Gene id |
8870 |
Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed |
Gene Summary
|
Gene Symbol |
IER3 Gene UCSC Ensembl |
Aliases |
DIF-2, DIF2, GLY96, IEX-1, IEX-1L, IEX1, PRG1 |
Gene name |
immediate early response 3 |
Alternate names |
radiation-inducible immediate-early gene IEX-1, PACAP-responsive gene 1 protein, anti-death protein, differentiation-dependent gene 2 protein, expressed in pancreatic carcinoma, gly96, mouse, homolog of, immediate early protein GLY96, immediate early response 3 , |
Gene location |
6p21.33 (30744546: 30743198) Exons: 2 NC_000006.12
|
Gene summary(Entrez) |
This gene functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced apoptosis. Partially degraded and unspliced transcripts are found after virus infection in vitro, but these transcripts are not found in vivo and do not g
|
OMIM |
300926 |
Protein Summary
|
Protein general information
| P46695
Name: Radiation inducible immediate early gene IEX 1 (Differentiation dependent gene 2 protein) (Protein DIF 2) (Immediate early protein GLY96) (Immediate early response 3 protein) (PACAP responsive gene 1 protein) (Protein PRG1)
Length: 156 Mass: 16903
|
Sequence |
MCHSRSCHPTMTILQAPTPAPSTIPGPRRGSGPEIFTFDPLPEPAAAPAGRPSASRGHRKRSRRVLYPRVVRRQL PVEEPNPAKRLLFLLLTIVFCQILMAEEGVPAPLPPEDAPNAASLAPTPVSAVLEPFNLTSEPSDYALDLSTFLQ QHPAAF
|
Structural information |
|
Other Databases |
GeneCards: IER3 Malacards: IER3 |
|
GO accession | Term name | Evidence code | Go category |
---|
GO:2001020 |
regulation of response to DNA damage stimulus
|
IBA |
biological process |
GO:0005634 |
nucleus
|
IBA |
cellular component |
GO:0043066 |
negative regulation of ap optotic process
|
IEA |
biological process |
GO:0016020 |
membrane
|
IEA |
cellular component |
GO:0016021 |
integral component of mem brane
|
IEA |
cellular component |
GO:0006915 |
apoptotic process
|
TAS |
biological process |
GO:0009653 |
anatomical structure morp hogenesis
|
TAS |
biological process |
GO:0043066 |
negative regulation of ap optotic process
|
TAS |
biological process |
GO:0005634 |
nucleus
|
IDA |
cellular component |
GO:2001020 |
regulation of response to DNA damage stimulus
|
IMP |
biological process |
GO:0005829 |
cytosol
|
TAS |
cellular component |
GO:0005829 |
cytosol
|
TAS |
cellular component |
GO:0014066 |
regulation of phosphatidy linositol 3-kinase signal ing
|
TAS |
biological process |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0016020 |
membrane
|
IEA |
cellular component |
|
|
Pathway id | Pathway name |
P06959 | CCKR signaling map | P06959 | CCKR signaling map | P06959 | CCKR signaling map | |
|
Associated diseases |
References |
Aberrant CpGs in Low Motility Sperm | MIK: 21674046 |
Hypospermatogenesis | MIK: 28361989 |
Spermatogenic defects | MIK: 31037746 |
Unexplained infertility | MIK: 25753583 |
|
|
PMID |
Condition |
Mutation |
Ethnicity |
Population details |
Infertility_type |
Associated_genes |
Abstract |
21674046 |
Aberrant C pGs in Low Motility Sperm
|
|
|
18
|
Male infertility |
GSE26881
|
Show abstract |
28361989 |
Hyposperma togenesis
|
|
|
6 (3 controls, 3 Klienfelter s yndrome
|
Male infertility |
Microarray
|
Show abstract |
31037746 |
Spermatoge nic defect s
|
|
|
28 men with az oospermia
|
Male infertility |
Microarray
|
Show abstract |
25753583 |
Unexplaine d infertil ity
|
|
|
46 (17 fertile men, 29 male pa tients)
|
Male infertility |
Microarray
|
Show abstract |
|