• Gene id: 91978

Gene Summary

• Gene Symbol: TPGS1   Gene   UCSC   Ensembl
• Aliases: C19orf20, GTRGEO22, PGs1
• Gene name: tubulin polyglutamylase complex subunit 1
• Alternate names: tubulin polyglutamylase complex subunit 1, gene trap ROSA b-geo 22,
• Gene location: 19p13.3 (22644619: 22647897)     Exons: 6     NC_000022.11

Protein Summary

• Protein general information: Q6ZTW0  
  • Name: Tubulin polyglutamylase complex subunit 1 (PGs1)
  • Length: 290  
  • Mass: 31275
• Sequence:

  MAAVEKRRQAVPPPAGFTDSGRQSVSRAAGAAESEEDFLRQVGVTEMLRAALLKVLEARPEEPIAFLAHYFENMG
  LRSPVNGGAGEPPGQLLLQQQRLGRALWHLRLAHHSQRAAFNNNVSVAYECLSAGGRRKRPGLDGRTYSELLRRI
  CRDGQAPEEVVAPLLRKVQCRDHEAVPLSVFRAGTLTCFVLLEFVARAGALFQLLEDSAAAVADRRVGQAVLDTL
  EGALQASDAAAPARFLEAGSRLGPDSLALALDRAVGGRRPSAPMTREEFLERAAALFIAKVKPVG

• Structural information:
  • Interpro: IPR039235  
  • STRING: ENSP00000352265
• Other Databases: GeneCards:  TPGS1  Malacards:  TPGS1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005813	centrosome	IDA	cellular component
GO:0018095	protein polyglutamylation	IEA	biological process
GO:0042995	cell projection	IEA	cellular component
GO:0007283	spermatogenesis	IEA	biological process
GO:0030154	cell differentiation	IEA	biological process
GO:0005929	cilium	IEA	cellular component
GO:0007275	multicellular organism development	IEA	biological process
GO:0031514	motile cilium	IEA	cellular component
GO:0005856	cytoskeleton	IEA	cellular component
GO:0005874	microtubule	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0030534	adult behavior	IEA	biological process
GO:0051648	vesicle localization	IEA	biological process
GO:0007268	chemical synaptic transmission	IEA	biological process
GO:0007288	sperm axoneme assembly	IEA	biological process
GO:0008017	microtubule binding	IEA	molecular function
GO:0015631	tubulin binding	IEA	molecular function
GO:0018095	protein polyglutamylation	IEA	biological process
GO:0070740	tubulin-glutamic acid ligase activity	IEA	molecular function
GO:0030425	dendrite	IEA	cellular component
GO:0030424	axon	IEA	cellular component
GO:0005815	microtubule organizing center	IEA	cellular component
GO:0045202	synapse	IEA	cellular component

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq