• Gene id: 92483

Gene Summary

• Gene Symbol: LDHAL6B   Gene   UCSC   Ensembl
• Aliases: LDH6B, LDHAL6, LDHL
• Gene name: lactate dehydrogenase A like 6B
• Alternate names: L-lactate dehydrogenase A-like 6B, lactate dehydrogenase A-like 6, testicular tissue protein Li 105,
• Gene location: 15q22.2 (59206842: 59208587)     Exons: 1     NC_000015.10
• OMIM: 0

Protein Summary

• Protein general information: Q9BYZ2  
  • Name: L lactate dehydrogenase A like 6B (EC 1.1.1.27)
  • Length: 381  
  • Mass: 41943
  • Tissue specificity: Testis specific.
• Sequence:

  MSWTVPVVRASQRVSSVGANFLCLGMALCPRQATRIPLNGTWLFTPVSKMATVKSELIERFTSEKPVHHSKVSII
  GTGSVGMACAISILLKGLSDELALVDLDEDKLKGETMDLQHGSPFTKMPNIVCSKDYFVTANSNLVIITAGARQE
  KGETRLNLVQRNVAIFKLMISSIVQYSPHCKLIIVSNPVDILTYVAWKLSAFPKNRIIGSGCNLDTARFRFLIGQ
  KLGIHSESCHGWILGEHGDSSVPVWSGVNIAGVPLKDLNSDIGTDKDPEQWKNVHKEVTATAYEIIKMKGYTSWA
  IGLSVADLTESILKNLRRIHPVSTIIKGLYGIDEEVFLSIPCILGENGITNLIKIKLTPEEEAHLKKSAKTLWEI
  QNKLKL

• Structural information:
  • Interpro: IPR001557  IPR011304  IPR018177  IPR022383  IPR001236   IPR015955  IPR036291  
  • Prosite: PS00064
  • STRING: ENSP00000302393
• Other Databases: GeneCards:  LDHAL6B  Malacards:  LDHAL6B

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004459	L-lactate dehydrogenase activity	IBA	molecular function
GO:0004459	L-lactate dehydrogenase activity	IEA	molecular function
GO:0005975	carbohydrate metabolic process	IEA	biological process
GO:0019752	carboxylic acid metabolic process	IEA	biological process
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0003824	catalytic activity	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0016491	oxidoreductase activity	IEA	molecular function
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA	molecular function
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0016491	oxidoreductase activity	IEA	molecular function
GO:0004459	L-lactate dehydrogenase activity	IEA	molecular function
GO:0005759	mitochondrial matrix	TAS	cellular component
GO:0006090	pyruvate metabolic process	TAS	biological process
GO:0004459	L-lactate dehydrogenase activity	TAS	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005634	nucleus	HDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa04922	Glucagon signaling pathway
hsa04066	HIF-1 signaling pathway
hsa00010	Glycolysis / Gluconeogenesis
hsa05230	Central carbon metabolism in cancer
hsa00270	Cysteine and methionine metabolism
hsa00620	Pyruvate metabolism
hsa00640	Propanoate metabolism

Diseases

Associated diseases	References
Hypospermatogenesis	MIK: 28361989
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28361989	Hypospermatogenesis			6 (3 controls, 3 Klienfelter syndrome	Male infertility	Microarray