• Gene id: 8747

Gene Summary

• Gene Symbol: ADAM21   Gene   UCSC   Ensembl
• Aliases: ADAM 21, ADAM31
• Gene name: ADAM metallopeptidase domain 21
• Alternate names: disintegrin and metalloproteinase domain-containing protein 21, ADAM metallopeptidase domain 21, preproprotein, a disintegrin and metalloproteinase domain 21,
• Gene location: 14q24.2 (65982229: 65960683)     Exons: 12     NC_000007.14
• Gene summary(Entrez): This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes
• OMIM: 603713

Protein Summary

• Protein general information: Q9UKJ8  
  • Name: Disintegrin and metalloproteinase domain containing protein 21 (ADAM 21) (EC 3.4.24. )
  • Length: 722  
  • Mass: 80834
• Sequence:

  MAVDGTLVYIRVTLLLLWLGVFLSISGYCQAGPSQHFTSPEVVIPLKVISRGRSAKAPGWLSYSLRFGGQKHVVH
  MRVKKLLVSRHLPVFTYTDDRALLEDQLFIPDDCYYHGYVEAAPESLVVFSACFGGFRGVLKISGLTYEIEPIRH
  SATFEHLVYKINSNETQFPAMRCGLTEKEVARQQLEFEEAENSALEPKSAGDWWTHAWFLELVVVVNHDFFIYSQ
  SNISKVQEDVFLVVNIVDSMYKQLGTYIILIGIEIWNQGNVFPMTSIEQVLNDFSQWKQISLSQLQHDAAHMFIK
  NSLISILGLAYVAGICRPPIDCGVDNFQGDTWSLFANTVAHELGHTLGMQHDEEFCFCGERGCIMNTFRVPAEKF
  TNCSYADFMKTTLNQGSCLHNPPRLGEIFMLKRCGNGVVEREEQCDCGSVQQCEQDACCLLNCTLRPGAACAFGL
  CCKDCKFMPSGELCRQEVNECDLPEWCNGTSHQCPEDRYVQDGIPCSDSAYCYQKRCNNHDQHCREIFGKDAKSA
  SQNCYKEINSQGNRFGHCGINGTTYLKCHISDVFCGRVQCENVRDIPLLQDHFTLQHTHINGVTCWGIDYHLRMN
  ISDIGEVKDGTVCGPGKICIHKKCVSLSVLSHVCLPETCNMKGICNNKHHCHCGYGWSPPYCQHRGYGGSIDSGP
  ASAKRGVFLPLIVIPSLSVLTFLFTVGLLMYLRQCSGPKETKAHSSG

• Structural information:
  • Protein Domains: (208..39-)
    (/note="Peptidase-M12B)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00276-)
    (406..49-)
    (/note="Disintegrin-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00068-)
    (634..66-)
    (/note="EGF-like"-)
  • Interpro: IPR006586  IPR018358  IPR001762  IPR036436  IPR013032   IPR024079  IPR001590  IPR002870  IPR034027  
  • Prosite: PS50215 PS00427 PS50214 PS01186 PS00142
  • CDD: cd04269
  • STRING: ENSP00000474385
• Other Databases: GeneCards:  ADAM21  Malacards:  ADAM21

Gene ontology

GO accession	Term name	Evidence code	Go category

Diseases

Associated diseases	References
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
31037746	Spermatogenic defects			28 men with azoospermia	Male infertility	Microarray