• Gene id: 89780

Gene Summary

• Gene Symbol: WNT3A   Gene   UCSC   Ensembl
• Gene name: Wnt family member 3A
• Alternate names: protein Wnt-3a, wingless-type MMTV integration site family, member 3A,
• Gene location: 1q42.13 (126360119: 126494376)     Exons: 19     NC_000005.10
• Gene summary(Entrez): The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryog
• OMIM: 606359

Protein Summary

• Protein general information: P56704  
  • Name: Protein Wnt 3a
  • Length: 352  
  • Mass: 39365
  • Tissue specificity: Moderately expressed in placenta and at low levels in adult lung, spleen, and prostate. {ECO
• Sequence:

  MAPLGYFLLLCSLKQALGSYPIWWSLAVGPQYSSLGSQPILCASIPGLVPKQLRFCRNYVEIMPSVAEGIKIGIQ
  ECQHQFRGRRWNCTTVHDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTAAICGCSSRHQGSPGKGW
  KWGGCSEDIEFGGMVSREFADARENRPDARSAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFR
  AIGDFLKDKYDSASEMVVEKHRESRGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVS
  SHGIDGCDLLCCGRGHNARAERRREKCRCVFHWCCYVSCQECTRVYDVHTCK

• Structural information:
  • Interpro: IPR005817  IPR009141  IPR018161  
  • Prosite: PS00246
  • DIP: 58592
  • STRING: ENSP00000284523
• Other Databases: GeneCards:  WNT3A  Malacards:  WNT3A

