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Gene id 8697
Gene Summary    Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed    

Gene Summary
Gene Symbol CDC23   Gene   UCSC   Ensembl
Aliases ANAPC8, APC8, CUT23
Gene name cell division cycle 23
Alternate names cell division cycle protein 23 homolog, anaphase-promoting complex subunit 8, cell division cycle 23 homolog, cyclosome subunit 8,
Gene location 5q31.2 (138213322: 138187649)     Exons: 16     NC_000005.10
Gene summary(Entrez) The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed o
OMIM 603462

Protein Summary
Protein general information Q9UJX2  

Name: Cell division cycle protein 23 homolog (Anaphase promoting complex subunit 8) (APC8) (Cyclosome subunit 8)

Length: 597  Mass: 68834

Sequence MAASTSMVPVAVTAAVAPVLSINSDFSDLREIKKQLLLIAGLTRERGLLHSSKWSAELAFSLPALPLAELQPPPP
ITEEDAQDMDAYTLAKAYFDVKEYDRAAHFLHGCNSKKAYFLYMYSRYLSGEKKKDDETVDSLGPLEKGQVKNEA
LRELRVELSKKHQARELDGFGLYLYGVVLRKLDLVKEAIDVFVEATHVLPLHWGAWLELCNLITDKEMLKFLSLP
DTWMKEFFLAHIYTELQLIEEALQKYQNLIDVGFSKSSYIVSQIAVAYHNIRDIDKALSIFNELRKQDPYRIENM
DTFSNLLYVRSMKSELSYLAHNLCEIDKYRVETCCVIGNYYSLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEY
MEMKNTSAAIQAYRHAIEVNKRDYRAWYGLGQTYEILKMPFYCLYYYRRAHQLRPNDSRMLVALGECYEKLNQLV
EAKKCYWRAYAVGDVEKMALVKLAKLHEQLTESEQAAQCYIKYIQDIYSCGEIVEHLEESTAFRYLAQYYFKCKL
WDEASTCAQKCCAFNDTREEGKALLRQILQLRNQGETPTTEVPAPFFLPASLSANNTPTRRVSPLNLSSVTP
Structural information
Interpro:  IPR007192  IPR013026  IPR011990  IPR019734  
Prosite:   PS50005 PS50293

PDB:  		 4UI9 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H
PDBsum:   4UI9 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H

DIP:  
32959
MINT:  
STRING:   ENSP00000378350
Other Databases GeneCards:  CDC23  Malacards:  CDC23

