• Gene id: 9037

Gene Summary

• Gene Symbol: SEMA5A   Gene   UCSC   Ensembl
• Aliases: SEMAF, semF
• Gene name: semaphorin 5A
• Alternate names: semaphorin-5A, sema F, sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A, semaphorin F,
• Gene location: 5p15.31 (9546120: 9035029)     Exons: 28     NC_000005.10
• Gene summary(Entrez): This gene belongs to the semaphorin gene family that encodes membrane proteins containing a semaphorin domain and several thrombospondin type-1 repeats. Members of this family are involved in axonal guidance during neural development. This gene has been i

Protein Summary

• Protein general information: Q13591  
  • Name: Semaphorin 5A (Semaphorin F) (Sema F)
  • Length: 1074  
  • Mass: 120615
• Sequence:

  MKGTCVIAWLFSSLGLWRLAHPEAQGTTQCQRTEHPVISYKEIGPWLREFRAKNAVDFSQLTFDPGQKELVVGAR
  NYLFRLQLEDLSLIQAVEWECDEATKKACYSKGKSKEECQNYIRVLLVGGDRLFTCGTNAFTPVCTNRSLSNLTE
  IHDQISGMARCPYSPQHNSTALLTAGGELYAATAMDFPGRDPAIYRSLGILPPLRTAQYNSKWLNEPNFVSSYDI
  GNFTYFFFRENAVEHDCGKTVFSRAARVCKNDIGGRFLLEDTWTTFMKARLNCSRPGEVPFYYNELQSTFFLPEL
  DLIYGIFTTNVNSIAASAVCVFNLSAIAQAFSGPFKYQENSRSAWLPYPNPNPHFQCGTVDQGLYVNLTERNLQD
  AQKFILMHEVVQPVTTVPSFMEDNSRFSHVAVDVVQGREALVHIIYLATDYGTIKKVRVPLNQTSSSCLLEEIEL
  FPERRREPIRSLQILHSQSVLFVGLREHVVKIPLKRCQFYRTRSTCIGAQDPYCGWDVVMKKCTSLEESLSMTQW
  EQSISACPTRNLTVDGHFGVWSPWTPCTHTDGSAVGSCLCRTRSCDSPAPQCGGWQCEGPGMEIANCSRNGGWTP
  WTSWSPCSTTCGIGFQVRQRSCSNPTPRHGGRVCVGQNREERYCNEHLLCPPHMFWTGWGPWERCTAQCGGGIQA
  RRRICENGPDCAGCNVEYQSCNTNPCPELKKTTPWTPWTPVNISDNGGHYEQRFRYTCKARLADPNLLEVGRQRI
  EMRYCSSDGTSGCSTDGLSGDFLRAGRYSAHTVNGAWSAWTSWSQCSRDCSRGIRNRKRVCNNPEPKYGGMPCLG
  PSLEYQECNILPCPVDGVWSCWSPWTKCSATCGGGHYMRTRSCSNPAPAYGGDICLGLHTEEALCNTQPCPESWS
  EWSDWSECEASGVQVRARQCILLFPMGSQCSGNTTESRPCVFDSNFIPEVSVARSSSVEEKRCGEFNMFHMIAVG
  LSSSILGCLLTLLVYTYCQRYQQQSHDATVIHPVSPAPLNTSITNHINKLDKYDSVEAIKAFNKNNLILEERNKY
  FNPHLTGKTYSNAYFTDLNNYDEY

• Structural information:
  • Protein Domains: (35..48-)
    (/note="Sema-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00352-)
    (540..59-)
    1 (/note="TSP-type-1)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00210-)
    (595..65-)
    2 (/note="TSP-type-1)
    (/evidence="ECO:0000255|PROSITE-ProRule:PR-)
  • Interpro: IPR016201  IPR042821  IPR001627  IPR036352  IPR027231   IPR000884  IPR036383  IPR015943  
  • Prosite: PS51004 PS50092
  • CDD: cd11263
  • STRING: ENSP00000371936
• Other Databases: GeneCards:  SEMA5A  Malacards:  SEMA5A

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0030215	semaphorin receptor binding	IBA	molecular function
GO:0048675	axon extension	IBA	biological process
GO:0007411	axon guidance	IBA	biological process
GO:0016021	integral component of membrane	IBA	cellular component
GO:0071526	semaphorin-plexin signaling pathway	IBA	biological process
GO:0030215	semaphorin receptor binding	IEA	molecular function
GO:0030154	cell differentiation	IEA	biological process
GO:0007275	multicellular organism development	IEA	biological process
GO:0016021	integral component of membrane	IEA	cellular component
GO:0007399	nervous system development	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0007155	cell adhesion	TAS	biological process
GO:0007399	nervous system development	TAS	biological process
GO:0007267	cell-cell signaling	TAS	biological process
GO:0005886	plasma membrane	TAS	cellular component
GO:0016020	membrane	IEA	cellular component
GO:2001028	positive regulation of endothelial cell chemotaxis	ISS	biological process
GO:0045545	syndecan binding	ISS	molecular function
GO:0035373	chondroitin sulfate proteoglycan binding	ISS	molecular function
GO:0030215	semaphorin receptor binding	ISS	molecular function
GO:1990256	signal clustering	ISS	biological process
GO:0060326	cell chemotaxis	ISS	biological process
GO:0051897	positive regulation of protein kinase B signaling	ISS	biological process
GO:0043395	heparan sulfate proteoglycan binding	ISS	molecular function
GO:0007413	axonal fasciculation	ISS	biological process
GO:0007162	negative regulation of cell adhesion	ISS	biological process
GO:0001938	positive regulation of endothelial cell proliferation	ISS	biological process
GO:0021536	diencephalon development	ISS	biological process
GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis	ISS	biological process
GO:0070062	extracellular exosome	HDA	cellular component
GO:2000352	negative regulation of endothelial cell apoptotic process	ISS	biological process
GO:1990256	signal clustering	ISS	biological process
GO:0050918	positive chemotaxis	ISS	biological process
GO:0048843	negative regulation of axon extension involved in axon guidance	ISS	biological process
GO:0048842	positive regulation of axon extension involved in axon guidance	ISS	biological process
GO:0045766	positive regulation of angiogenesis	ISS	biological process
GO:0090263	positive regulation of canonical Wnt signaling pathway	ISS	biological process
GO:0030836	positive regulation of actin filament depolymerization	ISS	biological process
GO:0016020	membrane	ISS	cellular component
GO:0001938	positive regulation of endothelial cell proliferation	ISS	biological process

KEGG pathways

Pathway id	Pathway name
hsa04360	Axon guidance

Diseases

Associated diseases	References
Chromosme 5p deletion syndrome	KEGG:H00764
Chromosme 5p deletion syndrome	KEGG:H00764
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq