• Gene id: 8669

Gene Summary

• Gene Symbol: EIF3J   Gene   UCSC   Ensembl
• Aliases: EIF3S1, eIF3-alpha, eIF3-p35
• Gene name: eukaryotic translation initiation factor 3 subunit J
• Alternate names: eukaryotic translation initiation factor 3 subunit J, eukaryotic translation initiation factor 3, subunit 1 (alpha, 35kD),
• Gene location: 15q21.1 (35342557: 35428190)     Exons: 13     NC_000006.12
• Gene summary(Entrez): This gene encodes a core subunit of the eukaryotic initiation factor 3 complex, which participates in the initiation of translation by aiding in the recruitment of protein and mRNA components to the 40S ribosome. There are pseudogenes for this gene on chr
• OMIM: 603910

Protein Summary

• Protein general information: O75822  
  • Name: Eukaryotic translation initiation factor 3 subunit J (eIF3j) (Eukaryotic translation initiation factor 3 subunit 1) (eIF 3 alpha) (eIF3 p35)
  • Length: 258  
  • Mass: 29062
• Sequence:

  MAAAAAAAGDSDSWDADAFSVEDPVRKVGGGGTAGGDRWEGEDEDEDVKDNWDDDDDEKKEEAEVKPEVKISEKK
  KIAEKIKEKERQQKKRQEEIKKRLEEPEEPKVLTPEEQLADKLRLKKLQEESDLELAKETFGVNNAVYGIDAMNP
  SSRDDFTEFGKLLKDKITQYEKSLYYASFLEVLVRDVCISLEIDDLKKITNSLTVLCSEKQKQEKQSKAKKKKKG
  VVPGGGLKATMKDDLADYGGYDGGYVQDYEDFM

• Structural information:
  • Interpro: IPR023194  IPR013906  
  • PDB: 2KRB 3BPJ
  • PDBsum: 2KRB 3BPJ
  • DIP: 31117
  • STRING: ENSP00000261868
• Other Databases: GeneCards:  EIF3J  Malacards:  EIF3J

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005852	eukaryotic translation initiation factor 3 complex	IBA	cellular component
GO:0003743	translation initiation factor activity	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005852	eukaryotic translation initiation factor 3 complex	IEA	cellular component
GO:0003743	translation initiation factor activity	IEA	molecular function
GO:0006412	translation	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0006413	translational initiation	IEA	biological process
GO:0006413	translational initiation	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0042802	identical protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0016282	eukaryotic 43S preinitiation complex	IEA	cellular component
GO:0002183	cytoplasmic translational initiation	IEA	biological process
GO:0003743	translation initiation factor activity	IEA	molecular function
GO:0033290	eukaryotic 48S preinitiation complex	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0001732	formation of cytoplasmic translation initiation complex	IEA	biological process
GO:0005852	eukaryotic translation initiation factor 3 complex	IEA	cellular component
GO:0003743	translation initiation factor activity	IC	contributes to
GO:0005852	eukaryotic translation initiation factor 3 complex	IDA	cellular component
GO:0003743	translation initiation factor activity	IC	contributes to
GO:0006413	translational initiation	IC	biological process
GO:0006413	translational initiation	IC	biological process
GO:0005852	eukaryotic translation initiation factor 3 complex	IDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa03013	RNA transport

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881