• Gene id: 91355

Gene Summary

• Gene Symbol: LRP5L   Gene   UCSC   Ensembl
• Gene name: LDL receptor related protein 5 like
• Alternate names: low-density lipoprotein receptor-related protein 5-like protein, LRP-5-like, low density lipoprotein receptor-related protein 5-like,
• Gene location: 22q11.23 (25405409: 25351417)     Exons: 9     NC_000022.11
• OMIM: 617997

Protein Summary

• Protein general information: A4QPB2  
  • Name: Low density lipoprotein receptor related protein 5 like protein (LRP 5 like)
  • Length: 252  
  • Mass: 28483
• Sequence:

  MEGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCLNSTSHKILVSED
  MDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEAISV
  DETKRQTLLKDKLPHIFRFTLLGDFIYWTAWQHHSIKRVHKVKANRDVIIDQLPDLMGLKAVNVDKVVGTNPHAD
  RNGGAATCASSRPTQPGLAAPSRAWNC

• Structural information:
  • Interpro: IPR011042  IPR000033  
  • Prosite: PS51120
  • STRING: ENSP00000482378
• Other Databases: GeneCards:  LRP5L  Malacards:  LRP5L

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0002076	osteoblast development	IBA	biological process
GO:0005886	plasma membrane	IBA	cellular component
GO:0015026	coreceptor activity	IBA	molecular function
GO:0017147	Wnt-protein binding	IBA	molecular function
GO:0045944	positive regulation of transcription by RNA polymerase II	IBA	biological process
GO:0046849	bone remodeling	IBA	biological process
GO:0060070	canonical Wnt signaling pathway	IBA	biological process
GO:0060349	bone morphogenesis	IBA	biological process
GO:0060444	branching involved in mammary gland duct morphogenesis	IBA	biological process
GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus	IBA	biological process
GO:0061304	retinal blood vessel morphogenesis	IBA	biological process
GO:0001702	gastrulation with mouth forming second	IBA	biological process
GO:0009952	anterior/posterior pattern specification	IBA	biological process
GO:0042632	cholesterol homeostasis	IBA	biological process
GO:0042813	Wnt-activated receptor activity	IBA	molecular function
GO:0043235	receptor complex	IBA	cellular component
GO:0048539	bone marrow development	IBA	biological process
GO:0060612	adipose tissue development	IBA	biological process

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq