• Gene id: 8668

Gene Summary

• Gene Symbol: EIF3I   Gene   UCSC   Ensembl
• Aliases: EIF3S2, PRO2242, TRIP-1, TRIP1, eIF3-beta, eIF3-p36
• Gene name: eukaryotic translation initiation factor 3 subunit I
• Alternate names: eukaryotic translation initiation factor 3 subunit I, TGF-beta receptor-interacting protein 1, TGFbeta receptor-interacting protein 1, eukaryotic translation initiation factor 3 subunit 2, eukaryotic translation initiation factor 3, subunit 2 (beta, 36kD), euk,
• Gene location: 1p35.2 (32221583: 32231603)     Exons: 12     NC_000001.11
• OMIM: 609715

Protein Summary

• Protein general information: Q13347  
  • Name: Eukaryotic translation initiation factor 3 subunit I (eIF3i) (Eukaryotic translation initiation factor 3 subunit 2) (TGF beta receptor interacting protein 1) (TRIP 1) (eIF 3 beta) (eIF3 p36)
  • Length: 325  
  • Mass: 36502
• Sequence:

  MKPILLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKHVLTGSADNS
  CRLWDCETGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQCFVSFFDLRDPSQIDNNEPYMKIPCNDSKIT
  SAVWGPLGECIIAGHESGELNQYSAKSGEVLVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTTLEHQKT
  FRTERPVNSAALSPNYDHVVLGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSY
  SSGGEDGYVRIHYFDPQYFEFEFEA

• Structural information:
  • Interpro: IPR027525  IPR015943  IPR001680  IPR019775  IPR017986   IPR036322  
  • Prosite: PS00678 PS50082 PS50294
  • DIP: 31116
  • STRING: ENSP00000362688
• Other Databases: GeneCards:  EIF3I  Malacards:  EIF3I

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0003743	translation initiation factor activity	IBA	molecular function
GO:0002183	cytoplasmic translational initiation	IBA	biological process
GO:0071541	eukaryotic translation initiation factor 3 complex, eIF3m	IBA	cellular component
GO:0003723	RNA binding	IBA	molecular function
GO:0003743	translation initiation factor activity	IDA	contributes to
GO:0005852	eukaryotic translation initiation factor 3 complex	IDA	cellular component
GO:0003743	translation initiation factor activity	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005852	eukaryotic translation initiation factor 3 complex	IEA	cellular component
GO:0003743	translation initiation factor activity	IEA	molecular function
GO:0006412	translation	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0006413	translational initiation	IEA	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0006413	translational initiation	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0003743	translation initiation factor activity	IEA	molecular function
GO:0005852	eukaryotic translation initiation factor 3 complex	IEA	cellular component
GO:0006413	translational initiation	IEA	biological process
GO:0071541	eukaryotic translation initiation factor 3 complex, eIF3m	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0016282	eukaryotic 43S preinitiation complex	IEA	cellular component
GO:0033290	eukaryotic 48S preinitiation complex	IEA	cellular component
GO:0003743	translation initiation factor activity	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0002183	cytoplasmic translational initiation	IEA	biological process
GO:0005852	eukaryotic translation initiation factor 3 complex	IEA	cellular component
GO:0001732	formation of cytoplasmic translation initiation complex	IEA	biological process
GO:0003743	translation initiation factor activity	IC	contributes to
GO:0006413	translational initiation	IC	biological process
GO:0005852	eukaryotic translation initiation factor 3 complex	IDA	cellular component
GO:0005852	eukaryotic translation initiation factor 3 complex	IDA	cellular component
GO:0005852	eukaryotic translation initiation factor 3 complex	IDA	cellular component
GO:0003743	translation initiation factor activity	IDA	molecular function
GO:0003743	translation initiation factor activity	IC	contributes to
GO:0006413	translational initiation	IDA	biological process
GO:0006413	translational initiation	IC	biological process
GO:0070062	extracellular exosome	HDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa03013	RNA transport

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881