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Gene id 894
Gene Summary     SNPs    Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed    

Gene Summary

Gene Symbol CCND2   Gene   UCSC   Ensembl
Aliases KIAK0002, MPPH3
Gene name cyclin D2
Alternate names G1/S-specific cyclin-D2,
Gene location 12p13.32 (4273761: 4305352)     Exons: 5     NC_000001.11
Gene summary(Entrez) The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit
OMIM 123833

SNPs


rs7811653

Strand:    Allele origin:   Allele change:   Mutation type: snv

NC_000007.14   g.46362671C>A
NC_000007.13   g.46402269C>A|SEQ=[C/A]

rs6080550

Strand:    Allele origin:   Allele change:   Mutation type: snv

NC_000020.11   g.1778944C>G
NC_000020.11   g.1778944C>T
NC_000020.10   g.1759590C>G
NC_000020.10   g.1759590C>T|SEQ=[C/G/T]|GENE=LOC100289473

Protein Summary

Gene ontology

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GO accessionTerm nameEvidence codeGo category

KEGG pathways

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Pathway idPathway name
hsa04068FoxO signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04110Cell cycle
hsa04115p53 signaling pathway
hsa04218Cellular senescence
hsa04510Focal adhesion
hsa04917Prolactin signaling pathway
hsa05200Pathways in cancer
hsa05202Transcriptional misregulation in cancer
hsa05206MicroRNAs in cancer
hsa05203Viral carcinogenesis
hsa05166Human T-cell leukemia virus 1 infection
hsa05162Measles
hsa05169Epstein-Barr virus infection
hsa05165Human papillomavirus infection
hsa05200Pathways in cancer
hsa04151PI3K-Akt signaling pathway
hsa05166Human T-cell leukemia virus 1 infection
hsa05203Viral carcinogenesis
hsa05202Transcriptional misregulation in cancer
hsa04218Cellular senescence
hsa05206MicroRNAs in cancer
hsa05165Human papillomavirus infection
hsa04390Hippo signaling pathway
hsa04310Wnt signaling pathway
hsa04510Focal adhesion
hsa04068FoxO signaling pathway
hsa05169Epstein-Barr virus infection
hsa04110Cell cycle
hsa04115p53 signaling pathway
hsa04340Hedgehog signaling pathway
hsa04917Prolactin signaling pathway
hsa05162Measles
hsa04630JAK-STAT signaling pathway
Associated diseases References
Cancer (ovarian) GAD: 19738611
Testicular cancer MIK: H00023
Cancer (breast) GAD: 18507837
Cancer GAD: 20414251
Diabetes GAD: 19252133
Major depressive disorder GAD: 19107115
Spermatogenesis defects MIK: 24667226
Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome KEGG: H01885
Aberrant CpGs in Low Motility Sperm MIK: 21674046
Role in spermatogenesis MIK: 24667226
Teratozoospermia MIK: 17327269
Unexplained infertility MIK: 25753583

PubMed references

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PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
24667226 Role in sp
ermatogene
sis


Male infertility
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17327269 Teratozoos
permia

13 (5 controls,
8 cases)
Male infertility GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
Show abstract
21674046 Aberrant C
pGs in Low
Motility
Sperm

18
Male infertility GSE26881
Show abstract
25753583 Unexplaine
d infertil
ity

46 (17 fertile
men, 29 male pa
tients)
Male infertility Microarray
Show abstract