• Gene id: 8741

Gene Summary

• Gene Symbol: TNFSF13   Gene   UCSC   Ensembl
• Aliases: APRIL, CD256, TALL-2, TALL2, TNLG7B, TRDL-1, UNQ383/PRO715, ZTNF2
• Gene name: TNF superfamily member 13
• Alternate names: tumor necrosis factor ligand superfamily member 13, TNF- and APOL-related leukocyte expressed ligand 2, a proliferation-inducing ligand, tumor necrosis factor (ligand) superfamily, member 13, tumor necrosis factor ligand 7B, tumor necrosis factor superfamily m,
• Gene location: 17p13.1 (7558291: 7561607)     Exons: 6     NC_000017.11
• Gene summary(Entrez): The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell develop
• OMIM: 603621

Protein Summary

• Protein general information: O75888  
  • Name: Tumor necrosis factor ligand superfamily member 13 (A proliferation inducing ligand) (APRIL) (TNF and APOL related leukocyte expressed ligand 2) (TALL 2) (TNF related death ligand 1) (TRDL 1) (CD antigen CD256)
  • Length: 250  
  • Mass: 27433
  • Tissue specificity: Expressed at high levels in transformed cell lines, cancers of colon, thyroid, lymphoid tissues and specifically expressed in monocytes and macrophages.
• Sequence:

  MPASSPFLLAPKGPPGNMGGPVREPALSVALWLSWGAALGAVACAMALLTQQTELQSLRREVSRLQGTGGPSQNG
  EGYPWQSLPEQSSDALEAWENGERSRKRRAVLTQKQKKQHSVLHLVPINATSKDDSDVTEVMWQPALRRGRGLQA
  QGYGVRIQDAGVYLLYSQVLFQDVTFTMGQVVSREGQGRQETLFRCIRSMPSHPDRAYNSCYSAGVFHLHQGDIL
  SVIIPRARAKLNLSPHGTFLGFVKL

• Structural information:
  • Interpro: IPR021184  IPR006052  IPR008983  
  • Prosite: PS00251 PS50049
  • CDD: cd00184
  • PDB: 4ZCH
  • PDBsum: 4ZCH
  • DIP: 6232
  • STRING: ENSP00000343505
• Other Databases: GeneCards:  TNFSF13  Malacards:  TNFSF13

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005615	extracellular space	IBA	cellular component
GO:0048298	positive regulation of isotype switching to IgA isotypes	IBA	biological process
GO:0005102	signaling receptor binding	IBA	molecular function
GO:0005886	plasma membrane	IBA	cellular component
GO:0005164	tumor necrosis factor receptor binding	IEA	molecular function
GO:0006955	immune response	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0002376	immune system process	IEA	biological process
GO:0005615	extracellular space	IEA	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:0005125	cytokine activity	IEA	molecular function
GO:0005102	signaling receptor binding	TAS	molecular function
GO:0007165	signal transduction	TAS	biological process
GO:0008284	positive regulation of cell population proliferation	TAS	biological process
GO:0048298	positive regulation of isotype switching to IgA isotypes	IDA	biological process
GO:0005576	extracellular region	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0033209	tumor necrosis factor-mediated signaling pathway	TAS	biological process
GO:0043488	regulation of mRNA stability	TAS	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa04060	Cytokine-cytokine receptor interaction
hsa05323	Rheumatoid arthritis
hsa04672	Intestinal immune network for IgA production

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq