• Gene id: 92283

Gene Summary

• Gene Symbol: ZNF461   Gene   UCSC   Ensembl
• Aliases: GIOT-1, GIOT1, HZF28
• Gene name: zinc finger protein 461
• Alternate names: zinc finger protein 461, gonadotropin-inducible ovary transcription repressor 1, zinc finger protein 28,
• Gene location: 19q13.12 (36666836: 36636617)     Exons: 9     NC_000019.10
• OMIM: 608640

Protein Summary

• Protein general information: Q8TAF7  
  • Name: Zinc finger protein 461 (Gonadotropin inducible ovary transcription repressor 1) (GIOT 1)
  • Length: 563  
  • Mass: 66214
  • Tissue specificity: Widely expressed, with highest levels in liver, kidney, pancreas, thymus, and small intestine. {ECO
• Sequence:

  MAHELVMFRDVAIDVSQEEWECLNPAQRNLYKEVMLENYSNLVSLGLSVSKPAVISSLEQGKEPWMVVREETGRW
  CPGTWKTWGFHNNFLDNNEATDINADLASRDEPQKLSPKRDIYETELSQWVNMEEFKSHSPERSIFSAIWEGNCH
  FEQHQGQEEGYFRQLMINHENMPIFSQHTLLTQEFYDREKISECKKCRKIFSYHLFFSHHKRTHSKELSECKECT
  EIVNTPCLFKQQTIQNGDKCNECKECWKAFVHCSQLKHLRIHNGEKRYECNECGKAFNYGSELTLHQRIHTGEKP
  YECKECGKAFRQRSQLTQHQRLHTGEKPYECKQCGKAFIRGFQLTEHLRLHTGEKPYECKECGKTFRHRSHLTIH
  QRIHTGEKPYECRECGKAFSYHSSFSHHQKIHSGKKPYECHECGKAFCDGLQLTLHQRIHTGEKPYECKECGKTF
  RQCSHLKRHQRIHTGEKPHECMICGKAFRLHSHLIQHQRIHTGEKPYECKECGKAFSYHSSFSHHQRIHSGKKPY
  QCGKAFNHRLQLNLHQTLHTGEKPVRFPLLPPHPSLAS

• Structural information:
  • Protein Domains: (6..7-)
    (/note="KRAB-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00119"-)
  • Interpro: IPR001909  IPR036051  IPR036236  IPR013087  
  • Prosite: PS50805 PS00028 PS50157
  • CDD: cd07765
  • STRING: ENSP00000467931
• Other Databases: GeneCards:  ZNF461  Malacards:  ZNF461

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0003676	nucleic acid binding	IEA	molecular function
GO:0006355	regulation of transcription, DNA-templated	IEA	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0003677	DNA binding	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005634	nucleus	IEA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa05168	Herpes simplex virus 1 infection

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)