Gene ontology

Expand All | Collapse All
GO accessionTerm nameEvidence codeGo category
GO:0005737 cytoplasm
 IBA cellular component
GO:0007091 metaphase/anaphase transi
tion of mitotic cell cycl
e
 IBA biological process
GO:0016567 protein ubiquitination
 IBA biological process
GO:0031145 anaphase-promoting comple
x-dependent catabolic pro
cess
 IBA biological process
GO:0005680 anaphase-promoting comple
x
 IBA cellular component
GO:0045842 positive regulation of mi
totic metaphase/anaphase
transition
 IBA biological process
GO:0051301 cell division
 IBA biological process
GO:0070979 protein K11-linked ubiqui
tination
 IDA biological process
GO:0005680 anaphase-promoting comple
x
 IDA cellular component
GO:0005680 anaphase-promoting comple
x
 IDA cellular component
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005680 anaphase-promoting comple
x
 IEA cellular component
GO:0030071 regulation of mitotic met
aphase/anaphase transitio
n
 IEA biological process
GO:0051301 cell division
 IEA biological process
GO:0007049 cell cycle
 IEA biological process
GO:0007091 metaphase/anaphase transi
tion of mitotic cell cycl
e
 TAS biological process
GO:0005680 anaphase-promoting comple
x
 TAS cellular component
GO:0006511 ubiquitin-dependent prote
in catabolic process
 TAS biological process
GO:0000278 mitotic cell cycle
 TAS biological process
GO:0007096 regulation of exit from m
itosis
 TAS biological process
GO:0031145 anaphase-promoting comple
x-dependent catabolic pro
cess
 TAS biological process
GO:0031145 anaphase-promoting comple
x-dependent catabolic pro
cess
 TAS biological process
GO:0031145 anaphase-promoting comple
x-dependent catabolic pro
cess
 TAS biological process
GO:0031145 anaphase-promoting comple
x-dependent catabolic pro
cess
 TAS biological process
GO:0031145 anaphase-promoting comple
x-dependent catabolic pro
cess
 TAS biological process
GO:0005654 nucleoplasm
 TAS cellular component
GO:0005654 nucleoplasm
 TAS cellular component
GO:0005654 nucleoplasm
 TAS cellular component
GO:0005654 nucleoplasm
 TAS cellular component
GO:0005654 nucleoplasm
 TAS cellular component
GO:0005654 nucleoplasm
 TAS cellular component
GO:0005654 nucleoplasm
 TAS cellular component
GO:0005654 nucleoplasm
 TAS cellular component
GO:0005654 nucleoplasm
 TAS cellular component
GO:0005654 nucleoplasm
 TAS cellular component
GO:0005654 nucleoplasm
 TAS cellular component
GO:0005829 cytosol
 TAS cellular component
GO:0005829 cytosol
 TAS cellular component
GO:0005829 cytosol
 TAS cellular component
GO:0005829 cytosol
 TAS cellular component
GO:0005829 cytosol
 TAS cellular component
GO:0005829 cytosol
 TAS cellular component
GO:0005829 cytosol
 TAS cellular component
GO:0005829 cytosol
 TAS cellular component
GO:0005829 cytosol
 TAS cellular component
GO:0005829 cytosol
 TAS cellular component
GO:0005829 cytosol
 TAS cellular component
GO:0005829 cytosol
 TAS cellular component
GO:0005829 cytosol
 TAS cellular component
GO:0005829 cytosol
 TAS cellular component
GO:0005829 cytosol
 TAS cellular component
GO:0005829 cytosol
 TAS cellular component
GO:0005829 cytosol
 TAS cellular component
GO:0005829 cytosol
 TAS cellular component
GO:0005829 cytosol
 TAS cellular component
GO:0005829 cytosol
 TAS cellular component
GO:0005829 cytosol
 TAS cellular component
GO:0006511 ubiquitin-dependent prote
in catabolic process
 TAS biological process
GO:0006511 ubiquitin-dependent prote
in catabolic process
 TAS biological process
GO:0006511 ubiquitin-dependent prote
in catabolic process
 TAS biological process
GO:0006511 ubiquitin-dependent prote
in catabolic process
 TAS biological process
GO:0006511 ubiquitin-dependent prote
in catabolic process
 TAS biological process
GO:1901990 regulation of mitotic cel
l cycle phase transition
 TAS biological process
GO:0005622 intracellular
 IDA cellular component
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0016567 protein ubiquitination
 IEA biological process
GO:0007080 mitotic metaphase plate c
ongression
 IDA biological process
GO:0000278 mitotic cell cycle
 IDA biological process
GO:0030071 regulation of mitotic met
aphase/anaphase transitio
n
 IDA biological process
GO:0005680 anaphase-promoting comple
x
 IDA cellular component
GO:0004842 ubiquitin-protein transfe
rase activity
 TAS molecular function

KEGG pathways

Expand All | Collapse All

Pathway idPathway name
hsa05166Human T-cell leukemia virus 1 infection
hsa04120Ubiquitin mediated proteolysis
hsa04110Cell cycle
hsa04114Oocyte meiosis
hsa04914Progesterone-mediated oocyte maturation

Diseases

Expand All | Collapse All
Associated diseases References
Aberrant CpGs in Low Motility Sperm MIK: 21674046
Teratozoospermia MIK: 17327269

PubMed references

Expand All | Collapse All
PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
17327269 Teratozoos
permia
13 (5 controls,
8 cases)
 Male infertility GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
 Show abstract
17327269 Teratozoos
permia
19 (6 controls
, 13 cases)
 Male infertility GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
 Show abstract
21674046 Aberrant C
pGs in Low
Motility
Sperm
18
 Male infertility GSE26881
 Show abstract