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005102	signaling receptor binding	IPI	molecular function
GO:0036465	synaptic vesicle recycling	TAS	biological process
GO:0099054	presynapse assembly	TAS	biological process
GO:0039706	co-receptor binding	IPI	molecular function
GO:1990851	Wnt-Frizzled-LRP5/6 complex	IDA	cellular component
GO:1904953	Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation	TAS	biological process
GO:0045944	positive regulation of transcription by RNA polymerase II	ISS	biological process
GO:0033278	cell proliferation in midbrain	TAS	biological process
GO:0005109	frizzled binding	IBA	molecular function
GO:0030182	neuron differentiation	IBA	biological process
GO:0060070	canonical Wnt signaling pathway	IBA	biological process
GO:0005125	cytokine activity	IBA	molecular function
GO:0005615	extracellular space	IBA	cellular component
GO:0045165	cell fate commitment	IBA	biological process
GO:0005615	extracellular space	IDA	cellular component
GO:0060070	canonical Wnt signaling pathway	IMP	biological process
GO:0008283	cell population proliferation	IMP	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0016055	Wnt signaling pathway	IEA	biological process
GO:0005102	signaling receptor binding	IEA	molecular function
GO:0007275	multicellular organism development	IEA	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0016055	Wnt signaling pathway	IEA	biological process
GO:0007275	multicellular organism development	IEA	biological process
GO:0060070	canonical Wnt signaling pathway	IDA	biological process
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005788	endoplasmic reticulum lumen	TAS	cellular component
GO:0005796	Golgi lumen	TAS	cellular component
GO:0005796	Golgi lumen	TAS	cellular component
GO:0005796	Golgi lumen	TAS	cellular component
GO:0016055	Wnt signaling pathway	TAS	biological process
GO:0030666	endocytic vesicle membrane	TAS	cellular component
GO:0030666	endocytic vesicle membrane	TAS	cellular component
GO:0031901	early endosome membrane	TAS	cellular component
GO:0070062	extracellular exosome	TAS	cellular component
GO:1904886	beta-catenin destruction complex disassembly	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0048018	receptor ligand activity	IDA	molecular function
GO:0060070	canonical Wnt signaling pathway	IDA	biological process
GO:0098978	glutamatergic synapse	IEA	cellular component
GO:0060923	cardiac muscle cell fate commitment	IEA	biological process
GO:0050770	regulation of axonogenesis	IEA	biological process
GO:0050768	negative regulation of neurogenesis	IEA	biological process
GO:0048697	positive regulation of collateral sprouting in absence of injury	IEA	biological process
GO:0048643	positive regulation of skeletal muscle tissue development	IEA	biological process
GO:0048343	paraxial mesodermal cell fate commitment	IEA	biological process
GO:0045893	positive regulation of transcription, DNA-templated	IEA	biological process
GO:0045599	negative regulation of fat cell differentiation	IEA	biological process
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IEA	biological process
GO:0042472	inner ear morphogenesis	IEA	biological process
GO:0036342	post-anal tail morphogenesis	IEA	biological process
GO:0030168	platelet activation	IEA	biological process
GO:0022008	neurogenesis	IEA	biological process
GO:0021904	dorsal/ventral neural tube patterning	IEA	biological process
GO:0021846	cell proliferation in forebrain	IEA	biological process
GO:0021766	hippocampus development	IEA	biological process
GO:0021527	spinal cord association neuron differentiation	IEA	biological process
GO:0016055	Wnt signaling pathway	IEA	biological process
GO:0009952	anterior/posterior pattern specification	IEA	biological process
GO:0008284	positive regulation of cell population proliferation	IEA	biological process
GO:0005615	extracellular space	IEA	cellular component
GO:0001947	heart looping	IEA	biological process
GO:0001819	positive regulation of cytokine production	IEA	biological process
GO:0001649	osteoblast differentiation	IEA	biological process
GO:2001141	regulation of RNA biosynthetic process	IEA	biological process
GO:2000347	positive regulation of hepatocyte proliferation	IEA	biological process
GO:2000179	positive regulation of neural precursor cell proliferation	IEA	biological process
GO:2000081	positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation	IEA	biological process
GO:2000049	positive regulation of cell-cell adhesion mediated by cadherin	IEA	biological process
GO:1901215	negative regulation of neuron death	IEA	biological process
GO:0099527	postsynapse to nucleus signaling pathway	IEA	biological process
GO:0090676	calcium ion transmembrane transport via low voltage-gated calcium channel	IEA	biological process
GO:0090263	positive regulation of canonical Wnt signaling pathway	IEA	biological process
GO:0090245	axis elongation involved in somitogenesis	IEA	biological process
GO:0070527	platelet aggregation	IEA	biological process
GO:0070507	regulation of microtubule cytoskeleton organization	IEA	biological process
GO:0061098	positive regulation of protein tyrosine kinase activity	IEA	biological process
GO:0060070	canonical Wnt signaling pathway	IEA	biological process
GO:0051091	positive regulation of DNA-binding transcription factor activity	IEA	biological process
GO:0050804	modulation of chemical synaptic transmission	IEA	biological process
GO:0048843	negative regulation of axon extension involved in axon guidance	IEA	biological process
