• Gene id: 91947

Gene Summary

• Gene Symbol: ARRDC4   Gene   UCSC   Ensembl
• Gene name: arrestin domain containing 4
• Alternate names: arrestin domain-containing protein 4,
• Gene location: 15q26.2 (57191499: 57222845)     Exons: 4     NC_000019.10

Protein Summary

• Protein general information: Q8NCT1  
  • Name: Arrestin domain containing protein 4
  • Length: 418  
  • Mass: 45479
• Sequence:

  MGGEAGCAAAVGAEGRVKSLGLVFEDERKGCYSSGETVAGHVLLEASEPVALRALRLEAQGRATAAWGPSTCPRA
  SASTAALAVFSEVEYLNVRLSLREPPAGEGIILLQPGKHEFPFRFQLPSEPLVTSFTGKYGSIQYCVRAVLERPK
  VPDQSVKRELQVVSHVDVNTPALLTPVLKTQEKMVGCWFFTSGPVSLSAKIERKGYCNGEAIPIYAEIENCSSRL
  IVPKAAIFQTQTYLASGKTKTIRHMVANVRGNHIASGSTDTWNGKTLKIPPVTPSILDCCIIRVDYSLAVYIHIP
  GAKKLMLELPLVIGTIPYNGFGSRNSSIASQFSMDMSWLTLTLPEQPEAPPNYADVVSEEEFSRHIPPYPQPPNC
  EGEVCCPVFACIQEFRFQPPPLYSEVDPHPSDVEESQPVSFIL

• Structural information:
  • Interpro: IPR011021  IPR014752  IPR011022  IPR014756  
  • STRING: ENSP00000268042
• Other Databases: GeneCards:  ARRDC4  Malacards:  ARRDC4

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0015031	protein transport	IBA	biological process
GO:0005886	plasma membrane	IBA	cellular component
GO:0005737	cytoplasm	IBA	cellular component
GO:1990756	ubiquitin ligase-substrate adaptor activity	IBA	molecular function
GO:1903561	extracellular vesicle	ISS	cellular component
GO:1990756	ubiquitin ligase-substrate adaptor activity	ISS	molecular function
GO:0016567	protein ubiquitination	ISS	biological process
GO:0015031	protein transport	ISS	biological process
GO:0140112	extracellular vesicle biogenesis	ISS	biological process
GO:0005768	endosome	IEA	cellular component
GO:0031410	cytoplasmic vesicle	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0005768	endosome	IDA	cellular component
GO:0005886	plasma membrane	IDA	cellular component
GO:0051443	positive regulation of ubiquitin-protein transferase activity	IPI	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005886	plasma membrane	IEA	cellular component
GO:0015031	protein transport	IEA	biological process
GO:0016567	protein ubiquitination	IEA	biological process
GO:0140112	extracellular vesicle biogenesis	IEA	biological process
GO:1903561	extracellular vesicle	IEA	cellular component
GO:1990756	ubiquitin ligase-substrate adaptor activity	IEA	molecular function
GO:0005769	early endosome	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0005886	plasma membrane	IDA	cellular component
GO:0043231	intracellular membrane-bounded organelle	IDA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881