• Gene id: 8743

Gene Summary

• Gene Symbol: TNFSF10   Gene   UCSC   Ensembl
• Aliases: APO2L, Apo-2L, CD253, TL2, TNLG6A, TRAIL
• Gene name: TNF superfamily member 10
• Alternate names: tumor necrosis factor ligand superfamily member 10, Apo-2 ligand, TNF-related apoptosis inducing ligand TRAIL, chemokine tumor necrosis factor ligand superfamily member 10, tumor necrosis factor (ligand) family, member 10, tumor necrosis factor (ligand) s,
• Gene location: 3q26.31 (172523506: 172505507)     Exons: 6     NC_000003.12
• Gene summary(Entrez): The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed a
• OMIM: 603598

Protein Summary

• Protein general information: P50591  
  • Name: Tumor necrosis factor ligand superfamily member 10 (Apo 2 ligand) (Apo 2L) (TNF related apoptosis inducing ligand) (Protein TRAIL) (CD antigen CD253)
  • Length: 281  
  • Mass: 32,509
  • Tissue specificity: Testis-specific. Drastically down-regulated in testis from patients with Sertoli cell-only syndrome (SCOS). {ECO
• Sequence:

  MAMMEVQGGPSLGQTCVLIVIFTVLLQSLCVAVTYVYFTNELKQMQDKYSKSGIACFLKEDDSYWDPNDEESMNS
  PCWQVKWQLRQLVRKMILRTSEETISTVQEKQQNISPLVRERGPQRVAAHITGTRGRSNTLSSPNSKNEKALGRK
  INSWESSRSGHSFLSNLHLRNGELVIHEKGFYYIYSQTYFRFQEEIKENTKNDKQMVQYIYKYTSYPDPILLMKS
  ARNSCWSKDAEYGLYSIYQGGIFELKENDRIFVSVTNEHLIDMDHEASFFGAFLVG

• Structural information:
  • Interpro: IPR021184  IPR006052  IPR017355  IPR008983  
  • Prosite: PS00251 PS50049
  • PDB: 1D0G 1D2Q 1D4V 1DG6 1DU3 4N90 5CIR
  • PDBsum: 1D0G 1D2Q 1D4V 1DG6 1DU3 4N90 5CIR
  • DIP: 6230
  • STRING: ENSP00000241261
• Other Databases: GeneCards:  TNFSF10  Malacards:  TNFSF10

