• Gene id: 92291

Gene Summary

• Gene Symbol: CAPN13   Gene   UCSC   Ensembl
• Gene name: calpain 13
• Alternate names: calpain-13, CANP 13, calcium-activated neutral proteinase 13,
• Gene location: 2p23.1 (30809526: 30722770)     Exons: 40     NC_000002.12
• Gene summary(Entrez): The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct
• OMIM: 610228

Protein Summary

• Protein general information: Q6MZZ7  
  • Name: Calpain 13 (EC 3.4.22. ) (Calcium activated neutral proteinase 13) (CANP 13)
  • Length: 669  
  • Mass: 76696
  • Tissue specificity: Weakly expressed in lung and testis. Weakly or not expressed in other tissues. {ECO
• Sequence:

  MAYYQEPSVETSIIKFKDQDFTTLRDHCLSMGRTFKDETFPAADSSIGQKLLQEKRLSNVIWKRPQDLPGGPPHF
  ILDDISRFDIQQGGAADCWFLAALGSLTQNPQYRQKILMVQSFSHQYAGIFRFRFWQCGQWVEVVIDDRLPVQGD
  KCLFVRPRHQNQEFWPCLLEKAYAKLLGSYSDLHYGFLEDALVDLTGGVITNIHLHSSPVDLVKAVKTATKAGSL
  ITCATPSGPTDTAQAMENGLVSLHAYTVTGAEQIQYRRGWEEIISLWNPWGWGEAEWRGRWSDGSQEWEETCDPR
  KSQLHKKREDGEFWMSCQDFQQKFIAMFICSEIPITLDHGNTLHEGWSQIMFRKQVILGNTAGGPRNDAQFNFSV
  QEPMEGTNVVVCVTVAVTPSNLKAEDAKFPLDFQVILAGSQRFREKFPPVFFSSFRNTVQSSNNKFRRNFTMTYH
  LSPGNYVVVAQTRRKSAEFLLRIFLKMPDSDRHLSSHFNLRMKGSPSEHGSQQSIFNRYAQQRLDIDATQLQGLL
  NQELLTGPPGDMFSLDECRSLVALMELKVNGRLDQEEFARLWKRLVHYQHVFQKVQTSPGVLLSSDLWKAIENTD
  FLRGIFISRELLHLVTLRYSDSVGRVSFPSLVCFLMRLEAMAKTFRNLSKDGKGLYLTEMEWMSLVMYN

• Structural information:
  • Protein Domains: (34..33-)
    (/note="Calpain-catalytic)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00239-)
    (538..57-)
    (/note="EF-hand-1)
    (636..66-)
    (/note="EF-hand-2")
  • Interpro: IPR022684  IPR022682  IPR036213  IPR029544  IPR011992   IPR038765  IPR001300  
  • Prosite: PS50203
  • CDD: cd00044
  • PDB: 2I7A
  • PDBsum: 2I7A
  • STRING: ENSP00000295055
• Other Databases: GeneCards:  CAPN13  Malacards:  CAPN13

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004198	calcium-dependent cysteine-type endopeptidase activity	IBA	molecular function
GO:0005737	cytoplasm	IBA	cellular component
GO:0006508	proteolysis	IBA	biological process
GO:0005509	calcium ion binding	IEA	molecular function
GO:0006508	proteolysis	IEA	biological process
GO:0004198	calcium-dependent cysteine-type endopeptidase activity	IEA	molecular function
GO:0006508	proteolysis	IEA	biological process
GO:0016787	hydrolase activity	IEA	molecular function
GO:0008233	peptidase activity	IEA	molecular function
GO:0008234	cysteine-type peptidase activity	IEA	molecular function

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)