• Gene id: 9097

Gene Summary

• Gene Symbol: USP14   Gene   UCSC   Ensembl
• Aliases: TGT
• Gene name: ubiquitin specific peptidase 14
• Alternate names: ubiquitin carboxyl-terminal hydrolase 14, deubiquitinating enzyme 14, tRNA-guanine transglycosylase, 60-kD subunit, ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase), ubiquitin specific protease 14 (tRNA-guanine transglycosylase), ubiquitin thioe,
• Gene location: 18p11.32 (158556: 214628)     Exons: 16     NC_000018.10
• Gene summary(Entrez): This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused prec
• OMIM: 607274

Protein Summary

• Protein general information: P54578  
  • Name: Ubiquitin carboxyl terminal hydrolase 14 (EC 3.4.19.12) (Deubiquitinating enzyme 14) (Ubiquitin thioesterase 14) (Ubiquitin specific processing protease 14)
  • Length: 494  
  • Mass: 56069
• Sequence:

  MPLYSVTVKWGKEKFEGVELNTDEPPMVFKAQLFALTGVQPARQKVMVKGGTLKDDDWGNIKIKNGMTLLMMGSA
  DALPEEPSAKTVFVEDMTEEQLASAMELPCGLTNLGNTCYMNATVQCIRSVPELKDALKRYAGALRASGEMASAQ
  YITAALRDLFDSMDKTSSSIPPIILLQFLHMAFPQFAEKGEQGQYLQQDANECWIQMMRVLQQKLEAIEDDSVKE
  TDSSSASAATPSKKKSLIDQFFGVEFETTMKCTESEEEEVTKGKENQLQLSCFINQEVKYLFTGLKLRLQEEITK
  QSPTLQRNALYIKSSKISRLPAYLTIQMVRFFYKEKESVNAKVLKDVKFPLMLDMYELCTPELQEKMVSFRSKFK
  DLEDKKVNQQPNTSDKKSSPQKEVKYEPFSFADDIGSNNCGYYDLQAVLTHQGRSSSSGHYVSWVKRKQDEWIKF
  DDDKVSIVTPEDILRLSGGGDWHIAYVLLYGPRRVEIMEEESEQ

• Structural information:
  • Protein Domains: (4..8-)
    (/note="Ubiquitin-like-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00214-)
    (105..48-)
    (/note="USP"-)
  • Interpro: IPR038765  IPR001394  IPR000626  IPR029071  IPR019954   IPR018200  IPR028889  
  • Prosite: PS00299 PS50053 PS00972 PS00973 PS50235
  • PDB: 2AYN 2AYO 5GJQ 6IIK 6IIL 6IIM 6IIN
  • PDBsum: 2AYN 2AYO 5GJQ 6IIK 6IIL 6IIM 6IIN
  • STRING: ENSP00000261601
• Other Databases: GeneCards:  USP14  Malacards:  USP14

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:1903070	negative regulation of ER-associated ubiquitin-dependent protein catabolic process	IMP	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005634	nucleus	IBA	cellular component
GO:0031410	cytoplasmic vesicle	IDA	cellular component
GO:0070628	proteasome binding	IDA	molecular function
GO:0009986	cell surface	IDA	cellular component
GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	IDA	molecular function
GO:0004866	endopeptidase inhibitor activity	IMP	molecular function
GO:0061136	regulation of proteasomal protein catabolic process	IMP	biological process
GO:0050920	regulation of chemotaxis	IMP	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0006511	ubiquitin-dependent protein catabolic process	IEA	biological process
GO:0016579	protein deubiquitination	IEA	biological process
GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	IEA	molecular function
GO:0006508	proteolysis	IEA	biological process
GO:0002376	immune system process	IEA	biological process
GO:0045087	innate immune response	IEA	biological process
GO:0008233	peptidase activity	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0008234	cysteine-type peptidase activity	IEA	molecular function
GO:0005886	plasma membrane	IEA	cellular component
GO:0000502	proteasome complex	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0004197	cysteine-type endopeptidase activity	TAS	molecular function
GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	IEA	molecular function
GO:0004843	thiol-dependent ubiquitin-specific protease activity	IDA	molecular function
GO:0016579	protein deubiquitination	IDA	biological process
GO:0016579	protein deubiquitination	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0045202	synapse	IEA	cellular component
GO:0007268	chemical synaptic transmission	IEA	biological process
GO:0005886	plasma membrane	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0010951	negative regulation of endopeptidase activity	IEA	biological process
GO:0070062	extracellular exosome	HDA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881