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Gene id |
9261 |
| Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed |
Gene Summary
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|
Gene Symbol |
MAPKAPK2 Gene UCSC Ensembl |
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Aliases |
MAPKAP-K2, MK-2, MK2 |
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Gene name |
MAPK activated protein kinase 2 |
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Alternate names |
MAP kinase-activated protein kinase 2, MAPKAP kinase 2, mitogen-activated protein kinase-activated protein kinase 2, |
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Gene location |
1q32.1 (206684904: 206734282) Exons: 11 NC_000007.14
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Gene summary(Entrez) |
This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress
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|
OMIM |
602006 |
Protein Summary
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| GO accession | Term name | Evidence code | Go category |
|---|
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| Pathway id | Pathway name |
|---|
| hsa04218 | Cellular senescence | | hsa04625 | C-type lectin receptor signaling pathway | | hsa04722 | Neurotrophin signaling pathway | | hsa05203 | Viral carcinogenesis | | hsa05167 | Kaposi sarcoma-associated herpesvirus infection | | hsa04010 | MAPK signaling pathway | | hsa05203 | Viral carcinogenesis | | hsa04218 | Cellular senescence | | hsa05167 | Kaposi sarcoma-associated herpesvirus infection | | hsa04722 | Neurotrophin signaling pathway | | hsa04625 | C-type lectin receptor signaling pathway | | hsa04370 | VEGF signaling pathway | |
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| Associated diseases |
References |
| Rheumatoid arthritis | GAD: 20805296 |
| Spermatogenesis defects | MIK: 27280388 |
| Spermatogenic defects | MIK: 27280388 |
| Male infertililty | MIK: 27280388 |
| Teratozoospermia | MIK: 17327269 |
|
|
| PMID |
Condition |
Mutation |
Ethnicity |
Population details |
Infertility_type |
Associated_genes |
Abstract |
| 27280388 |
Regulates
spermatoge
nesis, Mal
e infertil
ilty
|
|
|
|
Male infertility |
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Show abstract |
| 17327269 |
Teratozoos
permia
|
|
|
19 (6 controls
, 13 cases)
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Male infertility |
GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
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Show abstract |
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