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005102	receptor binding	TAS	molecular function
GO:0005102	receptor binding	TAS	molecular function
GO:0005125	cytokine activity	IEA	molecular function
GO:0005164	tumor necrosis factor receptor binding	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005615	extracellular space	IEA	cellular component
GO:0005887	integral component of plasma membrane	TAS	cellular component
GO:0006915	apoptotic process	TAS	biological process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	TAS	biological process
GO:0006955	immune response	IEA	biological process
GO:0007165	signal transduction	TAS	biological process
GO:0007165	signal transduction	TAS	biological process
GO:0007166	cell surface receptor signaling pathway	TAS	biological process
GO:0007267	cell-cell signaling	TAS	biological process
GO:0043065	positive regulation of apoptotic process	IDA	biological process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IEP	biological process
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA	biological process
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA	biological process
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0070062	extracellular exosome	IDA	cellular component
GO:0090200	positive regulation of release of cytochrome c from mitochondria	IDA	biological process
GO:0097296	activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	TAS	biological process
GO:1902041	regulation of extrinsic apoptotic signaling pathway via death domain receptors	TAS	biological process
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	TAS	biological process
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	TAS	biological process
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	IDA	biological process
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	IDA	biological process
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	IDA	biological process
GO:0005102	receptor binding	TAS	molecular function
GO:0005102	receptor binding	TAS	molecular function
GO:0005125	cytokine activity	IEA	molecular function
GO:0005164	tumor necrosis factor receptor binding	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005615	extracellular space	IEA	cellular component
GO:0005887	integral component of plasma membrane	TAS	cellular component
GO:0006915	apoptotic process	IEA	biological process
GO:0006915	apoptotic process	TAS	biological process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	TAS	biological process
GO:0006955	immune response	IEA	biological process
GO:0007165	signal transduction	TAS	biological process
GO:0007165	signal transduction	TAS	biological process
GO:0007166	cell surface receptor signaling pathway	TAS	biological process
GO:0007267	cell-cell signaling	TAS	biological process
GO:0016020	membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0032813	tumor necrosis factor receptor superfamily binding	IEA	molecular function
GO:0043065	positive regulation of apoptotic process	IDA	biological process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IEP	biological process
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA	biological process
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA	biological process
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0070062	extracellular exosome	IDA	cellular component
GO:0090200	positive regulation of release of cytochrome c from mitochondria	IDA	biological process
GO:0097296	activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	TAS	biological process
GO:1902041	regulation of extrinsic apoptotic signaling pathway via death domain receptors	TAS	biological process
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	TAS	biological process
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	TAS	biological process
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	IEA	biological process
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	IDA	biological process
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	IDA	biological process
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	IDA	biological process
GO:0005102	receptor binding	TAS	molecular function
GO:0005102	receptor binding	TAS	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005887	integral component of plasma membrane	TAS	cellular component
GO:0006915	apoptotic process	TAS	biological process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	TAS	biological process
GO:0007165	signal transduction	TAS	biological process
GO:0007165	signal transduction	TAS	biological process
GO:0007166	cell surface receptor signaling pathway	TAS	biological process
GO:0007267	cell-cell signaling	TAS	biological process
GO:0043065	positive regulation of apoptotic process	IDA	biological process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IEP	biological process
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA	biological process
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA	biological process
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA	biological process
GO:0070062	extracellular exosome	IDA	cellular component
GO:0090200	positive regulation of release of cytochrome c from mitochondria	IDA	biological process
GO:0097296	activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	TAS	biological process
GO:1902041	regulation of extrinsic apoptotic signaling pathway via death domain receptors	TAS	biological process
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	TAS	biological process
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	TAS	biological process
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	IDA	biological process
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	IDA	biological process
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	IDA	biological process

KEGG pathways

Pathway id	Pathway name
hsa04068	FoxO signaling pathway
hsa04060	Cytokine-cytokine receptor interaction
hsa04061	Viral protein interaction with cytokine and cytokine receptor
hsa04210	Apoptosis
hsa04217	Necroptosis
hsa04650	Natural killer cell mediated cytotoxicity
hsa05130	Pathogenic Escherichia coli infection
hsa05164	Influenza A

Diseases

Associated diseases	References
Cancer (head and neck)	GAD: 20819778
Cancer (myeloma)	GAD: 20568250
Cancer (ovarian)	GAD: 20628624
Chronic lymphocytic leukemia	GAD: 19573080
Cancer (breast)	GAD: 19890662
Multiple sclerosis	GAD: 16040132
Systemic lupus erythematosus (SLE)	GAD: 18174230
Bone diseases	GAD: 19453261
Chronic renal failure	GAD: 21085059
Endometriosis	INFBASE: 15242994
Varicocele	MIK: 25351208
Male factor infertility	MIK: 21317160
Spermatogenesis defects	MIK: 24825910
Male Infertility	MIK: 21317160
Varicocele	MIK: 25351208
Spermatogenic defects	MIK: 24736722
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
24825910	Spermatozoa survival			123 male donors presenting for infertility evaluation	Male infertility
21317160	Male subfertility			33 (22 subfertile men, 11 fertile men)	Male subfertility	DFF40 Casp4 Casp 6 and TNFSF10
25351208	Male infertility, varicocele		Egyptia n	112 (30 fertile males with varicocele, 44 infertile males with varicocele and 38 healthy fertile control subjects without varicocele)	Male infertility
24736722	Role in spermatogenesis				Male infertility
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)