• Gene id: 93082

Gene Summary

• Gene Symbol: NEURL3   Gene   UCSC   Ensembl
• Aliases: LINCR, RNF132
• Gene name: neuralized E3 ubiquitin protein ligase 3
• Alternate names: E3 ubiquitin-protein ligase NEURL3, RING-type E3 ubiquitin transferase NEURL3, lung-inducible neuralized-related C3CH4 RING domain protein, neuralized homolog 3 pseudogene, neuralized-like protein 3,
• Gene location: 2q11.2 (96508156: 96497642)     Exons: 7     NC_000002.12
• OMIM: 617747

Protein Summary

• Protein general information: Q96EH8  
  • Name: E3 ubiquitin protein ligase NEURL3 (EC 2.3.2.27) (Lung inducible neuralized related C3CH4 RING domain protein) (Neuralized like protein 3) (RING type E3 ubiquitin transferase NEURL3)
  • Length: 262  
  • Mass: 28789
• Sequence:

  MGAQLCFEANAKAPREALRFHAEAKGAQVRLDTRGCIAHRRTTFHDGIVFSQRPVRLGERVALRVLREESGWCGG
  LRVGFTRLDPACVSVPSLPPFLCPDLEEQSPTWAAVLPEGCALTGDLVRFWVDRRGCLFAKVNAGCRLLLREGVP
  VGAPLWAVMDVYGTTKAIELLDPTASRLPTPMPWDLSNKAVPEPKATPGEECAICFYHAANTRLVPCGHTYFCRY
  CAWRVFSDTAKCPVCRWQIEAVAPAQGPPALRVEEGS

• Structural information:
  • Protein Domains: (17..17-)
    (/note="NHR-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00400"-)
  • Interpro: IPR037962  IPR006573  IPR001841  IPR013083  
  • Prosite: PS51065 PS50089
  • STRING: ENSP00000478591
• Other Databases: GeneCards:  NEURL3  Malacards:  NEURL3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0061630	ubiquitin protein ligase activity	IBA	molecular function
GO:0005769	early endosome	IBA	cellular component
GO:0070086	ubiquitin-dependent endocytosis	IBA	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0061630	ubiquitin protein ligase activity	IEA	molecular function
GO:0016567	protein ubiquitination	IEA	biological process
GO:0016567	protein ubiquitination	IEA	biological process

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq