• Gene id: 8844

Gene Summary

• Gene Symbol: KSR1   Gene   UCSC   Ensembl
• Aliases: KSR, RSU2
• Gene name: kinase suppressor of ras 1
• Alternate names: kinase suppressor of Ras 1,
• Gene location: 17q11.2 (27456440: 27626437)     Exons: 31     NC_000017.11
• OMIM: 601132

Protein Summary

• Protein general information: Q8IVT5  
  • Name: Kinase suppressor of Ras 1 (EC 2.7.11.1)
  • Length: 923  
  • Mass: 102160
• Sequence:

  MDRAALRAAAMGEKKEGGGGGDAAAAEGGAGAAASRALQQCGQLQKLIDISIGSLRGLRTKCAVSNDLTQQEIRT
  LEAKLVRYICKQRQCKLSVAPGERTPELNSYPRFSDWLYTFNVRPEVVQEIPRDLTLDALLEMNEAKVKETLRRC
  GASGDECGRLQYALTCLRKVTGLGGEHKEDSSWSSLDARRESGSGPSTDTLSAASLPWPPGSSQLGRAGNSAQGP
  RSISVSALPASDSPTPSFSEGLSDTCIPLHASGRLTPRALHSFITPPTTPQLRRHTKLKPPRTPPPPSRKVFQLL
  PSFPTLTRSKSHESQLGNRIDDVSSMRFDLSHGSPQMVRRDIGLSVTHRFSTKSWLSQVCHVCQKSMIFGVKCKH
  CRLKCHNKCTKEAPACRISFLPLTRLRRTESVPSDINNPVDRAAEPHFGTLPKALTKKEHPPAMNHLDSSSNPSS
  TTSSTPSSPAPFPTSSNPSSATTPPNPSPGQRDSRFNFPAAYFIHHRQQFIFPVPSAGHCWKCLLIAESLKENAF
  NISAFAHAAPLPEAADGTRLDDQPKADVLEAHEAEAEEPEAGKSEAEDDEDEVDDLPSSRRPWRGPISRKASQTS
  VYLQEWDIPFEQVELGEPIGQGRWGRVHRGRWHGEVAIRLLEMDGHNQDHLKLFKKEVMNYRQTRHENVVLFMGA
  CMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVFYDNGKVVITD
  FGLFGISGVVREGRRENQLKLSHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVYAFGTVWYELQARDWPLKNQA
  AEASIWQIGSGEGMKRVLTSVSLGKEVSEILSACWAFDLQERPSFSLLMDMLEKLPKLNRRLSHPGHFWKSADIN
  SSKVVPRFERFGLGVLESSNPKM

• Structural information:
  • Protein Domains: (613..88-)
    (/note="Protein-kinase)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"-)
  • Interpro: IPR011009  IPR025561  IPR002219  IPR000719  IPR013761   IPR001245  IPR008271  
  • Prosite: PS50011 PS00108 PS00479 PS50081
  • CDD: cd00029
  • PDB: 5VYK
  • PDBsum: 5VYK
  • DIP: 32619
  • STRING: ENSP00000381958
• Other Databases: GeneCards:  KSR1  Malacards:  KSR1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0007265	Ras protein signal transduction	IBA	biological process
GO:0007165	signal transduction	IBA	biological process
GO:0005783	endoplasmic reticulum	IBA	cellular component
GO:0016020	membrane	IBA	cellular component
GO:0005737	cytoplasm	IBA	cellular component
GO:0004672	protein kinase activity	IBA	molecular function
GO:0005078	MAP-kinase scaffold activity	ISS	molecular function
GO:0019933	cAMP-mediated signaling	ISS	biological process
GO:0007265	Ras protein signal transduction	ISS	biological process
GO:0042127	regulation of cell population proliferation	ISS	biological process
GO:0043410	positive regulation of MAPK cascade	ISS	biological process
GO:0043405	regulation of MAP kinase activity	ISS	biological process
GO:0004672	protein kinase activity	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0006468	protein phosphorylation	IEA	biological process
GO:0035556	intracellular signal transduction	IEA	biological process
GO:0005783	endoplasmic reticulum	IEA	cellular component
GO:0042995	cell projection	IEA	cellular component
GO:0016301	kinase activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0016310	phosphorylation	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0000166	nucleotide binding	IEA	molecular function
GO:0004674	protein serine/threonine kinase activity	IEA	molecular function
GO:0032991	protein-containing complex	IDA	cellular component
GO:0008022	protein C-terminus binding	IDA	molecular function
GO:0005783	endoplasmic reticulum	IDA	cellular component
GO:0016020	membrane	IDA	cellular component
GO:0000165	MAPK cascade	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005078	MAP-kinase scaffold activity	IEA	molecular function
GO:0007265	Ras protein signal transduction	IEA	biological process
GO:0019933	cAMP-mediated signaling	IEA	biological process
GO:0042127	regulation of cell population proliferation	IEA	biological process
GO:0071889	14-3-3 protein binding	IEA	molecular function
GO:0004672	protein kinase activity	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0019901	protein kinase binding	IEA	molecular function
GO:0031434	mitogen-activated protein kinase kinase binding	IEA	molecular function
GO:0043405	regulation of MAP kinase activity	IEA	biological process
GO:0043410	positive regulation of MAPK cascade	IEA	biological process
GO:0051087	chaperone binding	IEA	molecular function
GO:0051879	Hsp90 protein binding	IEA	molecular function
GO:0032587	ruffle membrane	IEA	cellular component
GO:0005789	endoplasmic reticulum membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005524	ATP binding	IDA	molecular function
GO:0000185	activation of MAPKKK activity	IDA	biological process
GO:0071889	14-3-3 protein binding	IDA	molecular function
GO:0016020	membrane	HDA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0007265	Ras protein signal transduction	NAS	biological process

KEGG pathways

Pathway id	Pathway name
hsa04014	Ras signaling pathway
hsa05152	Tuberculosis
hsa04625	C-type lectin receptor signaling pathway

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Hypospermatogenesis	MIK: 28361989
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
28361989	Hypospermatogenesis			6 (3 controls, 3 Klienfelter syndrome	Male infertility	Microarray