• Gene id: 9175

Gene Summary

• Gene Symbol: MAP3K13   Gene   UCSC   Ensembl
• Aliases: LZK, MEKK13, MLK
• Gene name: mitogen-activated protein kinase kinase kinase 13
• Alternate names: mitogen-activated protein kinase kinase kinase 13, leucine zipper-bearing kinase, mixed lineage kinase,
• Gene location: 3q27.2 (185282937: 185489093)     Exons: 11     NC_000003.12
• Gene summary(Entrez): The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activ
• OMIM: 604915

Protein Summary

• Protein general information: O43283  
  • Name: Mitogen activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Leucine zipper bearing kinase) (Mixed lineage kinase) (MLK)
  • Length: 966  
  • Mass: 108296
  • Tissue specificity: Expressed in the adult brain, liver, placenta and pancreas, with expression strongest in the pancreas. {ECO
• Sequence:

  MANFQEHLSCSSSPHLPFSESKTFNGLQDELTAMGNHPSPKLLEDQQEKGMVRTELIESVHSPVTTTVLTSVSED
  SRDQFENSVLQLREHDESETAVSQGNSNTVDGESTSGTEDIKIQFSRSGSGSGGFLEGLFGCLRPVWNIIGKAYS
  TDYKLQQQDTWEVPFEEISELQWLGSGAQGAVFLGKFRAEEVAIKKVREQNETDIKHLRKLKHPNIIAFKGVCTQ
  APCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGT
  SKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVP
  STCPDGFKILMKQTWQSKPRNRPSFRQTLMHLDIASADVLATPQETYFKSQAEWREEVKKHFEKIKSEGTCIHRL
  DEELIRRRREELRHALDIREHYERKLERANNLYMELSAIMLQLEMREKELIKREQAVEKKYPGTYKRHPVRPIIH
  PNAMEKLMKRKGVPHKSGMQTKRPDLLRSEGIPTTEVAPTASPLSGSPKMSTSSSKSRYRSKPRHRRGNSRGSHS
  DFAAILKNQPAQENSPHPTYLHQAQSQYPSLHHHNSLQQQYQQPPPAMSQSHHPRLNMHGQDIATCANNLRYFGP
  AAALRSPLSNHAQRQLPGSSPDLISTAMAADCWRSSEPDKGQAGPWGCCQADAYDPCLQCRPEQYGSLDIPSAEP
  VGRSPDLSKSPAHNPLLENAQSSEKTEENEFSGCRSESSLGTSHLGTPPALPRKTRPLQKSGDDSSEEEEGEVDS
  EVEFPRRQRPHRCISSCQSYSTFSSENFSVSDGEEGNTSDHSNSPDELADKLEDRLAEKLDDLLSQTPEIPIDIS
  SHSDGLSDKECAVRRVKTQMSLGKLCVEERGYENPMQFEESDCDSSDGECSDATVRTNKHYSSATW

• Structural information:
  • Protein Domains: (168..40-)
    (/note="Protein-kinase)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"-)
  • Interpro: IPR011009  IPR017419  IPR027258  IPR000719  IPR001245   IPR008271  
  • Prosite: PS50011 PS00108
  • STRING: ENSP00000265026
• Other Databases: GeneCards:  MAP3K13  Malacards:  MAP3K13

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004706	JUN kinase kinase kinase activity	ISS	molecular function
GO:0007257	activation of JUN kinase activity	ISS	biological process
GO:0007256	activation of JNKK activity	ISS	biological process
GO:0150012	positive regulation of neuron projection arborization	ISS	biological process
GO:1905492	positive regulation of branching morphogenesis of a nerve	ISS	biological process
GO:0014042	positive regulation of neuron maturation	ISS	biological process
GO:0018105	peptidyl-serine phosphorylation	ISS	biological process
GO:0045773	positive regulation of axon extension	ISS	biological process
GO:0051092	positive regulation of NF-kappaB transcription factor activity	IBA	biological process
GO:0007257	activation of JUN kinase activity	IBA	biological process
GO:0004709	MAP kinase kinase kinase activity	IBA	molecular function
GO:0004706	JUN kinase kinase kinase activity	IBA	molecular function
GO:0004672	protein kinase activity	IBA	molecular function
GO:0004709	MAP kinase kinase kinase activity	IEA	molecular function
GO:0007254	JNK cascade	IEA	biological process
GO:0042803	protein homodimerization activity	IEA	molecular function
GO:0046777	protein autophosphorylation	IEA	biological process
GO:0051092	positive regulation of NF-kappaB transcription factor activity	IEA	biological process
GO:0000186	activation of MAPKK activity	IEA	biological process
GO:0004672	protein kinase activity	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0006468	protein phosphorylation	IEA	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0016301	kinase activity	IEA	molecular function
GO:0000166	nucleotide binding	IEA	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0005524	ATP binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0016310	phosphorylation	IEA	biological process
GO:0004674	protein serine/threonine kinase activity	IEA	molecular function
GO:0004709	MAP kinase kinase kinase activity	IEA	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0007256	activation of JNKK activity	IEA	biological process
GO:0007257	activation of JUN kinase activity	IEA	biological process
GO:0014042	positive regulation of neuron maturation	IEA	biological process
GO:0018105	peptidyl-serine phosphorylation	IEA	biological process
GO:0045773	positive regulation of axon extension	IEA	biological process
GO:0150012	positive regulation of neuron projection arborization	IEA	biological process
GO:0004706	JUN kinase kinase kinase activity	IEA	molecular function
GO:1905492	positive regulation of branching morphogenesis of a nerve	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0051092	positive regulation of NF-kappaB transcription factor activity	IDA	biological process
GO:0042803	protein homodimerization activity	IDA	molecular function
GO:0007254	JNK cascade	IDA	biological process
GO:0006468	protein phosphorylation	IDA	biological process
GO:0004674	protein serine/threonine kinase activity	IDA	molecular function
GO:0000186	activation of MAPKK activity	IDA	biological process
GO:0046777	protein autophosphorylation	IDA	biological process
GO:0007254	JNK cascade	IDA	biological process
GO:0004709	MAP kinase kinase kinase activity	IDA	molecular function
GO:0016020	membrane	IDA	cellular component
GO:0106137	IkappaB kinase complex binding	IDA	molecular function
GO:0006468	protein phosphorylation	IDA	biological process
GO:0019901	protein kinase binding	ISS	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0019899	enzyme binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function

KEGG pathways

Pathway id	Pathway name
hsa04010	MAPK signaling pathway

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R