• Gene id: 8731

Gene Summary

• Gene Symbol: RNMT   Gene   UCSC   Ensembl
• Aliases: CMT1, CMT1c, MET, Met, RG7MT1, cm1p, hCMT1, hMet
• Gene name: RNA guanine-7 methyltransferase
• Alternate names: mRNA cap guanine-N7 methyltransferase, RNA (guanine-7-) methyltransferase, hcm1p, mRNA (guanine-7-)methyltransferase, mRNA (guanine-N(7)-)-methyltransferase, mRNA cap methyltransferase,
• Gene location: 18p11.21 (13726644: 13764555)     Exons: 15     NC_000018.10
• OMIM: 603514

Protein Summary

• Protein general information: O43148  
  • Name: mRNA cap guanine N7 methyltransferase (EC 2.1.1.56) (RG7MT1) (mRNA (guanine N(7) ) methyltransferase) (mRNA cap methyltransferase) (hCMT1) (hMet) (hcm1p)
  • Length: 476  
  • Mass: 54844
  • Tissue specificity: Widely expressed. {ECO
• Sequence:

  MANSAKAEEYEKMSLEQAKASVNSETESSFNINENTTASGTGLSEKTSVCRQVDIARKRKEFEDDLVKESSSCGK
  DTPSKKRKLDPEIVPEEKDCGDAEGNSKKRKRETEDVPKDKSSTGDGTQNKRKIALEDVPEKQKNLEEGHSSTVA
  AHYNELQEVGLEKRSQSRIFYLRNFNNWMKSVLIGEFLEKVRQKKKRDITVLDLGCGKGGDLLKWKKGRINKLVC
  TDIADVSVKQCQQRYEDMKNRRDSEYIFSAEFITADSSKELLIDKFRDPQMCFDICSCQFVCHYSFESYEQADMM
  LRNACERLSPGGYFIGTTPNSFELIRRLEASETESFGNEIYTVKFQKKGDYPLFGCKYDFNLEGVVDVPEFLVYF
  PLLNEMAKKYNMKLVYKKTFLEFYEEKIKNNENKMLLKRMQALEPYPANESSKLVSEKVDDYEHAAKYMKNSQVR
  LPLGTLSKSEWEATSIYLVFAFEKQQ

• Structural information:
  • Protein Domains: (128..47-)
    0 (/note="mRNA-cap)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00895"-)
  • Interpro: IPR004971  IPR016899  IPR039753  IPR029063  
  • Prosite: PS51562
  • PDB: 3BGV 3EPP 5E8J 5E9J 5E9W
  • PDBsum: 3BGV 3EPP 5E8J 5E9J 5E9W
  • STRING: ENSP00000372804
• Other Databases: GeneCards:  RNMT  Malacards:  RNMT

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004482	mRNA (guanine-N7-)-methyltransferase activity	IBA	molecular function
GO:0005634	nucleus	IBA	cellular component
GO:0005845	mRNA cap binding complex	IBA	cellular component
GO:0006370	7-methylguanosine mRNA capping	IBA	biological process
GO:0031533	mRNA cap methyltransferase complex	IDA	cellular component
GO:0006370	7-methylguanosine mRNA capping	IDA	biological process
GO:0004482	mRNA (guanine-N7-)-methyltransferase activity	IDA	molecular function
GO:0005845	mRNA cap binding complex	IDA	cellular component
GO:0004482	mRNA (guanine-N7-)-methyltransferase activity	IDA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0006370	7-methylguanosine mRNA capping	IEA	biological process
GO:0042025	host cell nucleus	IEA	cellular component
GO:0004482	mRNA (guanine-N7-)-methyltransferase activity	IEA	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0006370	7-methylguanosine mRNA capping	IEA	biological process
GO:0032259	methylation	IEA	biological process
GO:0006397	mRNA processing	IEA	biological process
GO:0003723	RNA binding	IEA	molecular function
GO:0008168	methyltransferase activity	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0003723	RNA binding	TAS	molecular function
GO:0004482	mRNA (guanine-N7-)-methyltransferase activity	TAS	molecular function
GO:0006370	7-methylguanosine mRNA capping	TAS	biological process
GO:0005634	nucleus	TAS	cellular component
GO:0004482	mRNA (guanine-N7-)-methyltransferase activity	IEA	molecular function
GO:0043235	receptor complex	IDA	cellular component
GO:0004482	mRNA (guanine-N7-)-methyltransferase activity	TAS	molecular function
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0006366	transcription by RNA polymerase II	TAS	biological process
GO:0006370	7-methylguanosine mRNA capping	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:1990830	cellular response to leukemia inhibitory factor	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0001650	fibrillar center	IDA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0106005	RNA 5'-cap (guanine-N7)-methylation	IEA	biological process
GO:0106005	RNA 5'-cap (guanine-N7)-methylation	IEA	biological process
GO:0106005	RNA 5'-cap (guanine-N7)-methylation	IEA	biological process
GO:0106005	RNA 5'-cap (guanine-N7)-methylation	IEA	biological process
GO:0106005	RNA 5'-cap (guanine-N7)-methylation	IEA	biological process
GO:0106005	RNA 5'-cap (guanine-N7)-methylation	IEA	biological process
GO:0106005	RNA 5'-cap (guanine-N7)-methylation	IEA	biological process
GO:0106005	RNA 5'-cap (guanine-N7)-methylation	IEA	biological process
GO:0005634	nucleus	IDA	cellular component
GO:0004482	mRNA (guanine-N7-)-methyltransferase activity	IMP	molecular function
GO:0003723	RNA binding	IMP	molecular function
GO:0006370	7-methylguanosine mRNA capping	IMP	biological process

KEGG pathways

Pathway id	Pathway name
hsa03015	mRNA surveillance pathway

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)