
GO:0060348	bone development	IEA	biological process
GO:0007030	Golgi organization	IEA	biological process
GO:0003413	chondrocyte differentiation involved in endochondral bone morphogenesis	IEA	biological process
GO:0003281	ventricular septum development	IEA	biological process
GO:0002080	acrosomal membrane	IEA	cellular component
GO:0005794	Golgi apparatus	IEA	cellular component
GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane	IEA	cellular component
GO:0005856	cytoskeleton	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0016607	nuclear speck	IDA	cellular component
GO:0005794	Golgi apparatus	IDA	cellular component
GO:0005929	cilium	IEA	cellular component
GO:1903508	positive regulation of nucleic acid-templated transcription	IEA	biological process
GO:0005515	protein binding	IPI	molecular function

Diseases

Associated diseases	References
Achondrogenesis type IA	KEGG:H00678
Odontochondrodysplasia	KEGG:H02349
Achondrogenesis type IA	KEGG:H00678
Odontochondrodysplasia	KEGG:H02349
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881