• Gene id: 8683

Gene Summary

• Gene Symbol: SRSF9   Gene   UCSC   Ensembl
• Aliases: SFRS9, SRp30c
• Gene name: serine and arginine rich splicing factor 9
• Alternate names: serine/arginine-rich splicing factor 9, SR splicing factor 9, pre-mRNA-splicing factor SRp30C, splicing factor, arginine/serine-rich 9,
• Gene location: 12q24.31 (120469754: 120461667)     Exons: 4     NC_000012.12
• Gene summary(Entrez): The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for
• OMIM: 601943

Protein Summary

• Protein general information: Q13242  
  • Name: Serine/arginine rich splicing factor 9 (Pre mRNA splicing factor SRp30C) (Splicing factor, arginine/serine rich 9)
  • Length: 221  
  • Mass: 25,542
• Sequence:

  MSGWADERGGEGDGRIYVGNLPTDVREKDLEDLFYKYGRIREIELKNRHGLVPFAFVRFEDPRDAEDAIYGRNGY
  DYGQCRLRVEFPRTYGGRGGWPRGGRNGPPTRRSDFRVLVSGLPPSGSWQDLKDHMREAGDVCYADVQKDGVGMV
  EYLRKEDMEYALRKLDDTKFRSHEGETSYIRVYPERSTSYGYSRSRSGSRGRDSPYQSRGSPHYFSPFRPY

• Structural information:
  • Protein Domains: RRM (14-89)
    RRM (111-187)
  • Interpro: IPR012677  IPR035979  IPR000504  IPR034503  IPR034995  
  • Prosite: PS50102
  • CDD: cd12598 cd12768
  • DIP: 40741
  • STRING: ENSP00000229390
• Other Databases: GeneCards:  SRSF9  Malacards:  SRSF9

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0000166	nucleotide binding	IEA	molecular function
GO:0000398	mRNA splicing, via spliceosome	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005730	nucleolus	IDA	cellular component
GO:0006369	termination of RNA polymerase II transcription	TAS	biological process
GO:0006376	mRNA splice site selection	TAS	biological process
GO:0006397	mRNA processing	TAS	biological process
GO:0006405	RNA export from nucleus	TAS	biological process
GO:0006406	mRNA export from nucleus	TAS	biological process
GO:0031124	mRNA 3'-end processing	TAS	biological process
GO:0044822	poly(A) RNA binding	IDA	molecular function
GO:0044822	poly(A) RNA binding	IDA	molecular function
GO:0048025	negative regulation of mRNA splicing, via spliceosome	IDA	biological process
GO:0000166	nucleotide binding	IEA	molecular function
GO:0000398	mRNA splicing, via spliceosome	TAS	biological process
GO:0003676	nucleic acid binding	IEA	molecular function
GO:0003723	RNA binding	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005730	nucleolus	IDA	cellular component
GO:0006369	termination of RNA polymerase II transcription	TAS	biological process
GO:0006376	mRNA splice site selection	TAS	biological process
GO:0006397	mRNA processing	IEA	biological process
GO:0006397	mRNA processing	TAS	biological process
GO:0006405	RNA export from nucleus	TAS	biological process
GO:0006406	mRNA export from nucleus	TAS	biological process
GO:0008380	RNA splicing	IEA	biological process
GO:0031124	mRNA 3'-end processing	TAS	biological process
GO:0044822	poly(A) RNA binding	IDA	molecular function
GO:0044822	poly(A) RNA binding	IDA	molecular function
GO:0048025	negative regulation of mRNA splicing, via spliceosome	IDA	biological process
GO:0000398	mRNA splicing, via spliceosome	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005730	nucleolus	IDA	cellular component
GO:0006369	termination of RNA polymerase II transcription	TAS	biological process
GO:0006376	mRNA splice site selection	TAS	biological process
GO:0006397	mRNA processing	TAS	biological process
GO:0006405	RNA export from nucleus	TAS	biological process
GO:0006406	mRNA export from nucleus	TAS	biological process
GO:0031124	mRNA 3'-end processing	TAS	biological process
GO:0044822	poly(A) RNA binding	IDA	molecular function
GO:0044822	poly(A) RNA binding	IDA	molecular function
GO:0048025	negative regulation of mRNA splicing, via spliceosome	IDA	biological process

KEGG pathways

Pathway id	Pathway name
hsa05168	Herpes simplex virus 1 infection

Diseases

Associated diseases	References
Cancer (glaucoma)	GAD: 20376328
Non obstructive azoospermia	MIK: 24661730
Nonobstructive azoospermia (NOA)	MIK: 24661730

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
24661730	Nonobstructive azoospermia (NOA)	SFRS9 (rs17431717, rs10849753), SFRS6 (rs6103330), SFRS4 (rs12046213)		2893 (962 Nonobstructive azoospermia (NOA), 1,931 control subjects)	Male infertility	SFRS4 SFRS6 SFRS9