• Gene id: 8804

Gene Summary

• Gene Symbol: CREG1   Gene   UCSC   Ensembl
• Aliases: CREG
• Gene name: cellular repressor of E1A stimulated genes 1
• Alternate names: protein CREG1,
• Gene location: 1q24.2 (167553761: 167541012)     Exons: 4     NC_000001.11
• Gene summary(Entrez): The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. The protein encoded by this gene antagonizes transcriptional activation and cellular transformation by E1A. This protein
• OMIM: 618055

Protein Summary

• Protein general information: O75629  
  • Name: Protein CREG1 (Cellular repressor of E1A stimulated genes 1)
  • Length: 220  
  • Mass: 24075
• Sequence:

  MAGLSRGSARALLAALLASTLLALLVSPARGRGGRDHGDWDEASRLPPLPPREDAARVARFVTHVSDWGALATIS
  TLEAVRGRPFADVLSLSDGPPGAGSGVPYFYLSPLQLSVSNLQENPYATLTMTLAQTNFCKKHGFDPQSPLCVHI
  MLSGTVTKVNETEMDIAKHSLFIRHPEMKTWPSSHNWFFAKLNITNIWVLDYFGGPKIVTPEEYYNVTVQ

• Structural information:
  • Interpro: IPR014631  IPR012349  
  • PDB: 1XHN
  • PDBsum: 1XHN
  • STRING: ENSP00000359540
• Other Databases: GeneCards:  CREG1  Malacards:  CREG1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005615	extracellular space	IBA	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:0040008	regulation of growth	IEA	biological process
GO:0003714	transcription corepressor activity	TAS	molecular function
GO:0007275	multicellular organism development	TAS	biological process
GO:0006357	regulation of transcription by RNA polymerase II	TAS	biological process
GO:0043312	neutrophil degranulation	TAS	biological process
GO:0005576	extracellular region	TAS	cellular component
GO:0035578	azurophil granule lumen	TAS	cellular component
GO:0008134	transcription factor binding	IEA	molecular function
GO:0006355	regulation of transcription, DNA-templated	IEA	biological process
GO:0005667	transcription regulator complex	IEA	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:1903507	negative regulation of nucleic acid-templated transcription	IEA	biological process
GO:0005615	extracellular space	IDA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881