|
Gene id |
8756 |
| Gene Summary Diseases PubMed |
Gene Summary
|
|
Gene Symbol |
ADAM7 Gene UCSC Ensembl |
|
Aliases |
ADAM 7, ADAM-7, EAPI, GP-83, GP83 |
|
Gene name |
ADAM metallopeptidase domain 7 |
|
Alternate names |
disintegrin and metalloproteinase domain-containing protein 7, a disintegrin and metalloproteinase domain 7, epididymal apical protein I, epididymis secretory sperm binding protein, sperm maturation-related glycoprotein GP-83, |
|
Gene location |
8p21.2 (24441025: 24509564) Exons: 22 NC_000008.11
|
|
Gene summary(Entrez) |
This gene encodes a member of the ADAMs family of zinc proteases. These transmembrane proteins play roles in multiple processes including cell signaling, adhesion and migration. The encoded protein lacks protease activity and may play roles in protein-pro
|
|
OMIM |
607310 |
|
| Associated diseases |
References |
| Fertility defects | MIK: 26246218 |
| Altered epididymal and sperm integrity | MIK: 26246218 |
| Associated with sperm capacitation | MIK: 20945367 |
| Male factor infertility | MIK: 26246218 |
| Spermatogenic defects | MIK: 20945367 |
| Male infertility | MIK: 26246218 |
| Teratozoospermia | MIK: 17327269 |
|
|
| PMID |
Condition |
Mutation |
Ethnicity |
Population details |
Infertility_type |
Associated_genes |
Abstract |
| 20945367 |
Assocaited
with sper
m capacita
tion
|
|
|
|
Male infertility |
|
Show abstract |
| 26246218 |
Reduced fe
rtility, a
ltered epi
didymal an
d sperm in
tegrity, M
ale infert
ility
|
|
|
|
Male infertility |
|
Show abstract |
| 17327269 |
Teratozoos
permia
|
|
|
13 (5 controls,
8 cases)
|
Male infertility |
GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
|
Show abstract |
|