• Gene id: 91807

Gene Summary

• Gene Symbol: MYLK3   Gene   UCSC   Ensembl
• Aliases: MLCK, MLCK2, caMLCK
• Gene name: myosin light chain kinase 3
• Alternate names: myosin light chain kinase 3, MLC kinase, cardiac-MLCK, cardiac-MyBP-C associated Ca/CaM kinase, putative myosin light chain kinase 3,
• Gene location: 16q11.2 (46763245: 46702281)     Exons: 14     NC_000016.10
• Gene summary(Entrez): Phosphorylation of cardiac myosin heavy chains (see MYH7B, MIM 609928) and light chains (see MYL2, MIM 160781) by a kinase, such as MYLK3, potentiates the force and rate of cross-bridge recruitment in cardiac myocytes (Chan et al., 2008 [PubMed 18202317])
• OMIM: 604970

Protein Summary

• Protein general information: Q32MK0  
  • Name: Myosin light chain kinase 3 (EC 2.7.11.18) (Cardiac MyBP C associated Ca/CaM kinase) (Cardiac MLCK)
  • Length: 819  
  • Mass: 88393
  • Tissue specificity: Restricted to heart. {ECO
• Sequence:

  MSGTSKESLGHGGLPGLGKTCLTTMDTKLNMLNEKVDQLLHFQEDVTEKLQSMCRDMGHLERGLHRLEASRAPGP
  GGADGVPHIDTQAGWPEVLELVRAMQQDAAQHGARLEALFRMVAAVDRAIALVGATFQKSKVADFLMQGRVPWRR
  GSPGDSPEENKERVEEEGGKPKHVLSTSGVQSDAREPGEESQKADVLEGTAERLPPIRASGLGADPAQAVVSPGQ
  GDGVPGPAQAFPGHLPLPTKVEAKAPETPSENLRTGLELAPAPGRVNVVSPSLEVAPGAGQGASSSRPDPEPLEE
  GTRLTPGPGPQCPGPPGLPAQARATHSGGETPPRISIHIQEMDTPGEMLMTGRGSLGPTLTTEAPAAAQPGKQGP
  PGTGRCLQAPGTEPGEQTPEGARELSPLQESSSPGGVKAEEEQRAGAEPGTRPSLARSDDNDHEVGALGLQQGKS
  PGAGNPEPEQDCAARAPVRAEAVRRMPPGAEAGSVVLDDSPAPPAPFEHRVVSVKETSISAGYEVCQHEVLGGGR
  FGQVHRCTEKSTGLPLAAKIIKVKSAKDREDVKNEINIMNQLSHVNLIQLYDAFESKHSCTLVMEYVDGGELFDR
  ITDEKYHLTELDVVLFTRQICEGVHYLHQHYILHLDLKPENILCVNQTGHQIKIIDFGLARRYKPREKLKVNFGT
  PEFLAPEVVNYEFVSFPTDMWSVGVITYMLLSGLSPFLGETDAETMNFIVNCSWDFDADTFEGLSEEAKDFVSRL
  LVKEKSCRMSATQCLKHEWLNNLPAKASRSKTRLKSQLLLQKYIAQRKWKKHFYVVTAANRLRKFPTSP

• Structural information:
  • Protein Domains: (515..77-)
    (/note="Protein-kinase)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"-)
  • Interpro: IPR011009  IPR000719  IPR017441  IPR008271  
  • Prosite: PS00107 PS50011 PS00108
  • STRING: ENSP00000378288
• Other Databases: GeneCards:  MYLK3  Malacards:  MYLK3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004687	myosin light chain kinase activity	IBA	molecular function
GO:0015629	actin cytoskeleton	IBA	colocalizes with
GO:0055003	cardiac myofibril assembly	IBA	biological process
GO:0005737	cytoplasm	IBA	cellular component
GO:0045214	sarcomere organization	IBA	biological process
GO:0004672	protein kinase activity	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0006468	protein phosphorylation	IEA	biological process
GO:0016740	transferase activity	IEA	molecular function
GO:0016301	kinase activity	IEA	molecular function
GO:0000166	nucleotide binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0016310	phosphorylation	IEA	biological process
GO:0005524	ATP binding	IEA	molecular function
GO:0004674	protein serine/threonine kinase activity	IEA	molecular function
GO:0004687	myosin light chain kinase activity	IEA	molecular function
GO:0015629	actin cytoskeleton	IEA	cellular component
GO:0004687	myosin light chain kinase activity	IEA	molecular function
GO:0004683	calmodulin-dependent protein kinase activity	IEA	molecular function
GO:0055003	cardiac myofibril assembly	IEA	biological process
GO:0005829	cytosol	IEA	cellular component
GO:0004687	myosin light chain kinase activity	IEA	molecular function
GO:0004683	calmodulin-dependent protein kinase activity	IEA	molecular function
GO:0045214	sarcomere organization	IEA	biological process
GO:0006468	protein phosphorylation	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0060298	positive regulation of sarcomere organization	IEA	biological process
GO:0048769	sarcomerogenesis	IEA	biological process
GO:0045214	sarcomere organization	IEA	biological process
GO:0006468	protein phosphorylation	IEA	biological process
GO:0004683	calmodulin-dependent protein kinase activity	ISS	molecular function
GO:0004687	myosin light chain kinase activity	ISS	molecular function
GO:0002528	regulation of vascular permeability involved in acute inflammatory response	IMP	biological process
GO:0005829	cytosol	ISS	cellular component
GO:0055003	cardiac myofibril assembly	ISS	biological process
GO:0005737	cytoplasm	ISS	cellular component
GO:0006468	protein phosphorylation	ISS	biological process
GO:0045214	sarcomere organization	ISS	biological process
GO:0048769	sarcomerogenesis	ISS	biological process
GO:0060298	positive regulation of sarcomere organization	ISS	biological process
GO:0071347	cellular response to interleukin-1	IMP	biological process
GO:0005737	cytoplasm	IEA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa04810	Regulation of actin cytoskeleton
hsa04020	Calcium signaling pathway
hsa04510	Focal adhesion
hsa04022	cGMP-PKG signaling pathway
hsa04921	Oxytocin signaling pathway
hsa04371	Apelin signaling pathway
hsa04270	Vascular smooth muscle contraction
hsa04611	Platelet activation
hsa04971	Gastric acid secretion

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq