• Gene id: 91703

Gene Summary

• Gene Symbol: ACY3   Gene   UCSC   Ensembl
• Aliases: ACY-3, HCBP1
• Gene name: aminoacylase 3
• Alternate names: N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming), HCV core-binding protein 1, acylase III, aspartoacylase (aminoacylase) 3, aspartoacylase (aminocyclase) 3, aspartoacylase-2, hepatitis C virus core-binding protein 1,
• Gene location: 11q13.2 (67650828: 67642550)     Exons: 9     NC_000011.10
• OMIM: 610920

Protein Summary

• Protein general information: Q96HD9  
  • Name: N acyl aromatic L amino acid amidohydrolase (carboxylate forming) (EC 3.5.1.114) (Acylase III) (Aminoacylase 3) (ACY 3) (Aspartoacylase 2) (Hepatitis C virus core binding protein 1) (HCBP1) (HCV core binding protein 1)
  • Length: 319  
  • Mass: 35241
• Sequence:

  MCSLPVPREPLRRVAVTGGTHGNEMSGVYLARHWLHAPAELQRASFSAVPVLANPAATSGCRRYVDHDLNRTFTS
  SFLNSRPTPDDPYEVTRARELNQLLGPKASGQAFDFVLDLHNTTANMGTCLIAKSSHEVFAMHLCRHLQLQYPEL
  SCQVFLYQRSGEESYNLDSVAKNGLGLELGPQPQGVLRADIFSRMRTLVATVLDFIELFNQGTAFPAFEMEAYRP
  VGVVDFPRTEAGHLAGTVHPQLQDRDFQPLQPGAPIFQMFSGEDLLYEGESTVYPVFINEAAYYEKGVAFVQTEK
  FTFTVPAMPALTPAPSPAS

• Structural information:
  • Interpro: IPR016708  IPR007036  
  • STRING: ENSP00000255082
• Other Databases: GeneCards:  ACY3  Malacards:  ACY3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004046	aminoacylase activity	IBA	molecular function
GO:0005829	cytosol	IBA	cellular component
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	IBA	molecular function
GO:0016788	hydrolase activity, acting on ester bonds	IEA	molecular function
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0016032	viral process	IEA	biological process
GO:0005886	plasma membrane	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0006805	xenobiotic metabolic process	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0042802	identical protein binding	IEA	molecular function
GO:0016324	apical plasma membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0004046	aminoacylase activity	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0016324	apical plasma membrane	IEA	cellular component
GO:0008150	biological_process	ND	biological process
GO:0003674	molecular_function	ND	molecular function
GO:0070062	extracellular exosome	HDA	cellular component
GO:0004046	aminoacylase activity	ISS	molecular function

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq