• Gene id: 90249

Gene Summary

• Gene Symbol: UNC5A   Gene   UCSC   Ensembl
• Aliases: UNC5H1
• Gene name: unc-5 netrin receptor A
• Alternate names: netrin receptor UNC5A, netrin receptor Unc5h1, protein unc-5 homolog 1, protein unc-5 homolog A, unc-5 homolog 1, unc-5 homolog A, unc5 (C.elegans homolog) a,
• Gene location: 5q35.2 (176810558: 176880897)     Exons: 17     NC_000005.10
• Gene summary(Entrez): UNC5A belongs to a family of netrin-1 (MIM 601614) receptors thought to mediate the chemorepulsive effect of netrin-1 on specific axons. For more information on UNC5 proteins, see UNC5C (MIM 603610).[supplied by OMIM, Apr 2004]
• OMIM: 605613

Protein Summary

• Protein general information: Q6ZN44  
  • Name: Netrin receptor UNC5A (Protein unc 5 homolog 1) (Protein unc 5 homolog A)
  • Length: 842  
  • Mass: 92932
• Sequence:

  MAVRPGLWPALLGIVLAAWLRGSGAQQSATVANPVPGANPDLLPHFLVEPEDVYIVKNKPVLLVCKAVPATQIFF
  KCNGEWVRQVDHVIERSTDGSSGLPTMEVRINVSRQQVEKVFGLEEYWCQCVAWSSSGTTKSQKAYIRIAYLRKN
  FEQEPLAKEVSLEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREHSLVVRQARLADTANYTCVAKN
  IVARRRSASAAVIVYVDGSWSPWSKWSACGLDCTHWRSRECSDPAPRNGGEECQGTDLDTRNCTSDLCVHTASGP
  EDVALYVGLIAVAVCLVLLLLVLILVYCRKKEGLDSDVADSSILTSGFQPVSIKPSKADNPHLLTIQPDLSTTTT
  TYQGSLCPRQDGPSPKFQLTNGHLLSPLGGGRHTLHHSSPTSEAEEFVSRLSTQNYFRSLPRGTSNMTYGTFNFL
  GGRLMIPNTGISLLIPPDAIPRGKIYEIYLTLHKPEDVRLPLAGCQTLLSPIVSCGPPGVLLTRPVILAMDHCGE
  PSPDSWSLRLKKQSCEGSWEDVLHLGEEAPSHLYYCQLEASACYVFTEQLGRFALVGEALSVAAAKRLKLLLFAP
  VACTSLEYNIRVYCLHDTHDALKEVVQLEKQLGGQLIQEPRVLHFKDSYHNLRLSIHDVPSSLWKSKLLVSYQEI
  PFYHIWNGTQRYLHCTFTLERVSPSTSDLACKLWVWQVEGDGQSFSINFNITKDTRFAELLALESEAGVPALVGP
  SAFKIPFLIRQKIISSLDPPCRRGADWRTLAQKLHLDSHLSFFASKPSPTAMILNLWEARHFPNGNLSQLAAAVA
  GLGQPDAGLFTVSEAEC

• Structural information:
  • Protein Domains: (44..14-)
    (/note="Ig-like-)
    (155..23-)
    (/note="Ig-like-C2-type)
    (242..29-)
    (/note="TSP-type-1)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00210-)
    (441..58-)
    (/note="ZU5-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00485-)
    (-)
  • Interpro: IPR011029  IPR000488  IPR042155  IPR007110  IPR036179   IPR013783  IPR013098  IPR003599  IPR000884  IPR036383  IPR037936  IPR033772  IPR000906  
  • Prosite: PS50835 PS50092 PS51145
  • CDD: cd08800
  • PDB: 4V2A
  • PDBsum: 4V2A
  • STRING: ENSP00000332737
• Other Databases: GeneCards:  UNC5A  Malacards:  UNC5A

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005042	netrin receptor activity	IBA	molecular function
GO:0007411	axon guidance	IBA	biological process
GO:0033564	anterior/posterior axon guidance	IBA	biological process
GO:0031175	neuron projection development	ISS	biological process
GO:0032809	neuronal cell body membrane	ISS	cellular component
GO:0032589	neuron projection membrane	ISS	cellular component
GO:0031226	intrinsic component of plasma membrane	ISS	cellular component
GO:0038007	netrin-activated signaling pathway	ISS	biological process
GO:0005042	netrin receptor activity	IEA	molecular function
GO:0007165	signal transduction	IEA	biological process
GO:0016021	integral component of membrane	IEA	cellular component
GO:0038007	netrin-activated signaling pathway	IEA	biological process
GO:0042995	cell projection	IEA	cellular component
GO:0007275	multicellular organism development	IEA	biological process
GO:0006915	apoptotic process	IEA	biological process
GO:0005886	plasma membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0007411	axon guidance	TAS	biological process
GO:0033564	anterior/posterior axon guidance	IEA	biological process
GO:0043005	neuron projection	IEA	cellular component
GO:0045121	membrane raft	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa04360	Axon guidance

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray