• Gene id: 8673

Gene Summary

• Gene Symbol: VAMP8   Gene   UCSC   Ensembl
• Aliases: EDB, VAMP-8
• Gene name: vesicle associated membrane protein 8
• Alternate names: vesicle-associated membrane protein 8, vesicle-associated membrane protein 8 (endobrevin),
• Gene location: 2p11.2 (69359704: 69427076)     Exons: 11     NC_000012.12
• Gene summary(Entrez): This gene encodes an integral membrane protein that belongs to the synaptobrevin/vesicle-associated membrane protein subfamily of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs). The encoded protein is involved in the fusio
• OMIM: 603177

Protein Summary

• Protein general information: Q9BV40  
  • Name: Vesicle associated membrane protein 8 (VAMP 8) (Endobrevin) (EDB)
  • Length: 100  
  • Mass: 11438
  • Tissue specificity: Platelets. {ECO
• Sequence:

  MEEASEGGGNDRVRNLQSEVEGVKNIMTQNVERILARGENLEHLRNKTEDLEATSEHFKTTSQKVARKFWWKNVK
  MIVLICVIVFIIILFIVLFATGAFS

• Structural information:
  • Protein Domains: (12..7-)
    homology (/note="v-SNARE-coiled-coil)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00290"-)
  • Interpro: IPR001388  IPR016444  IPR042855  
  • Prosite: PS00417 PS50892
  • PDB: 4WY4
  • PDBsum: 4WY4
  • DIP: 40358
  • STRING: ENSP00000263864
• Other Databases: GeneCards:  VAMP8  Malacards:  VAMP8

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0098594	mucin granule	IBA	cellular component
GO:0070254	mucus secretion	IBA	biological process
GO:0031201	SNARE complex	IBA	cellular component
GO:0006906	vesicle fusion	IBA	biological process
GO:0035493	SNARE complex assembly	IBA	biological process
GO:0019905	syntaxin binding	IBA	molecular function
GO:0005886	plasma membrane	IBA	cellular component
GO:0005484	SNAP receptor activity	IBA	molecular function
GO:0031902	late endosome membrane	IDA	cellular component
GO:0031201	SNARE complex	IDA	cellular component
GO:0005765	lysosomal membrane	IDA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0097352	autophagosome maturation	IMP	biological process
GO:0016192	vesicle-mediated transport	IEA	biological process
GO:0016021	integral component of membrane	IEA	cellular component
GO:0005768	endosome	IEA	cellular component
GO:0005764	lysosome	IEA	cellular component
GO:0015031	protein transport	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0006914	autophagy	IEA	biological process
GO:0005886	plasma membrane	IEA	cellular component
GO:0005769	early endosome	TAS	cellular component
GO:0016020	membrane	TAS	cellular component
GO:0031201	SNARE complex	IDA	cellular component
GO:0046718	viral entry into host cell	IMP	biological process
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0006892	post-Golgi vesicle-mediated transport	TAS	biological process
GO:0030667	secretory granule membrane	TAS	cellular component
GO:0030670	phagocytic vesicle membrane	TAS	cellular component
GO:0035577	azurophil granule membrane	TAS	cellular component
GO:0035579	specific granule membrane	TAS	cellular component
GO:0043312	neutrophil degranulation	TAS	biological process
GO:0070821	tertiary granule membrane	TAS	cellular component
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	TAS	biological process
GO:0030665	clathrin-coated vesicle membrane	TAS	cellular component
GO:0030665	clathrin-coated vesicle membrane	TAS	cellular component
GO:0030665	clathrin-coated vesicle membrane	TAS	cellular component
GO:0030665	clathrin-coated vesicle membrane	TAS	cellular component
GO:0030665	clathrin-coated vesicle membrane	TAS	cellular component
GO:0030665	clathrin-coated vesicle membrane	TAS	cellular component
GO:0030665	clathrin-coated vesicle membrane	TAS	cellular component
GO:0055038	recycling endosome membrane	TAS	cellular component
GO:0061024	membrane organization	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005765	lysosomal membrane	IEA	cellular component
GO:0031901	early endosome membrane	IEA	cellular component
GO:0031902	late endosome membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0016240	autophagosome membrane docking	IDA	biological process
GO:0005829	cytosol	IDA	cellular component
GO:0055037	recycling endosome	IDA	cellular component
GO:0048471	perinuclear region of cytoplasm	IDA	cellular component
GO:0031201	SNARE complex	IDA	cellular component
GO:1903531	negative regulation of secretion by cell	IDA	biological process
GO:0035577	azurophil granule membrane	IDA	cellular component
GO:0005886	plasma membrane	IDA	cellular component
GO:0098594	mucin granule	IDA	cellular component
GO:0031201	SNARE complex	IDA	cellular component
GO:0016020	membrane	IDA	cellular component
GO:0030667	secretory granule membrane	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0031982	vesicle	IDA	cellular component
GO:1903076	regulation of protein localization to plasma membrane	IDA	biological process
GO:0019869	chloride channel inhibitor activity	IDA	molecular function
GO:0043312	neutrophil degranulation	IMP	NOT|biological process
GO:1903595	positive regulation of histamine secretion by mast cell	IMP	biological process
GO:0043308	eosinophil degranulation	IMP	NOT|biological process
GO:0070062	extracellular exosome	HDA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component
GO:0070254	mucus secretion	IMP	biological process

KEGG pathways

Pathway id	Pathway name
hsa04140	Autophagy - animal
hsa04611	Platelet activation
hsa04130	SNARE interactions in vesicular transport

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881