• Gene id: 9147

Gene Summary

• Gene Symbol: NEMF   Gene   UCSC   Ensembl
• Aliases: NY-CO-1, SDCCAG1
• Gene name: nuclear export mediator factor
• Alternate names: nuclear export mediator factor NEMF, antigen NY-CO-1, serologically defined colon cancer antigen 1,
• Gene location: 14q21.3 (49853202: 49782082)     Exons: 37     NC_000014.9
• Gene summary(Entrez): This gene encodes a component of the ribosome quality control complex. The encoded protein facilitates the recognition and ubiquitination of stalled 60S subunits by the ubiquitin ligase listerin. A similar protein in fly functions as a tumor suppressor. [
• OMIM: 608378

Protein Summary

• Protein general information: O60524  
  • Name: Nuclear export mediator factor NEMF (Antigen NY CO 1) (Serologically defined colon cancer antigen 1)
  • Length: 1076  
  • Mass: 122954
  • Tissue specificity: Expressed in brain, heart, liver, lung, spleen, and skeletal muscle. Also expressed at lower levels in stomach and testis. {ECO
• Sequence:

  MKSRFSTIDLRAVLAELNASLLGMRVNNVYDVDNKTYLIRLQKPDFKATLLLESGIRIHTTEFEWPKNMMPSSFA
  MKCRKHLKSRRLVSAKQLGVDRIVDFQFGSDEAAYHLIIELYDRGNIVLTDYEYVILNILRFRTDEADDVKFAVR
  ERYPLDHARAAEPLLTLERLTEIVASAPKGELLKRVLNPLLPYGPALIEHCLLENGFSGNVKVDEKLETKDIEKV
  LVSLQKAEDYMKTTSNFSGKGYIIQKREIKPSLEADKPVEDILTYEEFHPFLFSQHSQCPYIEFESFDKAVDEFY
  SKIEGQKIDLKALQQEKQALKKLDNVRKDHENRLEALQQAQEIDKLKGELIEMNLQIVDRAIQVVRSALANQIDW
  TEIGLIVKEAQAQGDPVASAIKELKLQTNHVTMLLRNPYLLSEEEDDDVDGDVNVEKNETEPPKGKKKKQKNKQL
  QKPQKNKPLLVDVDLSLSAYANAKKYYDHKRYAAKKTQKTVEAAEKAFKSAEKKTKQTLKEVQTVTSIQKARKVY
  WFEKFLWFISSENYLIIGGRDQQQNEIIVKRYLTPGDIYVHADLHGATSCVIKNPTGEPIPPRTLTEAGTMALCY
  SAAWDARVITSAWWVYHHQVSKTAPTGEYLTTGSFMIRGKKNFLPPSYLMMGFSFLFKVDESCVWRHQGERKVRV
  QDEDMETLASCTSELISEEMEQLDGGDTSSDEDKEEHETPVEVELMTQVDQEDITLQSGRDELNEELIQEESSED
  EGEYEEVRKDQDSVGEMKDEGEETLNYPDTTIDLSHLQPQRSIQKLASKEESSNSSDSKSQSRRHLSAKERREMK
  KKKLPSDSGDLEALEGKDKEKESTVHIETHQNTSKNVAAVQPMKRGQKSKMKKMKEKYKDQDEEDRELIMKLLGS
  AGSNKEEKGKKGKKGKTKDEPVKKQPQKPRGGQRVSDNIKKETPFLEVITHELQDFAVDDPHDDKEEQDLDQQGN
  EENLFDSLTGQPHPEDVLLFAIPICAPYTTMTNYKYKVKLTPGVQKKGKAAKTALNSFMHSKEATAREKDLFRSV
  KDTDLSRNIPGKVKVSAPNLLNVKRK

• Structural information:
  • Interpro: IPR021846  IPR008532  
  • PDB: 3J92
  • PDBsum: 3J92
  • STRING: ENSP00000298310
• Other Databases: GeneCards:  NEMF  Malacards:  NEMF

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0000049	tRNA binding	IBA	molecular function
GO:0072344	rescue of stalled ribosome	IBA	biological process
GO:1990112	RQC complex	IBA	cellular component
GO:0043023	ribosomal large subunit binding	IBA	molecular function
GO:1990116	ribosome-associated ubiquitin-dependent protein catabolic process	IBA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0051168	nuclear export	IMP	biological process

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq