• Gene id: 90353

Gene Summary

• Gene Symbol: CTU1   Gene   UCSC   Ensembl
• Aliases: ATPBD3, NCS6
• Gene name: cytosolic thiouridylase subunit 1
• Alternate names: cytoplasmic tRNA 2-thiolation protein 1, ATP binding domain 3, ATP-binding domain-containing protein 3, cancer-associated gene protein, cancer-associated protein, cytoplasmic tRNA adenylyltransferase 1, cytosolic thiouridylase subunit 1 homolog,
• Gene location: 19q13.41 (51108408: 51097605)     Exons: 3     NC_000019.10

Protein Summary

• Protein general information: Q7Z7A3  
  • Name: Cytoplasmic tRNA 2 thiolation protein 1 (EC 2.7.7. ) (ATP binding domain containing protein 3) (Cancer associated gene protein) (Cytoplasmic tRNA adenylyltransferase 1)
  • Length: 348  
  • Mass: 36450
• Sequence:

  MPAPPCASCHAARAALRRPLSGQALCGACFCAAFEAEVLHTVLAGRLLPPGAVVAVGASGGKDSTVLAHVLRALA
  PRLGISLQLVAVDEGIGGYRDAALAAVRRQAARWELPLTVVAYEDLFGGWTMDAVARSTAGSGRSRSCCTFCGVL
  RRRALEEGARRVGATHIVTGHNADDMAETVLMNFLRGDAGRLARGGGLGSPGEGGALPRCRPLQFASQKEVVLYA
  HFRRLDYFSEECVYAPEAFRGHARDLLKRLEAARPSAVLDLVHSAERLALAPAARPPRPGACSRCGALASRALCQ
  ACALLDGLNRGRPRLAIGKGRRGLDEEATPGTPGDPARPPASKAVPTF

• Structural information:
  • Interpro: IPR032442  IPR000541  IPR014729  IPR011063  IPR035107  
  • DIP: 48632
  • STRING: ENSP00000390011
• Other Databases: GeneCards:  CTU1  Malacards:  CTU1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0002144	cytosolic tRNA wobble base thiouridylase complex	IBA	cellular component
GO:0000049	tRNA binding	IBA	molecular function
GO:0002143	tRNA wobble position uridine thiolation	IBA	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0000049	tRNA binding	IEA	molecular function
GO:0008033	tRNA processing	IEA	biological process
GO:0034227	tRNA thio-modification	IEA	biological process
GO:0002098	tRNA wobble uridine modification	IEA	biological process
GO:0008033	tRNA processing	IEA	biological process
GO:0000049	tRNA binding	IEA	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0003723	RNA binding	IEA	molecular function
GO:0006400	tRNA modification	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0016779	nucleotidyltransferase activity	IEA	molecular function
GO:0034227	tRNA thio-modification	IEA	biological process
GO:0032447	protein urmylation	IEA	biological process
GO:0000049	tRNA binding	IEA	molecular function
GO:0002098	tRNA wobble uridine modification	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0034227	tRNA thio-modification	NAS	biological process
GO:0002098	tRNA wobble uridine modification	NAS	biological process
GO:0005829	cytosol	ISS	cellular component

KEGG pathways

Pathway id	Pathway name
hsa04122	Sulfur relay system

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881