GO:0048103	somatic stem cell division	IEA	biological process
GO:0048018	receptor ligand activity	IEA	molecular function
GO:0045944	positive regulation of transcription by RNA polymerase II	IEA	biological process
GO:0045860	positive regulation of protein kinase activity	IEA	biological process
GO:0045595	regulation of cell differentiation	IEA	biological process
GO:0045202	synapse	IEA	cellular component
GO:0035914	skeletal muscle cell differentiation	IEA	biological process
GO:0034613	cellular protein localization	IEA	biological process
GO:0033278	cell proliferation in midbrain	IEA	biological process
GO:0030901	midbrain development	IEA	biological process
GO:0030890	positive regulation of B cell proliferation	IEA	biological process
GO:0030879	mammary gland development	IEA	biological process
GO:0030198	extracellular matrix organization	IEA	biological process
GO:0030097	hemopoiesis	IEA	biological process
GO:0021874	Wnt signaling pathway involved in forebrain neuroblast division	IEA	biological process
GO:0019904	protein domain specific binding	IEA	molecular function
GO:0010977	negative regulation of neuron projection development	IEA	biological process
GO:0010387	COP9 signalosome assembly	IEA	biological process
GO:0009986	cell surface	IEA	cellular component
GO:0007498	mesoderm development	IEA	biological process
GO:0007411	axon guidance	IEA	biological process
GO:0007409	axonogenesis	IEA	biological process
GO:0007368	determination of left/right symmetry	IEA	biological process
GO:0005109	frizzled binding	IEA	molecular function
GO:0003713	transcription coactivator activity	IEA	molecular function
GO:0001934	positive regulation of protein phosphorylation	IEA	biological process
GO:0001756	somitogenesis	IEA	biological process
GO:0001701	in utero embryonic development	IEA	biological process
GO:1904798	positive regulation of core promoter binding	IEA	biological process
GO:1904339	negative regulation of dopaminergic neuron differentiation	IEA	biological process
GO:1903078	positive regulation of protein localization to plasma membrane	IEA	biological process
GO:0048018	receptor ligand activity	IDA	molecular function
GO:0032092	positive regulation of protein binding	IDA	biological process
GO:0061184	positive regulation of dermatome development	IDA	biological process
GO:0061317	canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment	IDA	biological process
GO:2000727	positive regulation of cardiac muscle cell differentiation	IDA	biological process
GO:0010628	positive regulation of gene expression	IDA	biological process
GO:0005615	extracellular space	ISS	cellular component
GO:0008284	positive regulation of cell population proliferation	ISS	biological process
GO:0021846	cell proliferation in forebrain	ISS	biological process
GO:0045893	positive regulation of transcription, DNA-templated	ISS	biological process
GO:0050768	negative regulation of neurogenesis	ISS	biological process
GO:0001934	positive regulation of protein phosphorylation	IDA	biological process
GO:0001934	positive regulation of protein phosphorylation	IDA	biological process
GO:0002092	positive regulation of receptor internalization	IDA	biological process
GO:0003136	negative regulation of heart induction by canonical Wnt signaling pathway	IDA	biological process
GO:0033138	positive regulation of peptidyl-serine phosphorylation	IDA	biological process
GO:0090263	positive regulation of canonical Wnt signaling pathway	IDA	biological process
GO:0090263	positive regulation of canonical Wnt signaling pathway	IDA	biological process
GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	biological process
GO:0048337	positive regulation of mesodermal cell fate specification	IDA	biological process
GO:0060070	canonical Wnt signaling pathway	IDA	biological process
GO:0060070	canonical Wnt signaling pathway	IDA	biological process
GO:0060070	canonical Wnt signaling pathway	IDA	biological process
GO:0009986	cell surface	ISS	cellular component
GO:0010387	COP9 signalosome assembly	ISS	biological process
GO:0062009	secondary palate development	IMP	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0098793	presynapse	IEA	cellular component
GO:0060070	canonical Wnt signaling pathway	IDA	biological process
GO:0010977	negative regulation of neuron projection development	ISS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0071300	cellular response to retinoic acid	ISS	biological process
GO:0030182	neuron differentiation	ISS	biological process
GO:1905606	regulation of presynapse assembly	IMP	biological process
GO:1905606	regulation of presynapse assembly	IDA	biological process
GO:0050807	regulation of synapse organization	IMP	biological process
GO:0050807	regulation of synapse organization	IDA	biological process
GO:0098978	glutamatergic synapse	IMP	cellular component
GO:0098978	glutamatergic synapse	IDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa05200	Pathways in cancer
hsa05010	Alzheimer disease
hsa05165	Human papillomavirus infection
hsa05206	MicroRNAs in cancer
hsa05205	Proteoglycans in cancer
hsa04310	Wnt signaling pathway
hsa04150	mTOR signaling pathway
hsa04390	Hippo signaling pathway
hsa05225	Hepatocellular carcinoma
hsa04934	Cushing syndrome
hsa05226	Gastric cancer
hsa04550	Signaling pathways regulating pluripotency of stem cells
hsa05224	Breast cancer
hsa04916	Melanogenesis
hsa05217	Basal cell carcinoma

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq