• Gene id: 92714

Gene Summary

• Gene Symbol: ARRDC1   Gene   UCSC   Ensembl
• Gene name: arrestin domain containing 1
• Alternate names: arrestin domain-containing protein 1, alpha-arrestin 1,
• Gene location: 9q34.3 (137605639: 137615359)     Exons: 9     NC_000009.12
• OMIM: 139314

Protein Summary

• Protein general information: Q8N5I2  
  • Name: Arrestin domain containing protein 1 (Alpha arrestin 1)
  • Length: 433  
  • Mass: 45981
• Sequence:

  MGRVQLFEISLSHGRVVYSPGEPLAGTVRVRLGAPLPFRAIRVTCIGSCGVSNKANDTAWVVEEGYFNSSLSLAD
  KGSLPAGEHSFPFQFLLPATAPTSFEGPFGKIVHQVRAAIHTPRFSKDHKCSLVFYILSPLNLNSIPDIEQPNVA
  SATKKFSYKLVKTGSVVLTASTDLRGYVVGQALQLHADVENQSGKDTSPVVASLLQKVSYKAKRWIHDVRTIAEV
  EGAGVKAWRRAQWHEQILVPALPQSALPGCSLIHIDYYLQVSLKAPEATVTLPVFIGNIAVNHAPVSPRPGLGLP
  PGAPPLVVPSAPPQEEAEAEAAAGGPHFLDPVFLSTKSHSQRQPLLATLSSVPGAPEPCPQDGSPASHPLHPPLC
  ISTGATVPYFAEGSGGPVPTTSTLILPPEYSSWGYPYEAPPSYEQSCGGVEPSLTPES

• Structural information:
  • Interpro: IPR011021  IPR014752  IPR011022  IPR014756  
  • STRING: ENSP00000360475
• Other Databases: GeneCards:  ARRDC1  Malacards:  ARRDC1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0015031	protein transport	IBA	biological process
GO:0005737	cytoplasm	IBA	cellular component
GO:1990756	ubiquitin ligase-substrate adaptor activity	IBA	molecular function
GO:0031625	ubiquitin protein ligase binding	IBA	molecular function
GO:0070062	extracellular exosome	IDA	NOT|cellular component
GO:1903561	extracellular vesicle	IDA	cellular component
GO:1903561	extracellular vesicle	IDA	cellular component
GO:0005886	plasma membrane	IDA	cellular component
GO:0005886	plasma membrane	IDA	cellular component
GO:0045746	negative regulation of Notch signaling pathway	IMP	biological process
GO:0006511	ubiquitin-dependent protein catabolic process	IMP	biological process
GO:0006511	ubiquitin-dependent protein catabolic process	IMP	NOT|biological process
GO:1990756	ubiquitin ligase-substrate adaptor activity	IMP	molecular function
GO:0031625	ubiquitin protein ligase binding	IPI	molecular function
GO:0006858	extracellular transport	IMP	biological process
GO:1990763	arrestin family protein binding	IPI	molecular function
GO:1990763	arrestin family protein binding	IPI	molecular function
GO:1990763	arrestin family protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0016567	protein ubiquitination	IMP	biological process
GO:0140112	extracellular vesicle biogenesis	IMP	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0015031	protein transport	IMP	biological process
GO:0005886	plasma membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0031410	cytoplasmic vesicle	IDA	cellular component
GO:0005886	plasma membrane	IDA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005886	plasma membrane	IEA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq